Results 11 to 20 of about 607,096 (382)

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]

, 2013
The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I., Battella, Simone, Bonvin, Alexandre M. J. J., Davis, David, El Khattabi, Mohamed, Favier, Adrien, Forsman Quigley, Anna, Hinz, Andreas, Hock, Miriam, Hulsik, David Lutje, Langedijk, Johannes P. M., Liu, Ying-ying, Macheboeuf, Pauline, McCoy, Laura E., Poignard, Pascal, Ramos, Alejandra, Rutten, Lucy, Sabin, Charles, Seaman, Michael S., Simorre, Jean-Pierre, Strokappe, Nika M., Verrips, C. Theo, Weiss, Robin A., Weissenhorn, Winfried   +23 more
core   +23 more sources

BepiPred‐3.0: Improved B‐cell epitope prediction using protein language models

bioRxiv, 2022
B-cell epitope prediction tools are of great medical and commercial interest due to their practical applications in vaccine development. The introduction of protein language models (LM) trained on unprecedented large datasets of protein sequences and ...
Joakim Clifford, M. H. Høie, Morten Nielsen, Sebastian N Deleuran, B. Peters, P. Marcatili   +5 more
semanticscholar   +1 more source

Deep learning predictions of TCR-epitope interactions reveal epitope-specific chains in dual alpha T cells

bioRxiv, 2023
T cells have the ability to eliminate infected and cancer cells and play an essential role in cancer immunotherapy. T-cell activation is elicited by the binding of the T-cell receptor (TCR) to epitopes displayed on MHC molecules, and the TCR specificity ...
Giancarlo Croce, S. Bobisse, D. Moreno, J. Schmidt, Philippe Guillame, A. Harari, D. Gfeller   +6 more
semanticscholar   +1 more source

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

Science, 2020
Targeting the SARS-CoV-2 spike The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors.
M. Yuan, N. Wu, Xueyong Zhu, C. D. Lee, R. T. So, Huibin Lv, C. K. Mok, I. Wilson   +7 more
semanticscholar   +1 more source

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Science, 2020
Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections.
Ellen Shrock, Ellen Shrock, Eric Fujimura, Eric Fujimura, Tomasz Kula, Tomasz Kula, Richard T. Timms, Richard T. Timms, I-Hsiu Lee, Yumei Leng, Yumei Leng, M. Robinson, Brandon M Sie, Brandon M Sie, Mamie Z. Li, Mamie Z. Li, Yuezhou Chen, J. Logue, Adam Zuiani, Denise J. McCulloch, Felipe J. N. Lelis, Stephanie N. Henson, Daniel R. Monaco, M. Travers, S. Habibi, W. Clarke, P. Caturegli, Oliver Laeyendecker, Oliver Laeyendecker, A. Piechocka-Trocha, Jonathan Z. Li, A. Khatri, H. Chu, A. Villani, Kyle R. Kays, M. Goldberg, N. Hacohen, M. Filbin, Xu G. Yu, Bruce D. Walker, Bruce D. Walker, D. Wesemann, H. B. Larman, J. Lederer, S. Elledge, S. Elledge   +45 more
semanticscholar   +1 more source

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Nature, 2021
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1.
Jenna J. Guthmiller, Julianna Han, Henry A. Utset, Lei Li, L. Lan, Carole J Henry, Christopher T. Stamper, Meagan McMahon, George O’Dell, M. Fernández-Quintero, Alec W. Freyn, F. Amanat, O. Stovicek, Lauren E. Gentles, Sara T. Richey, A. T. de la Peña, Victoria C. Rosado, H. Dugan, Nai-Ying Zheng, Micah E. Tepora, Dalia J. Bitar, Siriruk Changrob, Shirin Strohmeier, Min Huang, A. García-Sastre, K. Liedl, J. Bloom, Raffael Nachbagauer, P. Palese, F. Krammer, Lynda Coughlan, A. Ward, P. Wilson   +32 more
semanticscholar   +1 more source

Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

Journal of Medical Virology, 2020
Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV. The situation is getting worse and worse, therefore, there is an urgent need for
M. Bhattacharya, Ashish Ranjan Sharma, Prasanta Patra, Pratik Ghosh, Garima Sharma, Bidhan Chandra Patra, Sang-Soo Lee, C. Chakraborty   +7 more
semanticscholar   +1 more source

A candidate multi-epitope vaccine against SARS-CoV-2

Scientific Reports, 2020
In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively.
Tamalika Kar, Utkarsh Narsaria, Srijita Basak, Debashrito Deb, F. Castiglione, D. Mueller, A. Srivastava   +6 more
semanticscholar   +1 more source

The Immune Epitope Database (IEDB): 2018 update

Nucleic Acids Res., 2018
The Immune Epitope Database (IEDB, iedb.org) captures experimental data confined in figures, text and tables of the scientific literature, making it freely available and easily searchable to the public. The scope of the IEDB extends across immune epitope
R. Vita, Swapnil Mahajan, James A. Overton, Sandeep Kumar Dhanda, Sheridan Martini, Jason R. Cantrell, D. Wheeler, A. Sette, Bjoern Peters   +8 more
semanticscholar   +1 more source

Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study

Journal of Biomolecular Structure and Dynamics, 2020
At present, novel Coronavirus (2019-nCoV, the causative agent of COVID-19) has caused worldwide social and economic disruption. The disturbing statistics of this infection promoted us to develop an effective vaccine candidate against the COVID-19.
Maryam Enayatkhani, Mehdi Hasaniazad, Sobhan Faezi, Hamed Guklani, P. Davoodian, Nahid Ahmadi, Mohammad Ali Einakian, A. Karmostaji, K. Ahmadi   +8 more
semanticscholar   +1 more source