Food Science and Human Wellness, 2023 Quail egg ovomucoid can inhibit activation of basophils and eosinophils, while hen egg ovomucoid has been shown to be a major allergen, named Gal d 1. At present, the differences in structure and function between two ovomucoid are unclear.
Mengzhen Hao +3 more
doaj +1 more source
The Immune Epitope Database (IEDB): 2018 update
Nucleic Acids Res., 2018 The Immune Epitope Database (IEDB, iedb.org) captures experimental data confined in figures, text and tables of the scientific literature, making it freely available and easily searchable to the public. The scope of the IEDB extends across immune epitope
R. Vita +8 more
semanticscholar +1 more source
Selection of neutralizing antibody escape mutants with type A influenza virus HA-specific polyclonal antisera: possible significance for antigenic drift [PDF]
, 1997 Ten antisera were produced in rabbits by two or three intravenous injections of inactivated whole influenza type A virions. All contained haemagglutination-inhibition (HI) antibody directed predominantly to an epitope in antigenic site B and, in addition,
Cleveland, S. Matthew +2 more
core +2 more sources
Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection
Frontiers in Immunology, 2018 Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral ...
Maximilian Koblischke +8 more
doaj +1 more source
Thermal and Acidic Treatments of Gluten Epitopes Affect Their Recognition by HLA-DQ2 in silico
Frontiers in Nutrition, 2021 Celiac disease (CD) is a prevalent disorder with autoimmune features. Dietary exposure of wheat gluten (including gliadins and glutenins) to the small intestine activates the gluten-reactive CD4+ T cells and controls the disease development.
Jihui Gao +13 more
doaj +1 more source
An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study
Scientific Reports, 2020 The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical therapy,
Zikun Yang, P. Bogdan, Shahin Nazarian
semanticscholar +1 more source
Characterization and epitope mapping of human monoclonal antibodies to PDC-E2, the immunodominant autoantigen of primary biliary cirrhosis [PDF]
, 1992 Further to define the epitopes of PDC-E2, the major autoantigen in primary biliary cirrhosis (PBC), we have developed and characterized five human monoclonal antibodies. These antibodies were derived by fusing a regional hepatic lymph node from a patient
Bassendine +49 more
core +1 more source
The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus
Vaccines, 2022 After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies ...
Jazmín García-Machorro +3 more
doaj +1 more source
Annual Review of Immunology, 2020 Throughout the body, T cells monitor MHC-bound ligands expressed on the surface of essentially all cell types. MHC ligands that trigger a T cell immune response are referred to as T cell epitopes.
Bjoern Peters, M. Nielsen, A. Sette
semanticscholar +1 more source
Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]
, 2009 Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Aho +69 more
core +2 more sources