Results 141 to 150 of about 5,351 (235)

Emerging role of m6A modification in ovarian cancer: progression, drug resistance, and therapeutic prospects

open access: yesFrontiers in Oncology
Ovarian Cancer (OC) ranks as a prominent contributor to mortality among female reproductive system associated cancers, particularly the prevalent subtype epithelial Ovarian Cancer (EOC).
Shahil Alam, Pankaj Kumar Giri
doaj   +1 more source

Metabolomics of microRNAs in cardiovascular events in patients with obesity: a systematic review [PDF]

open access: yes
Introduction: In the metabolomics scenario of obesity and cardiovascular disease, epitranscriptomics establishes a novel mechanism of post-transcriptional RNA regulation. There is growing evidence supporting the role of intra- and extracellular microRNAs
Cruz, Daniella Bandim   +4 more
core   +2 more sources

Epitranscriptomic RNA m6A Modification in Cancer Therapy Resistance: Challenges and Unrealized Opportunities

open access: yesAdvanced Science
Significant advances in the development of new cancer therapies have given rise to multiple novel therapeutic options in chemotherapy, radiotherapy, immunotherapy, and targeted therapies.
Mohammad Burhan Uddin   +2 more
doaj   +1 more source

CHEMICAL SYNTHESIS AND BIOLOGICAL APPLICATION OF SENSITIVE RNA [PDF]

open access: yes
In the field of epigenetics - the dynamic collection of chemical modifications that overlay DNA/RNA - there is increasing interest in the potential for therapeutic and research-based utilization of the epitranscriptomics: those epigenetic modifications ...
Apostle, Alexander T.
core   +2 more sources

Intelligence of Matter: Rise of a New Style of Doing Science and Scientific Thinking?

open access: yesSystems
From Galileo’s conviction that the Universe is written in the language of mathematics to the genomic and computational revolutions of the twentieth century, science has long sought to describe nature through external symbolic systems.
Timir Tripathi   +2 more
doaj   +1 more source

Epitranscriptome regulation [PDF]

open access: yesNature Structural & Molecular Biology, 2018
Dominissini, Dan, Rechavi, Gideon
openaire   +1 more source

Unveil Intrahepatic Cholangiocarcinoma Heterogeneity through the Lens of Omics and Multi-Omics Approaches [PDF]

open access: yes
Simple Summary Intrahepatic cholangiocarcinoma (iCCA) is a highly aggressive primary liver cancer leading to death in 10-15% of cases. In recent years, the iCCA worldwide incidence has been increasing, and research is currently focused on identifying ...
Barbagallo, Cristina   +8 more
core   +1 more source

Integrative multi-omic profiling of the chronically hypoxic heart: focus on m6A and m6Am epitranscriptomic regulation

open access: yesFrontiers in Cell and Developmental Biology
Reduced oxygen availability is an environmental factor characteristic of high-altitude conditions that plays a critical role in shaping cellular homeostasis and epigenomic regulation.
Marketa Hlavackova   +10 more
doaj   +1 more source

Nanopore-m6A-finder, a novel m6A site caller for Nanopore DRS data

open access: yesFrontiers in Genetics
IntroductionN6-methyladenosine (m6A) is a pivotal RNA modification involved in diverse biological and pathological processes. Compared to the m6A detection methods based on second-generation sequencing, Nanopore direct RNA sequencing (DRS) offers the ...
Yuening Yang   +7 more
doaj   +1 more source

Sex-dependent serotonergic signaling across development: molecular mechanisms shaping vulnerability to neurodevelopmental and mental disorders

open access: yesFrontiers in Pharmacology
Psychiatric disorders and several neurodevelopmental conditions, including autism spectrum disorder, display marked sex biases in prevalence, symptom profiles, and treatment response.
Nicolás Palacios-Avendaño   +3 more
doaj   +1 more source

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