Prediction and validation of murine MHC class I epitopes of the recombinant virus VSV-GP
Frontiers in Immunology, 2023 Oncolytic viruses are currently tested as a novel platform for cancer therapy. These viruses preferentially replicate in and kill malignant cells. Due to their microbial origin, treatment with oncolytic viruses naturally results in anti-viral responses ...
Saskia V. Vijver +11 more
doaj +1 more source
Frontiers in Immunology, 2021 The adaptive immune system in vertebrates has evolved to recognize non-self antigens, such as proteins expressed by infectious agents and mutated cancer cells.
William D. Chronister +15 more
doaj +1 more source
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Science, 2020 Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan +7 more
semanticscholar +1 more source
TITAN: T Cell Receptor Specificity Prediction with Bimodal Attention Networks [PDF]
Bioinformatics 37 (2021): i237-i244, 2021 Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing of TCRs and their antigenic targets (epitopes), allowing to research the missing link between TCR sequence and epitope ...
arxiv +1 more source
Incorporation of T-cell epitopes from tetanus and diphtheria toxoids into in-silico-designed hypoallergenic vaccine may enhance the protective immune response against allergens [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): New generation of allergy vaccines is capable of promoting the development of protective IgG and blocking the functionality of allergen-specific IgE. We incorporated universal and powerful T-cell epitopes from tetanus and diphtheria toxoids
Ali Ghasemi +5 more
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Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Science, 2020 Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections.
Ellen L. Shrock +45 more
semanticscholar +1 more source
Broadly neutralizing antibodies target a haemagglutinin anchor epitope
Nature, 2021 Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1.
Jenna J. Guthmiller +32 more
semanticscholar +1 more source
BeeTLe: A Framework for Linear B-Cell Epitope Prediction and Classification [PDF]
, 2023 The process of identifying and characterizing B-cell epitopes, which are the portions of antigens recognized by antibodies, is important for our understanding of the immune system, and for many applications including vaccine development, therapeutics, and diagnostics.
arxiv +1 more source
Journal of Medical Virology, 2020 Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV. The situation is getting worse and worse, therefore, there is an urgent need for
M. Bhattacharya +7 more
semanticscholar +1 more source
In silico proof of principle of machine learning-based antibody design at unconstrained scale
mAbs, 2022 Generative machine learning (ML) has been postulated to become a major driver in the computational design of antigen-specific monoclonal antibodies (mAb).
Rahmad Akbar +18 more
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