Results 211 to 220 of about 5,351 (235)
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ACS Nano, 2021
Reprograming the N6-methyladenosine (m6A) landscape is a promising therapeutic strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) of different aspect ratios using a binary surfactant mixture of ...
Yangyang Du +9 more
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Reprograming the N6-methyladenosine (m6A) landscape is a promising therapeutic strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) of different aspect ratios using a binary surfactant mixture of ...
Yangyang Du +9 more
semanticscholar +1 more source
N6-methyladenosine–encoded epitranscriptomics
Nature Structural & Molecular Biology, 2016N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic mRNA. Recent discoveries of the locations, functions and mechanisms of m6A have shed light on a new layer of gene regulation at the RNA level, giving rise to the field of m6A epitranscriptomics. In this Perspective, we provide an update on the various effects of mammalian
Nian, Liu, Tao, Pan
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Bioinformatic tools for epitranscriptomics
American Journal of Physiology-Cell Physiology, 2023The epitranscriptome, defined as RNA modifications that do not involve alterations in the nucleotide sequence, is a popular topic in the genomic sciences. Because we need massive computational techniques to identify epitranscriptomes within individual transcripts, many tools have been developed to infer epitranscriptomic sites as well as to process ...
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Resolving m6A epitranscriptome with stoichiometry
Trends in Genetics, 2022A recent study by Hu et al. describes N6-methyladenosine (m6A)-selective allyl chemical labeling and sequencing (m6A-SAC-seq), which allows for quantitative, stoichiometric, and positional analyses of m6A at single-nucleotide resolution across the whole transcriptome level.
Ki-Jun Yoon, Yoon Ki Kim
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Detection techniques for epitranscriptomic marks
American Journal of Physiology-Cell Physiology, 2022Similar to epigenetic DNA modification, RNA can be methylated and altered for stability and processing. RNA modifications, namely, epitranscriptomes, involve the following three functions: writing, erasing, and reading of marks. Methods for measurement and position detection are useful for the assessment of cellular function and human disease ...
Ken Ofusa +2 more
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Epitranscriptomics and cervical cancer: the emerging role of m6A, m5C and m1A RNA modifications
Expert Reviews in Molecular MedicineCervical cancer (CC), one of the most prevalent and detrimental gynaecologic cancers, evolves through genetic and epigenetic alterations resulting in the promotion of oncogenic activity and dysfunction of tumour-suppressing mechanisms.
Akshat D. Modi +3 more
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Epitranscriptomic Mass Spectrometry
Every chemical group that is added to any one of the canonical ribonucleotides in a transcript would create a specific RNA modification. Currently, 170+ RNA modifications have been identified. A specific epitranscriptome refers to all the RNA modifications in a given biological system and is considered to play an important role in the regulations of ...Hongzhou, Wang +3 more
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Epitranscriptomics and Diseases
2021The role of epitranscriptomics, i.e., RNA base modification, as a component of a “methylome” in disease has emerged as a result of the development of next generation sequencing and other related state-of-art technologies. Epitranscriptomic state is controlled by writing, erasing, and reading methylation, which is mediated by enzymatic reactions.
Masamitsu Konno, Hideshi Ishii
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2022
Several chemical modifications in cellular RNAs have been identified to date. The most common internal modification of eukaryotic RNAs is known as m6A. This modification is able to configure the outcome of gene expression by adjusting RNA decay, translation efficiency, RNA structure and alternative splicing.
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Several chemical modifications in cellular RNAs have been identified to date. The most common internal modification of eukaryotic RNAs is known as m6A. This modification is able to configure the outcome of gene expression by adjusting RNA decay, translation efficiency, RNA structure and alternative splicing.
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Metabolic Regulation of the Epitranscriptome
ACS Chemical Biology, 2019An emergent theme in cancer biology is that dysregulated energy metabolism may directly influence oncogenic gene expression. This is due to the fact that many enzymes involved in gene regulation use cofactors derived from primary metabolism, including acetyl-CoA, S-adenosylmethionine, and 2-ketoglutarate.
Justin M. Thomas +2 more
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