The role of m6A epigenetic modifications in tumor coding and non-coding RNA processing
Cell Communication and Signaling, 2023 Background Epigenetic modifications of RNA significantly contribute to the regulatory processes in tumors and have, thus, received considerable attention.
Tongxuan Wen +5 more
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Epigenetic Regulation in the Pathogenesis of Rheumatoid Arthritis
Frontiers in Immunology, 2022 Rheumatoid arthritis (RA) is an autoimmune disease. The etiology of RA remains undetermined and the pathogenesis is complex. There remains a paucity of ideal therapeutic drugs and treatment strategies. The epigenetic modifications affect and regulate the
Chao Yang +8 more
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Epigenetic modifications affect Dnmt3L expression [PDF]
Biochemical Journal, 2004 Imprinted genes are expressed from a single allele due to differential methylation of maternal or paternal alleles during gametogenesis. Dnmt3L (DNA cytosine-5-methyltransferase 3 like), a member of de novo methyltransferase Dnmt3 protein family, is a regulator of maternal imprinting.
Ulla, Aapola +3 more
openaire +2 more sources
Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
core +9 more sources
Roles and therapeutic implications of m6A modification in cancer immunotherapy
Frontiers in Immunology, 2023 Recent studies have demonstrated that N6-methyladenosine (m6A), the most abundant, dynamic, and reversible epigenetic RNA modification in eukaryotes, is regulated by a series of enzymes, including methyltransferases (writers), demethylases (erasers), and
Juan Pan +7 more
doaj +1 more source
Connections between Metabolism and Epigenetic Modification in MDSCs
International Journal of Molecular Sciences, 2020 Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells in the tumor microenvironment (TME). During the differentiation and development of MDSCs from myeloid progenitor cells, their functions are also affected by a series of regulatory
Haiyan Dai +3 more
semanticscholar +1 more source
Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series) [PDF]
, 2014 Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action.
Handy, Diane E., Loscalzo, Joseph
core +1 more source
Epigenetic modification and therapeutic targets of diabetes mellitus
Bioscience Reports, 2020 The prevalence of diabetes and its related complications are increasing significantly globally. Collected evidence suggested that several genetic and environmental factors contribute to diabetes mellitus.
Rajveer Singh +6 more
semanticscholar +1 more source
Role of enhancer of zeste homolog 2 polycomb protein and its significance in tumor progression and cell differentiation [PDF]
, 2013 Epigenetics is a branch of genetics that focuses on the heritable changes of DNA or associated proteins, other than DNA sequence variations, which carry information content during cell division [1,2].
Bagella, Luigi Marco, Marchesi, Irene
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Epigenetic Modulation on Tau Phosphorylation in Alzheimer’s Disease
Neural Plasticity, 2019 Tau hyperphosphorylation is a typical pathological change in Alzheimer’s disease (AD) and is involved in the early onset and progression of AD. Epigenetic modification refers to heritable alterations in gene expression that are not caused by direct ...
Chao-Chao Yu +5 more
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