Results 201 to 210 of about 5,351 (235)

Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration

Cell Reports
Intramembranous ossification, a major bone development process, begins with the condensation of precursor cells through the timely structural adaption of extracellular matrix (ECM) catering to rapid cellular morphological changes.
Kunyu Zhang, ZHUO LI, Xian XIE
exaly   +2 more sources

Resolving sequencing-based HIV-1 epitranscriptomics

Epigenomics
The collection of HIV-1 RNA chemical modifications and their functional consequences in viral gene expression, host interactions, and the viral life cycle, referred to as HIV-1 epitranscriptomics, remain incompletely understood.
Michael S. Bosmeny, João I. Mamede, Keith T. Gagnon   +2 more
exaly   +2 more sources

Epitranscriptomics in fibroblasts and fibrosis.

American Journal of Physiology-Cell Physiology, 2022
Fibroblasts play an important role in the pathogenic mechanisms of several socially significant diseases, including pulmonary and cardiovascular fibrosis, liver cirrhosis, systemic sclerosis, progressive kidney disease.
M. Ilieva, S. Uchida
semanticscholar   +4 more sources

Epitranscriptomics in metabolic disease

Nature Metabolism, 2023
While epigenetic modifications of DNA and histones play main roles in gene transcription regulation, recently discovered post-transcriptional RNA modifications, known as epitranscriptomic modifications, have been found to have a profound impact on gene expression by regulating RNA stability, localization and decoding efficiency.
Y. Matsumura, Fan-Yan Wei, J. Sakai
semanticscholar   +3 more sources

Environmental epitranscriptomics [PDF]

Environmental Research, 2020
Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6 ...
Akin Cayir, Hyang-Min Byun, Timothy M Barrow   +2 more
exaly   +5 more sources

Detecting the epitranscriptome

WIREs RNA, 2021
AbstractRNA modifications and their corresponding epitranscriptomic writer and eraser enzymes regulate gene expression. Altered RNA modification levels, dysregulated writers, and sequence changes that disrupt epitranscriptomic marks have been linked to mitochondrial and neurological diseases, cancer, and multifactorial disorders.
Anwesha Sarkar, William Gasperi, Ulrike Begley, Steven Nevins, Sabrina M. Huber, Peter C. Dedon, Thomas J. Begley   +6 more
openaire   +2 more sources

The epitranscriptome beyond m6A

Nature Reviews Genetics, 2020
Following its transcription, RNA can be modified by >170 chemically distinct types of modifications - the epitranscriptome. In recent years, there have been substantial efforts to uncover and characterize the modifications present on mRNA, motivated by the potential of such modifications to regulate mRNA fate and by discoveries and advances in our ...
David Wiener, Schraga Schwartz
openaire   +2 more sources

Epitranscriptomic technologies and analyses

Science China Life Sciences, 2020
RNA can interact with RNA-binding proteins (RBPs), mRNA, or other non-coding RNAs (ncRNAs) to form complex regulatory networks. High-throughput CLIP-seq, degradome-seq, and RNA-RNA interactome sequencing methods represent powerful approaches to identify biologically relevant ncRNA-target and protein-ncRNA interactions.
Xiaoyu, Li, Qiao-Xia, Liang, Jin-Ran, Lin, Jinying, Peng, Jian-Hua, Yang, Chengqi, Yi, Yang, Yu, Qiangfeng Cliff, Zhang, Ke-Ren, Zhou   +8 more
openaire   +2 more sources

Epitranscriptomics in atherosclerosis: Unraveling RNA modifications, editing and splicing and their implications in vascular disease.

Vascular pharmacology
Atherosclerosis remains a leading cause of morbidity and mortality worldwide, driven by complex molecular mechanisms involving gene regulation and post-transcriptional processes.
V. Stopa, Dimitra Dafou, Korina Karagianni, A. Y. Nossent, Rosienne Farrugia, Yvan Devaux, M. Sopić   +6 more
semanticscholar   +1 more source

Exploring epitranscriptomics for crop improvement and environmental stress tolerance.

Plant physiology and biochemistry : PPB, 2022
Climate change and stressful environmental conditions severely hamper crop growth, development and yield. Plants respond to environmental perturbations, through their plasticity provided by key-genes, governed at post-/transcriptional levels.
Xiangbo Yang, Suraj Patil, Shrushti Joshi, Monica Jamla, Vinay Kumar   +4 more
semanticscholar   +1 more source