Results 11 to 20 of about 195,613 (192)

Vangl2 Regulates E-Cadherin in Epithelial Cells [PDF]

Scientific Reports, 2014
E-cadherin belongs to the classic cadherin subfamily of calcium-dependent cell adhesion molecules and is crucial for the formation and function of epithelial adherens junctions. In this study, we demonstrate that Vangl2, a vertebrate regulator of planar cell polarity (PCP), controls E-cadherin in epithelial cells.
Nagaoka, Tadahiro, Inutsuka, Ayumu, Begum, Khadiza, hafiz, Khandakar musabbir bin, Kishi, Masashi   +4 more
openaire   +2 more sources

Induction of entosis by epithelial cadherin expression [PDF]

Cell Research, 2014
Cell engulfment typically targets dead or dying cells for clearance from metazoan tissues. However, recent evidence demonstrates that live cells can also be targeted and that engulfment can cause cell death. Entosis is one mechanism proposed to mediate the engulfment and killing of live tumor cells by their neighbors, an activity often referred to as ...
Qiang, Sun, Edmund S, Cibas, Hongyan, Huang, Louis, Hodgson, Michael, Overholtzer   +4 more
openaire   +2 more sources

Cadherins in the retinal pigment epithelium (RPE) revisited: P-cadherin is the highly dominant cadherin expressed in human and mouse RPE in vivo. [PDF]

PLoS ONE, 2018
The retinal pigment epithelium (RPE) supports the health and function of retinal photoreceptors and is essential for normal vision. RPE cells are post-mitotic, terminally differentiated, and polarized epithelial cells. In pathological conditions, however,
Xue Yang, Jin-Yong Chung, Usha Rai, Noriko Esumi   +3 more
doaj   +1 more source

Role of E-Cadherin in Epithelial Architecture Maintenance [PDF]

Cell Communication & Adhesion, 2010
Morphogenesis and architecture of a developing epithelium is controlled by both cell shape and contacts, mediated by spatially and temporally regulated cell adhesion molecules. The authors study if E-cadherin functions as a key factor of epithelial adhesion and epidermal architecture in vivo.
Izaguirre, María Fernanda, Larrea, D., Adur, Javier Fernando, Diaz Zamboni, Javier Eduardo, Vicente, N. B., Galetto, Carolina, Casco, Victor Hugo   +6 more
openaire   +3 more sources

Soluble E‐cadherin: A marker of genital epithelial disruption

American Journal of Reproductive Immunology, 2022
AbstractProblemThe genital epithelial barrier is a crucial first line of defence against HIV, and epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial integrity requires biopsies, but their collection is not practical in many research settings.
Rachel Liu, Eric Armstrong, Shirley Constable, Lane B Buchanan, Avid Mohammadi, Ronald M Galiwango, Sanja Huibner, Marie C Perry, Jessica L Prodger, Bryan Coburn, Rupert Kaul   +10 more
openaire   +2 more sources

Cadherin-23 mediates heterotypic cell-cell adhesion between breast cancer epithelial cells and fibroblasts. [PDF]

PLoS ONE, 2012
In the early stages of breast cancer metastasis, epithelial cells penetrate the basement membrane and invade the surrounding stroma, where they encounter fibroblasts.
Maria Apostolopoulou, Lee Ligon
doaj   +1 more source

E‐cadherin: From epithelial glue to immunological regulator [PDF]

European Journal of Immunology, 2013
E‐cadherin is best known as a central molecule in adherens junctions, joining adjacent epithelial cells together, thereby safeguarding epithelial barrier function. However, recent findings have uncovered an immunological role for this adhesion molecule, linked to its expression in dendritic cells (DCs) and alternatively activated macrophages (MPHs) and
Van Den Bossche, Jan, Van Ginderachter, Jo   +1 more
openaire   +4 more sources

Enhanced RhoA signaling stabilizes E-cadherin in migrating epithelial monolayers [PDF]

Journal of Cell Science, 2021
AbstractEpithelia migrate as physically coherent populations of cells. Earlier studies revealed that mechanical stress accumulates in these cellular layers as they move. These stresses are characteristically tensile in nature and have often been inferred to arise when moving cells pull upon the cell-cell adhesions that hold them together. We now report
Shafali Gupta, Kinga Duszyc, Suzie Verma, Srikanth Budnar, Xuan Liang, Guillermo A. Gomez, Philippe Marcq, Ivar Noordstra, Alpha S. Yap   +8 more
openaire   +3 more sources

CD44 upregulation in E-cadherin-negative esophageal cancers results in cell invasion. [PDF]

PLoS ONE, 2011
E-cadherin is frequently lost during epithelial-mesenchymal transition and the progression of epithelial tumorigenesis. We found a marker of epithelial-mesenchymal transition, CD44, upregulated in response to functional loss of E-cadherin in esophageal ...
Grégoire F Le Bras, Gillian L Allison, Nicole F Richards, Shazia S Ansari, M Kay Washington, Claudia D Andl   +5 more
doaj   +1 more source

Gastrulation EMT Is Independent of P-Cadherin Downregulation. [PDF]

PLoS ONE, 2016
Epithelial-mesenchymal transition (EMT) is an evolutionarily conserved process during which cells lose epithelial characteristics and gain a migratory phenotype.
Pricila K Moly, James R Cooley, Sebastian L Zeltzer, Tatiana A Yatskievych, Parker B Antin   +4 more
doaj   +1 more source