Results 1 to 10 of about 195,613 (192)

Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells. [PDF]

PLoS ONE, 2012
Renal tubular epithelial cells of proximal and distal origin differ markedly in their physiological functions. Therefore, we hypothesized that they also differ in their capacity to undergo epithelial to mesenchymal alterations.We used cultures of freshly
Christof Keller, Sven Kroening, Jonathan Zuehlke, Frank Kunath, Bettina Krueger, Margarete Goppelt-Struebe   +5 more
doaj   +5 more sources

Cadherin Expression and EMT: A Focus on Gliomas

Biomedicines, 2021
Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination.
Carolina Noronha, Ana Sofia Ribeiro, Ricardo Taipa, Diogo S. Castro, Joaquim Reis, Cláudia Faria, Joana Paredes   +6 more
doaj   +1 more source

A Novel Role of E-Cadherin-Based Adherens Junctions in Neoplastic Cell Dissemination. [PDF]

PLoS ONE, 2015
Using confocal microscopy, we analyzed the behavior of IAR-6-1, IAR1170, and IAR1162 transformed epithelial cells seeded onto the confluent monolayer of normal IAR-2 epithelial cells.
Svetlana N Rubtsova, Irina Y Zhitnyak, Natalya A Gloushankova   +2 more
doaj   +1 more source

P-Cadherin Regulates Intestinal Epithelial Cell Migration and Mucosal Repair, but Is Dispensable for Colitis Associated Colon Cancer

Cells, 2022
Recurrent chronic mucosal inflammation, a characteristic of inflammatory bowel diseases (IBD), perturbs the intestinal epithelial homeostasis resulting in formation of mucosal wounds and, in most severe cases, leads to colitis-associated colon cancer ...
Nayden G. Naydenov, Susana Lechuga, Ajay Zalavadia, Pranab K. Mukherjee, Ilyssa O. Gordon, David Skvasik, Petra Vidovic, Emina Huang, Florian Rieder, Andrei I. Ivanov   +9 more
doaj   +1 more source

Alpha-1 antitrypsin limits neutrophil extracellular trap disruption of airway epithelial barrier function

Frontiers in Immunology, 2023
Neutrophil extracellular traps contribute to lung injury in cystic fibrosis and asthma, but the mechanisms are poorly understood. We sought to understand the impact of human NETs on barrier function in primary human bronchial epithelial and a human ...
K. M. Hudock, K. M. Hudock, K. M. Hudock, M. S. Collins, M. A. Imbrogno, E. L. Kramer, E. L. Kramer, J. J. Brewington, J. J. Brewington, A. Ziady, A. Ziady, N. Zhang, N. Zhang, J. Snowball, Y. Xu, Y. Xu, Y. Xu, B. C. Carey, B. C. Carey, Y. Horio, Y. Horio, S. M. O’Grady, S. M. O’Grady, E. J. Kopras, J. Meeker, H. Morgan, A. J. Ostmann, E. Skala, M. E. Siefert, C. L. Na, C. R. Davidson, K. Gollomp, K. Gollomp, N. Mangalmurti, N. Mangalmurti, B. C. Trapnell, B. C. Trapnell, B. C. Trapnell, J. P. Clancy   +38 more
doaj   +1 more source

Loss of N-Cadherin Expression in Tumor Transplants Produced From As+3- and Cd+2-Transformed Human Urothelial (UROtsa) Cell Lines. [PDF]

PLoS ONE, 2016
BACKGROUND:Epithelial to mesenchymal transition is a process in which a cell experiences a loss of epithelial cell characteristics and acquires a more mesenchymal cell phenotype.
Elizabeth J Sandquist, Seema Somji, Jane R Dunlevy, Scott H Garrett, Xu Dong Zhou, Andrea Slusser-Nore, Donald A Sens   +6 more
doaj   +1 more source

Induction of the epithelial-mesenchymal transition in the endometrium by chronic endometritis in infertile patients.

PLoS ONE, 2021
BackgroundThe purpose of the present study was to evaluate the relationship between chronic endometritis and the epithelial-mesenchymal transition in the endometrium of infertile patients in the implantation phase.MethodsEndometrial biopsy specimens from
Mitsuaki Ishida, Akie Takebayashi, Fuminori Kimura, Akiko Nakamura, Jun Kitazawa, Aina Morimune, Tetsuro Hanada, Koji Tsuta, Takashi Murakami   +8 more
doaj   +1 more source

E-cadherin on epithelial–mesenchymal transition in thyroid cancer [PDF]

Cancer Cell International, 2021
AbstractThyroid carcinoma is a common malignant tumor of endocrine system and head and neck. Recurrence, metastasis and high malignant expression after routine treatment are serious clinical problems, so it is of great significance to explore its mechanism and find action targets.
Xiaoyu Zhu, Xiaoping Wang, Yifei Gong, Junlin Deng   +3 more
openaire   +3 more sources

CDH1 (cadherin 1, type 1, E-cadherin (epithelial)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on CDH1 (cadherin 1, type 1, E-cadherin (epithelial)), with data on DNA, on the protein encoded, and where the gene is implicated.
MF Calmon, P Rahal
openaire   +1 more source

Misregulated E-cadherin expression associated with an aggressive brain tumor phenotype. [PDF]

PLoS ONE, 2010
Cadherins are essential components of the adherens junction complexes that mediate cell-cell adhesion and regulate cell motility. During tissue morphogenesis, changes in cadherin expression (known as cadherin switching) are a common mechanism for ...
Laura J Lewis-Tuffin, Fausto Rodriguez, Caterina Giannini, Bernd Scheithauer, Brian M Necela, Jann N Sarkaria, Panos Z Anastasiadis   +6 more
doaj   +1 more source