Results 91 to 100 of about 93,647 (322)

Cell-type-specific resolution epigenetics without the need for cell sorting or single-cell biology. [PDF]

, 2019
High costs and technical limitations of cell sorting and single-cell techniques currently restrict the collection of large-scale, cell-type-specific DNA methylation data.
Barcellos, Lisa F, Criswell, Lindsey A, Eskin, Eleazar, Halperin, Eran, Rahmani, Elior, Rhead, Brooke, Rosset, Saharon, Sankararaman, Sriram, Schweiger, Regev   +8 more
core  

Spermidine Reproduces the Anti‐Inflammatory Effects of Intermittent Fasting and Prevents Urate and Calcium Pyrophosphate Crystal‐Induced Inflammation

Arthritis &Rheumatology, EarlyView.
Objective Gout caused by the formation of monosodium urate (MSU) crystals and calcium pyrophosphate (CPP) deposition disease are two major types of microcrystalline pathologies in adults. They are responsible for recurrent flares that rely on interleukin (IL) 1β via activation of the NLRP3 inflammasome.
Chinh Nghia Pham, Florence Castelli, Flora Finet, Charles Leroy, Céline Chollet, Twinu W. Chirayath, Subhalaxmi Moitra, Mylène Zarka, Agnès Ostertag, François Brial, Christèle Combes, Augustin Latourte, Thomas Bardin, François Fenaille, Pascal Richette, Hang Korng Ea   +15 more
wiley   +1 more source

Integrative mapping of the dog epigenome: Reference annotation for comparative intertissue and cross-species studies [PDF]

, 2023
Keun Hong Son, Mark Borris D. Aldonza, A-Reum Nam, Kang-Hoon Lee, Jeong-Woon Lee, Kyung-Ju Shin, Keunsoo Kang, Je‐Yoel Cho   +7 more
openalex   +1 more source

Mechanisms of Resistance to Cancer Immunotherapy: A Host–Tumor Interaction Perspective; A Review Article

Cancer Nexus, EarlyView.
Mechanisms of resistance to cancer immunotherapy from a host–tumor interaction perspective. The central tumor cell is protected by multiple resistance mechanisms, including genetic mutations, epigenetic modifications, and metabolic alterations. The immunosuppressive tumor microenvironment features myeloid‐derived suppressor cells (MDSCs), regulatory T ...
Mohammed Elmujtba Adam Essa, Hamid Noori, Abdelkareem A. Ahmed   +2 more
wiley   +1 more source

Identifying epigenetic aging moderators using the epigenetic pacemaker

Frontiers in Bioinformatics
Epigenetic clocks are DNA methylation-based chronological age prediction models that are commonly employed to study age-related biology. The difference between the predicted and observed age is often interpreted as a form of biological age acceleration ...
Colin Farrell, Chanyue Hu, Kalsuda Lapborisuth, Kyle Pu, Sagi Snir, Matteo Pellegrini   +5 more
doaj   +1 more source

Stochastic models of nucleosome dynamics reveal regulatory rules of stimulus-induced epigenome remodeling [PDF]

, 2022
Jinsu Kim, Katherine M. Sheu, Quen J. Cheng, Alexander Hoffmann, Germán Enciso   +4 more
openalex   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

The Epigenomics of Pituitary Adenoma

Frontiers in Endocrinology, 2019
Background: The vast majority of pituitary tumors are benign and behave accordingly; however, a fraction are invasive and are more aggressive, with a very small fraction being frankly malignant.
Blake M. Hauser, Ashley Lau, Saksham Gupta, Wenya Linda Bi, Ian F. Dunn   +4 more
doaj   +1 more source

Review of: "Improving disease resistance in plants by editing the epigenome" [PDF]

, 2022
Camilo Useche López
openalex   +1 more source

The bacterial epigenome

Nature Reviews Microbiology, 2019
In all domains of life, genomes contain epigenetic information superimposed over the nucleotide sequence. Epigenetic signals control DNA-protein interactions and can cause phenotypic change in the absence of mutation. A nearly universal mechanism of epigenetic signalling is DNA methylation.
María A. Sánchez-Romero, Josep Casadesús   +1 more
openaire   +3 more sources