Results 21 to 30 of about 552,242 (397)

A candidate multi-epitope vaccine against SARS-CoV-2

Scientific Reports, 2020
In the past two decades, 7 coronaviruses have infected the human population, with two major outbreaks caused by SARS-CoV and MERS-CoV in the year 2002 and 2012, respectively.
Tamalika Kar, Utkarsh Narsaria, Srijita Basak, Debashrito Deb, F. Castiglione, D. Mueller, A. Srivastava   +6 more
semanticscholar   +1 more source

The epitope recognized by rituximab [PDF]

Blood, 2006
AbstractRituximab is a monoclonal antibody widely used in the treatment of malignant lymphoma and autoimmunity. Its epitope within the B-cell antigen CD20 is largely unknown. We used phage display libraries to select peptides binding to rituximab. Enriched peptides showed 2 sequence patterns: one motif (CALMIANSC) is related to (170)ANPS(173) within ...
Binder, Mascha, Otto, Florian, Mertelsmann, Roland, Veelken, Hendrik, Trepel, Martin   +4 more
openaire   +5 more sources

Reverse vaccinology approach to design a novel multi-epitope vaccine candidate against COVID-19: an in silico study

Journal of Biomolecular Structure and Dynamics, 2020
At present, novel Coronavirus (2019-nCoV, the causative agent of COVID-19) has caused worldwide social and economic disruption. The disturbing statistics of this infection promoted us to develop an effective vaccine candidate against the COVID-19.
Maryam Enayatkhani, Mehdi Hasaniazad, Sobhan Faezi, Hamed Guklani, P. Davoodian, Nahid Ahmadi, Mohammad Ali Einakian, A. Karmostaji, K. Ahmadi   +8 more
semanticscholar   +1 more source

Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes

Frontiers in Immunology, 2021
In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4+ T cells in the NOD mouse and human
Stuart I. Mannering, Stuart I. Mannering, Alan F. Rubin, Alan F. Rubin, Ruike Wang, Pushpak Bhattacharjee   +5 more
doaj   +1 more source

Immobilization by surface conjugation of cyclic peptides for effective mimicry of the HCV-envelope E2 protein as a strategy toward synthetic vaccines [PDF]

, 2018
Mimicry of the binding interface of antibody-antigen interactions using peptide-based modulators (i.e. epitope mimics) has promising applications for vaccine design.
Dunlop, James I., Liskamp, Rob M.J., Meuleman, Theodorus J., Owsianka, Anna M., Patel, Arvind H., van de Langemheen, Helmus   +5 more
core   +2 more sources

Recent Progress Towards a Gonococcal Vaccine

Frontiers in Cellular and Infection Microbiology, 2022
Gonorrhea is a global health concern. Its etiological agent, Neisseria gonorrhoeae, rapidly acquires antimicrobial resistance and does not confer protective immunity as a consequence of infection.
Stavros A. Maurakis, Cynthia Nau Cornelissen   +1 more
doaj   +1 more source

The Immune Epitope Database (IEDB): 2018 update

Nucleic Acids Res., 2018
The Immune Epitope Database (IEDB, iedb.org) captures experimental data confined in figures, text and tables of the scientific literature, making it freely available and easily searchable to the public. The scope of the IEDB extends across immune epitope
R. Vita, Swapnil Mahajan, James A. Overton, Sandeep Kumar Dhanda, Sheridan Martini, Jason R. Cantrell, D. Wheeler, A. Sette, Bjoern Peters   +8 more
semanticscholar   +1 more source

Structural Influence on the Dominance of Virus-Specific CD4 T Cell Epitopes in Zika Virus Infection

Frontiers in Immunology, 2018
Zika virus (ZIKV) has recently caused explosive outbreaks in Pacific islands, South- and Central America. Like with other flaviviruses, protective immunity is strongly dependent on potently neutralizing antibodies (Abs) directed against the viral ...
Maximilian Koblischke, Karin Stiasny, Stephan W. Aberle, Stefan Malafa, Georgios Tsouchnikas, Julia Schwaiger, Michael Kundi, Franz X. Heinz, Judith H. Aberle   +8 more
doaj   +1 more source

Evaluation of Spike Protein Epitopes by Assessing the Dynamics of Humoral Immune Responses in Moderate COVID-19

Frontiers in Immunology, 2022
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike protein (S) of SARS-CoV-2 is a major target for diagnosis and vaccine development because of ...
Lingyun Chen, Lingyun Chen, Pengfei Pang, Huan Qi, Keqiang Yan, Keqiang Yan, Yan Ren, Mingliang Ma, Ruyin Cao, Hua Li, Chuansheng Hu, Yang Li, Jun Xia, Jun Xia, Danyun Lai, Yuliang Dong, Hewei Jiang, Hainan Zhang, Hong Shan, Shengce Tao, Siqi Liu, Siqi Liu   +21 more
doaj   +1 more source

CD4+ T-cell responses to Epstein-Barr virus (EBV) latent-cycle antigens and the recognition of EBV-transformed lymphoblastoid cell lines [PDF]

, 2005
There is considerable interest in the potential of Epstein-Barr virus (EBV) latent antigen-specific CD4\(^+\) T cells to act as direct effectors controlling EBV-induced B lymphoproliferations.
Brooks, J., Gudgeon, N. H., Haigh, T. A., Houssaint, E., Landais, E., Lee, S. P., Leen, A. M., Long, H. M., Rickinson, A. B., Taylor, G. S., Tsang, C.-W.   +10 more
core   +2 more sources