Results 11 to 20 of about 472,049 (341)
Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]
, 1997 Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew +2 more
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BioTechniques, 2008 Epitope tagging is widely used in the characterization of newly discovered proteins. This review presents an overview of how the technique evolved and how it is being used today, with a focus on its use in the study of protein-protein interactions. In addition, the evolution of the technique for proteomic analyses is described.
openaire +3 more sources
Future of cancer immunotherapy using plant virus-based nanoparticles
Future Science OA, 2019 Immunotherapy potentiates a patient’s immune response against some forms of cancer, including malignant tumors. In this Special Report, we have summarized the use of nanoparticles that have been designed for use in cancer immunotherapy with particular ...
Erum Shoeb, Kathleen Hefferon
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Understanding the T cell immune response in SARS coronavirus infection
Emerging Microbes and Infections, 2012 The severe acute respiratory syndrome (SARS) epidemic started in late 2002 and swiftly spread across 5 continents with a mortality rate of around 10%.
Hsueh-Ling Janice Oh +3 more
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Recent Progress Towards a Gonococcal Vaccine
Frontiers in Cellular and Infection Microbiology, 2022 Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection.
Stavros A. Maurakis +1 more
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Determination of a predictive cleavage motif for eluted major histocompatibility complex class II ligands [PDF]
, 2018 CD4+ T cells have a major role in regulating immune responses. They are activated by recognition of peptides mostly generated from exogenous antigens through the major histocompatibility complex (MHC) class II pathway.
Dhanda, Sandeep Kumar +7 more
core +6 more sources
Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus
Frontiers in Immunology, 2020 Hepatitis B virus (HBV) is a global virus responsible for a universal disease burden for millions of people. Various vaccination strategies have been developed using viral vector, nucleic acid, protein, peptide, and virus-like particles (VLPs) to ...
Saeed Mobini +4 more
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Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
Frontiers in Immunology, 2021 In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering +5 more
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Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]
, 1992 Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine +49 more
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Current Opinion in Immunology, 1996 Epitope (determinant) spreading is the development of immune responses to endogenous epitopes secondary to the release of self antigens during a chronic autoimmune or inflammatory response. The past year has seen considerable advances in our understanding of the contribution of epitope spreading to the chronic pathogenesis of experimental T-cell ...
Vanderlugt, Carol J, Miller, Stephen D
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