Results 181 to 190 of about 2,699 (211)

SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer

Molecular Cell, 2023
A common mRNA modification is 5-methylcytosine (m5C), whose role in gene-transcript processing and cancer remains unclear. Here, we identify serine/arginine-rich splicing factor 2 (SRSF2) as a reader of m5C and impaired SRSF2 m5C binding as a potential ...
Martin Bizet, Pascale Putmans, Rachel Deplus   +2 more
exaly   +2 more sources

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Detecting the epitranscriptome

WIREs RNA, 2021
AbstractRNA modifications and their corresponding epitranscriptomic writer and eraser enzymes regulate gene expression. Altered RNA modification levels, dysregulated writers, and sequence changes that disrupt epitranscriptomic marks have been linked to mitochondrial and neurological diseases, cancer, and multifactorial disorders.
Anwesha Sarkar, William Gasperi, Ulrike Begley, Steven Nevins, Sabrina M. Huber, Peter C. Dedon, Thomas J. Begley   +6 more
openaire   +2 more sources

Bioinformatic tools for epitranscriptomics

American Journal of Physiology - Cell Physiology, 2023
The epitranscriptome, defined as RNA modifications that do not involve alterations in the nucleotide sequence, is a popular topic in the genomic sciences. Because we need massive computational techniques to identify epitranscriptomes within individual transcripts, many tools have been developed to infer epitranscriptomic sites as well as to process ...
Y-H Taguchi
exaly   +3 more sources

The rise of epitranscriptomics: recent developments and future directions [PDF]

Trends in Pharmacological Sciences
The epitranscriptomics field has undergone tremendous growth since the discovery that the RNA N6-methyladenosine (m6A) modification is reversible and is distributed throughout the transcriptome.
Guo-Li Ming, Hongjun Song, Chuan He
exaly   +2 more sources

Epitranscriptomics in fibroblasts and fibrosis

American Journal of Physiology-Cell Physiology, 2022
Fibroblasts play an important role in the pathogenic mechanisms of several socially significant diseases, including pulmonary and cardiovascular fibrosis, liver cirrhosis, systemic sclerosis, progressive kidney disease. The alterations of the epitranscriptome, including more than 170 distinct posttranscriptional RNA modifications or editing events ...
Mirolyuba Ilieva, Shizuka Uchida
openaire   +3 more sources

Epitranscriptomics in metabolic disease

Nature Metabolism, 2023
While epigenetic modifications of DNA and histones play main roles in gene transcription regulation, recently discovered post-transcriptional RNA modifications, known as epitranscriptomic modifications, have been found to have a profound impact on gene expression by regulating RNA stability, localization and decoding efficiency.
Yoshihiro Matsumura, Fan-Yan Wei, Juro Sakai   +2 more
openaire   +2 more sources

Epitranscriptomic technologies and analyses

Science China Life Sciences, 2020
RNA can interact with RNA-binding proteins (RBPs), mRNA, or other non-coding RNAs (ncRNAs) to form complex regulatory networks. High-throughput CLIP-seq, degradome-seq, and RNA-RNA interactome sequencing methods represent powerful approaches to identify biologically relevant ncRNA-target and protein-ncRNA interactions.
Xiaoyu, Li, Qiao-Xia, Liang, Jin-Ran, Lin, Jinying, Peng, Jian-Hua, Yang, Chengqi, Yi, Yang, Yu, Qiangfeng Cliff, Zhang, Ke-Ren, Zhou   +8 more
openaire   +2 more sources

Metabolic Regulation of the Epitranscriptome

ACS Chemical Biology, 2019
An emergent theme in cancer biology is that dysregulated energy metabolism may directly influence oncogenic gene expression. This is due to the fact that many enzymes involved in gene regulation use cofactors derived from primary metabolism, including acetyl-CoA,  S-adenosylmethionine, and 2-ketoglutarate.
Justin M. Thomas, Pedro J. Batista, Jordan L. Meier   +2 more
openaire   +2 more sources

The epitranscriptome beyond m6A

Nature Reviews Genetics, 2020
Following its transcription, RNA can be modified by >170 chemically distinct types of modifications - the epitranscriptome. In recent years, there have been substantial efforts to uncover and characterize the modifications present on mRNA, motivated by the potential of such modifications to regulate mRNA fate and by discoveries and advances in our ...
David Wiener, Schraga Schwartz
openaire   +2 more sources

Deciphering the Epitranscriptome in Cancer

Trends in Cancer, 2018
Technological and methodological advancements have recently revolutionized our understanding of widespread epitranscriptome including RNA modifications and editing. N6-methyladenosine (m6A) represents the most prevalent internal modification in mammalian RNAs. Adenosine to inosine (A-to-I) RNA editing is an important mechanism underlying RNA generation
Hao, Lian, Qin-Hua, Wang, Chang-Bin, Zhu, Jie, Ma, Wei-Lin, Jin   +4 more
openaire   +2 more sources