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Epigenetics for Drug Discovery
2015Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company and a substantial number of biotechnology companies targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia.
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Targeting epigenetic regulators to overcome drug resistance in cancers
Signal Transduction and Targeted Therapy, 2023Bin Yu
exaly
2015
The molecular aetiology of disease relies on a complex interplay between our underlying genetic predispositions and the more dynamic epigenetic signatures that govern how our DNA is transcribed. Whilst there is no opportunity to alter the genome with which we are born, there may be potential to understand, modulate and reset aberrant epigenetic motifs ...
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The molecular aetiology of disease relies on a complex interplay between our underlying genetic predispositions and the more dynamic epigenetic signatures that govern how our DNA is transcribed. Whilst there is no opportunity to alter the genome with which we are born, there may be potential to understand, modulate and reset aberrant epigenetic motifs ...
openaire +1 more source
Epigenetic enzyme mutations as mediators of anti-cancer drug resistance
Drug Resistance Updates, 2022Yehuda G Assaraf +2 more
exaly
Tackling drug resistance in ovarian cancer with epigenetic targeted drugs
European Journal of Pharmacology, 2022Qiaojun He, Ling Ding, Hongjie Guo
exaly
The Epigenetics of Autoimmunity and Epigenetic Drug Discovery
2018David F. Tough +3 more
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Combining epigenetic drugs with other therapies for solid tumours — past lessons and future promise
Nature Reviews Clinical Oncology, 2019Sophie Postel-Vinay +2 more
exaly