Results 21 to 30 of about 591,359 (390)

Computational Design of a Novel VLP-Based Vaccine for Hepatitis B Virus

Frontiers in Immunology, 2020
Hepatitis B virus (HBV) is a global virus responsible for a universal disease burden for millions of people. Various vaccination strategies have been developed using viral vector, nucleic acid, protein, peptide, and virus-like particles (VLPs) to ...
Saeed Mobini, Milad Chizari, Ladan Mafakher, Elmira Rismani, Elham Rismani   +4 more
doaj   +1 more source

A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen [PDF]

, 2012
NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8⁺T cell epitope, NY-ESO-1<sub&
Ashley J. Knights, Emmanuel Scotet, Eugene Maraskovsky, Heather M. Jackson, Ian D. Davis, Immanuel F. Luescher, Jonathan Cebon, Kok-Fei Chan, Kun Xiao, Neil C. Robson, Nektaria Dimopoulos, Nicole A. Mifsud, Philippe Guillaume, Rona Y. Zhao, Sara Oveissi, Sarah E. Russell, Sylvie Le Gall, Tamara Lowen, Weisan Chen   +18 more
core   +17 more sources

Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Frontiers in Immunology, 2020
Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans.
Marion Tarbe, Marion Tarbe, Wei Dong, Guang Hu, Guang Hu, Yongfen Xu, Yongfen Xu, Jing Sun, Solene Grayo, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Li Liu, Xiuzhen Li, Xiuzhen Li, Qibin Leng, Qibin Leng, Qibin Leng   +19 more
doaj   +1 more source

The Advantage of Using Immunoinformatic Tools on Vaccine Design and Development for Coronavirus

Vaccines, 2022
After the outbreak of SARS-CoV-2 by the end of 2019, the vaccine development strategies became a worldwide priority. Furthermore, the appearances of novel SARS-CoV-2 variants challenge researchers to develop new pharmacological or preventive strategies ...
Jazmín García-Machorro, Gema Lizbeth Ramírez-Salinas, Marlet Martinez-Archundia, José Correa-Basurto   +3 more
doaj   +1 more source

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Science, 2020
Profiling coronaviruses Among the coronaviruses that infect humans, four cause mild common colds, whereas three others, including the currently circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), result in severe infections.
Ellen L. Shrock, Ellen L. Shrock, Eric Fujimura, Eric Fujimura, Tomasz Kula, Tomasz Kula, R. Timms, R. Timms, I-Hsiu Lee, Yumei Leng, Yumei Leng, M. Robinson, Brandon M. Sie, Brandon M. Sie, Mamie Z. Li, Mamie Z. Li, Yuezhou Chen, J. Logue, Adam Zuiani, Denise J. McCulloch, Felipe J. N. Lelis, Stephanie N. Henson, Daniel R. Monaco, M. Travers, S. Habibi, W. Clarke, P. Caturegli, O. Laeyendecker, O. Laeyendecker, A. Piechocka-Trocha, Jonathan Z. Li, A. Khatri, H. Chu, A. Villani, Kyle R. Kays, M. Goldberg, N. Hacohen, M. Filbin, Xu G. Yu, B. Walker, B. Walker, D. Wesemann, H. B. Larman, J. Lederer, S. Elledge, S. Elledge   +45 more
semanticscholar   +1 more source

A Method for Screening Proteases That Can Specifically Hydrolyze the Epitope AA83-105 of α_s1-Casein Allergen

Foods, 2022
Milk protein hydrolysates are common in infant formula, but some of them retain allergenicity due to incomplete hydrolysis of the epitopes for milk allergens.
Di Liu, Xiaozhe Lv, Yanjun Cong, Linfeng Li   +3 more
doaj   +1 more source

The CD8+ and CD4+ T Cell Immunogen Atlas of Zika Virus Reveals E, NS1 and NS4 Proteins as the Vaccine Targets

Viruses, 2022
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from virus structural and nonstructural proteins, and contributed to the viral clearance or protective immunity.
Hangjie Zhang, Wenling Xiao, Min Zhao, Yingze Zhao, Yongli Zhang, Dan Lu, Shuangshuang Lu, Qingxu Zhang, Weiyu Peng, Liumei Shu, Jie Zhang, Sai Liu, Kexin Zong, Pengyan Wang, Beiwei Ye, Shihua Li, Shuguang Tan, Fuping Zhang, Jianfang Zhou, Peipei Liu, Guizhen Wu, Xuancheng Lu, George F. Gao, William J. Liu   +23 more
doaj   +1 more source

Broadly neutralizing antibodies target a haemagglutinin anchor epitope

Nature, 2021
Broadly neutralizing antibodies that target epitopes of haemagglutinin on the influenza virus have the potential to provide near universal protection against influenza virus infection1.
Jenna J. Guthmiller, Julianna Han, Henry A. Utset, Lei Li, L. Lan, Carole J Henry, Christopher T. Stamper, Meagan McMahon, George O’Dell, M. Fernández-Quintero, Alec W. Freyn, F. Amanat, O. Stovicek, Lauren E. Gentles, Sara T. Richey, A. T. de la Peña, Victoria C. Rosado, H. Dugan, Nai-Ying Zheng, Micah E. Tepora, Dalia J. Bitar, Siriruk Changrob, Shirin Strohmeier, Min Huang, A. García-Sastre, K. Liedl, J. Bloom, Raffael Nachbagauer, P. Palese, F. Krammer, Lynda Coughlan, A. Ward, P. Wilson   +32 more
semanticscholar   +1 more source

In Silico Prediction of Cross-Reactive Epitopes of Tropomyosin from Shrimp and Other Arthropods Involved in Allergy

Molecules, 2022
Tropomyosin in shellfish is considered a major cross-reactive allergen in house dust mites and cockroaches; however, the specific epitopes have not been elucidated. Therefore, this study aimed to identify the consensus antigenic determinant among shrimp,
Jirakrit Saetang, Varomyalin Tipmanee, Soottawat Benjakul   +2 more
doaj   +1 more source

Development of epitope‐based peptide vaccine against novel coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach

Journal of Medical Virology, 2020
Recently, a novel coronavirus (SARS‐COV‐2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS‐CoV and MERS‐CoV. The situation is getting worse and worse, therefore, there is an urgent need for
M. Bhattacharya, Ashish Ranjan Sharma, Prasanta Patra, Pratik Ghosh, Garima Sharma, Bidhan Chandra Patra, Sang-Soo Lee, C. Chakraborty   +7 more
semanticscholar   +1 more source