Results 261 to 270 of about 1,306,054 (295)

Drugs and addiction: an introduction to epigenetics

Addiction, 2011
ABSTRACTAddiction is a debilitating psychiatric disorder, with a complex aetiology involving the interaction of inherited predispositions and environmental factors. Emerging evidence suggests that epigenetic alterations to the genome, including DNA methylation and histone modifications, are important mechanisms underlying addiction and the ...
Wong, Chloe C. Y., Mill, Jonathan, Fernandes, Cathy   +2 more
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Epigenetic Drugs in the Treatment of Endometriosis

Reproductive Sciences, 2019
We read with great interest the study by Seo et al1 entitled “Trichostatin A induces NAG-1 expression and apoptosis in human endometriotic stromal cells” published in your journal. The authors investigated the use of trichostatin A (TPA), a histone deacetylase inhibitor (HDACI), for inducing growth arrest and apoptosis of human endometriotic stromal ...
Barra, Fabio, Ferrero, Simone
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Epigenetic Drugs for Mood Disorders

2018
There is increasing evidence that changes in epigenetic mechanisms of gene expression are involved in the pathogenesis of mood disorders. Such evidence stems from studies conducted on postmortem brain tissues and peripheral cells or tissues of patients with mood disorders.
Jacob, Peedicayil, Aniket, Kumar
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Epigenetic Drugs: A Longstanding Story

Seminars in Oncology, 2005
In this chapter, the development of decitabine from its synthesis in 1964 to the submission of a registration file in 2004 is reviewed. The proper application of the unique properties of decitabine took quite some time to elucidate. In addition, the practical handling in the clinic was not easy as the prolonged myelosuppression of decitabine made it ...
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Epigenetic Drugs in Cognitive Disorders

Current Pharmaceutical Design, 2014
Cognitive disorders are an important group of disorders affecting the brain for which currently used drugs are often of low efficacy and mainly of symptomatic value. There is increasing evidence suggesting that epigenetic changes in gene expression underlie cognitive disorders. Advances in epigenetics have given rise to a new class of drugs, epigenetic
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Preclinical epigenetic models for screening epigenetic drugs for schizophrenia

Journal of Pharmacological and Toxicological Methods, 2016
Schizophrenia is an important psychiatric disorder for which effective drugs are available. However, there are problems with current drug therapy of schizophrenia in that some patients do not respond adequately. Moreover, some patients show treatment resistance and some patients show cognitive decline despite treatment.
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Cancer epigenetics and the potential of epigenetic drugs for treating solid tumors

Expert Review of Anticancer Therapy, 2018
Introduction: Epigenetic modification without DNA sequence mutation plays an important role in cancer development. Some small molecular inhibitors targeting key epigenetic molecules have been approved by the Food and Drug Administration to treat hematological malignancies.
Zhenghui Liu, Yingxue Gao, Xiong Li
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Epigenetic Drug Discovery

Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company, and a substantial number of biotechnology companies, targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia.
M V N L Chaitanya, Trudi Collet, Jon Adams, Kamal Dua, Sachin Kumar Singh   +4 more
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Cancer epigenetics in clinical practice

Ca-A Cancer Journal for Clinicians, 2023
Veronica Davalos, Manel Esteller
exaly  

Novel Approaches to Epigenetic Therapies: From Drug Combinations to Epigenetic Editing

Genes, 2021
Aleksandra Majchrzak-Celińska
exaly