Results 91 to 100 of about 21,621 (295)
Genome Biology, 2020 The human epigenome has been experimentally characterized by thousands of measurements for every basepair in the human genome. We propose a deep neural network tensor factorization method, Avocado, that compresses this epigenomic data into a dense ...
semanticscholar +1 more source
Scientific Reports, 2021 Epigenome editing methods enable the precise manipulation of epigenetic modifications, such as histone posttranscriptional modifications (PTMs), for uncovering their biological functions.
Weiye Zhao +6 more
semanticscholar +1 more source
Cancer Communications, EarlyView.Abstract Background Gastric cancer peritoneal metastasis is clinically challenging, given the limited treatment options and poor prognosis. The molecular mechanisms that precede gastric cancer peritoneal metastasis, known as the pre‐metastatic niche (PMN), and its relationship with N6‐methyladenosine (m6A) modification remain unclear.
Song Li +23 more
wiley +1 more source
Frontiers in Oncology, 2012 Human papillomavirus (HPV) infection is well established as etiological agent responsible for a number of pathologies affecting the stratified epithelia of skin and anogenital sites.
Efterpi eKostareli +4 more
doaj +1 more source
Highly Sensitive, Low‐Cost Deep‐UV Resonant Raman Microspectroscopy Systems
Chemistry–Methods, EarlyView.Low‐cost deep UV resonant Raman microscope for chemical sensing and imaging has been developed and its performance has been experimentally validated for several potential applications. Multimodal imaging capabilities of a new instrument have been demonstrated as well.
Joseph Harrington +5 more
wiley +1 more source
Machine Learning for Integrating Data in Biology and Medicine: Principles, Practice, and Opportunities [PDF]
Information Fusion 50 (2019) 71-91, 2018 New technologies have enabled the investigation of biology and human health at an unprecedented scale and in multiple dimensions. These dimensions include a myriad of properties describing genome, epigenome, transcriptome, microbiome, phenotype, and lifestyle.
arxiv +1 more source
WashU Epigenome Browser update 2019
Nucleic Acids Res., 2019 The WashU Epigenome Browser (https://epigenomegateway.wustl.edu/) provides visualization, integration and analysis tools for epigenomic datasets. Since 2010, it has provided the scientific community with data from large consortia including the Roadmap ...
Daofeng Li +4 more
semanticscholar +1 more source
Environmental and Molecular Mutagenesis, EarlyView.Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk +4 more
wiley +1 more source
Mitotic chromatin marking governs the segregation of DNA damage
Nature CommunicationsThe faithful segregation of intact genetic material and the perpetuation of chromatin states through mitotic cell divisions are pivotal for maintaining cell function and identity across cell generations.
Juliette Ferrand +7 more
doaj +1 more source
Epigenome dysregulation in cholangiocarcinoma [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018 Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. Clinically, among solid tumors, the field is still limited. In cholangiocarcinoma (CCA) it is well known that the epigenetic landscape is deregulated both during carcinogenesis and disease progression as
O'Rourke, Colm J +3 more
openaire +4 more sources