Results 131 to 140 of about 5,351 (235)

Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders

Ibrain
N6‐methyladenosine (m6A), the most abundant internal modification in mammalian mRNA, plays a critical role in cognitive function by dynamically regulating gene expression. This narrative review examines m6A's role in cognitive processes and its potential
Ting Liu, Xiao‐Juan Yang, Lin Zhou, Mi Gan, Ting‐Ting He, Sen Hong, Yan‐Yan Feng, Gao Su, You‐Xiao Zhao, Ying Cao, Qing‐Fan Zeng   +10 more
doaj   +1 more source

The epitranscriptomic writer ALKBH8 drives tolerance and protects mouse lungs from the environmental pollutant naphthalene

Epigenetics, 2020
The epitranscriptomic writer Alkylation Repair Homolog 8 (ALKBH8) is a transfer RNA (tRNA) methyltransferase that modifies the wobble uridine of selenocysteine tRNA to promote the specialized translation of selenoproteins.
Andrea Leonardi, Nataliia Kovalchuk, Lei Yin, Lauren Endres, Sara Evke, Steven Nevins, Samuel Martin, Peter C. Dedon, J. Andres Melendez, Laura Van Winkle, Qing-Yu Zhang, Xinxin Ding, Thomas J. Begley   +12 more
doaj   +1 more source

Long-read sequencing in the era of epigenomics and epitranscriptomics

Nature Methods, 2023
M. Lucas, E. Novoa
semanticscholar   +1 more source

Introduction to ‘The Epitranscriptome’

RSC Chemical Biology
Ralph Kleiner (Princeton University, USA), Claudia Höbartner (University of Würzburg, Germany) and Guifang Jia (Peking University, China) introduce the themed collection on ‘The Epitranscriptome’.
Kleiner, Ralph E., Höbartner, Claudia, Jia, Guifang   +2 more
openaire   +2 more sources

Unraveling the dual role of METTL3-mediated m6A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications

Cancer Biology & Therapy
Bladder cancer (BC) remains challenging due to its recurrence and metastasis, with METTL3-mediated m6 A RNA modification emerging as a key oncogenic driver. This review synthesizes METTL3’s roles in BC progression, including tumor initiation, metastasis,
Hua Chun, Kangzhuo Baima
doaj   +1 more source

From RNA and its NAD-cap: Exploring T4 phage infection from an epitranscriptomic perspective [PDF]

Bacteriophages are viruses with the ability to specifically infect and kill bacteria. Bacteriophage research has shaped our understanding of fundamental biological principles and provided tools for molecular biology, but it has long been forgotten. Thus,
Wolfram-Schauerte, Maik
core   +1 more source

N6-methyladenosine RNA modifications in myogenesis / narrative competence and cognitive mapping as a culturally sustaining pedagogy in the education of emergent bilinguals [PDF]

, 2022
Myogenesis involves skeletal muscle stem cells (MuSCs) that produce and regenerate skeletal muscle during regular growth and repair. However, when this system fails to function normally, it can lead to musculoskeletal diseases like Duchenne Muscular ...
Infantado, Marina Danielle
core   +1 more source

The epitranscriptome and synaptic plasticity

Current Opinion in Neurobiology, 2019
RNA modifications, collectively referred to as 'the epitranscriptome,' have recently emerged as a pervasive feature of cellular mRNAs which have diverse impacts on gene expression. In the last several years, technological advances improving our ability to identify mRNA modifications, coupled with the discovery of proteins that add and remove these ...
Mathieu N Flamand, Kate D Meyer
openaire   +3 more sources

Epitranscriptomic regulations in the heart

Physiological Research
RNA modifications affect key stages of the RNA life cycle, including splicing, export, decay, and translation. Epitranscriptomic regulations therefore significantly influence cellular physiology and pathophysiology. Here, we selected some of the most abundant modifications and reviewed their roles in the heart and in cardiovascular diseases: N6 ...
Benák, D. (Daniel), Kolář, F. (František), Hlaváčková, M. (Markéta)   +2 more
openaire   +3 more sources

Science of omics: a molecular space odyssey

Experimental Physiology, EarlyView.
Salomé Coppens, Christophe Hirtz, Margaux Vignon, Damian M. Bailey   +3 more
wiley   +1 more source