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Evolution of cytotoxic T-lymphocyte epitopes in hepatitis B virus
Infection, Genetics and Evolution, 2007 In hepatitis B virus (HBV), while mutations that escape from cytotoxic T-lymphocyte (CTL) recognition have been described it has been difficult to determine how natural selection by host CTL has influenced long-term evolution of HBV. We used statistical analysis of published HBV genomic sequences to examine the role of natural selection in evolution of
Austin L. Hughes, Kristi M. Westover
openaire +2 more sources
Host Genetics and Viral Diversity: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a workshop in September 2009 to discuss human and viral genetic variation and its impact on future directions for HIV vaccine research and development.
Andrew McMichael +2 more
core +3 more sources
Designing a Multi-Epitope Vaccine against Toxoplasma gondii: An Immunoinformatics Approach
Vaccines, 2022 Infection with the intracellular apicomplexan parasite Toxoplasma gondii causes serious clinical outcomes in both human and veterinary settings worldwide. Although approximately one-third of the world’s population is infected with T. gondii, an effective
Mutiat Hammed-Akanmu +7 more
doaj +1 more source
Presentation of an Immunodominant Immediate-Early CD8+ T Cell Epitope Resists Human Cytomegalovirus Immunoevasion. [PDF]
, 2013 Control of human cytomegalovirus (HCMV) depends on CD8+ T cell responses that are shaped by an individual's repertoire of MHC molecules. MHC class I presentation is modulated by a set of HCMV-encoded proteins.
Ameres, Stefanie +6 more
core +3 more sources
Virology, 2002 Yellow fever virus (YFV) is a re-emerging problem despite the existence of an effective live-attenuated vaccine. The induction of YFV-neutralizing antibodies undoubtedly contributes to vaccine efficacy, but T lymphocyte responses to YFV likely play a ...
M. Co +4 more
semanticscholar +1 more source
PASD1: a promising target for the immunotherapy of haematological malignancies [PDF]
, 2013 In general, there is a lack of good immunotherapy targets within the spectrum of haematological malignancies. However haematopoietic stem cell transplants and continuing antigen discovery have allowed further insight into how further improvements in ...
Denniss, Frances +4 more
core +2 more sources
Quantitative Prediction of Linear B-Cell Epitopes [PDF]
Biomedical Statistics and Informatics. Vol. 2, No.1, 2017, pp.1-3, 2017 In scientific literature, there are many programs that predict linear B-cell epitopes from a protein sequence. Each program generates multiple B-cell epitopes that can be individually studied. This paper defines a function called
arxiv +1 more source
HLA-Associated viral mutations are common in human immunodeficiency virus type 1 elite controllers [PDF]
, 2009 Elite controllers (EC) of human immunodeficiency virus type 1 (HTV-1) maintain viremia below the limit of detection without antiretroviral treatment. Virus-specific cytotoxic CD8+ T lymphocytes are believed to play a crucial role in viral containment ...
Block, B. L. +10 more
core +2 more sources
Informatics in Medicine Unlocked, 2023 Cryptosporidiosis is a zoonotic parasitic infection causing diarrhea in humans and farm animals. The present study was done to computationally analyze the Cryptosporidium parvum sporozoite glycoprotein antigen (SGA) regarding immunogenic epitopes, as a ...
Bahareh Kordi +6 more
doaj
Vaccines, 2023 Background: Latent tuberculosis infection (LTBI) is the primary source of active tuberculosis (ATB), but a preventive vaccine against LTBI is lacking. Methods: In this study, dominant helper T lymphocyte (HTL), cytotoxic T lymphocyte (CTL), and B-cell ...
Fan Jiang +5 more
doaj +1 more source