Results 91 to 100 of about 1,305,585 (286)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]

, 2020
IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear, Adrienne W. Paton, Amin-Wetzel, Bertolotti, Bertolotti, Calfon, Chang, Delphine De Sutter, Eva Cloots, Feldman, Haber, Heidi De Luca, Hetz, Hollien, Hollien, Imagawa, Iwawaki, Iwawaki, James C. Paton, Jay R. Thiagarajah, Karagöz, Lee, Li, Lisbona, Lu, Mariska S. Simpson, Markus A. Seeliger, Martino, Mi, Michael J. Grey, Miyoshi, Nicole LeDuc, Paton, Paton, Phi Luong, Prischi, Sepulveda, Shemorry, Singh, Sophie Janssens, Sundaram, Sven Eyckerman, Tam, Tirasophon, Tirasophon, Tschurtschenthaler, Tsuru, Tsuru, Walter, Wang, Wang, Wayne I. Lencer, Wiseman, Yevgeniy V. Serebrenik, Yoshida   +54 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Developmental hypomyelination in Wolfram syndrome: New insights from neuroimaging and gene expression analyses [PDF]

, 2019
Wolfram syndrome is a rare multisystem disorder caused by mutations in WFS1 or CISD2 genes leading to brain structural abnormalities and neurological symptoms. These abnormalities appear in early stages of the disease.
Dougherty, Joseph, Hershey, Tamara, Marshall, Bess, Neyman, Olga, Park, Ki Yun, Rahn, Rachel, Samara, Ahmad, Samara, Amjad   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

ER stress and hepatic lipid metabolism

Frontiers in Genetics, 2014
The endoplasmic reticulum (ER) is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as ER stress, has been linked to numerous pathological conditions, such as inflammation, cardiovascular ...
Huiping eZhou, Huiping eZhou, Runping eLiu   +2 more
doaj   +1 more source

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Role of Endoplasmic Reticulum Stress in Cardiovascular Disease and Exercise

International Journal of Vascular Medicine, 2017
Endoplasmic reticulum (ER) stress, which is highly associated with cardiovascular disease, is triggered by a disturbance in ER function because of protein misfolding or an increase in protein secretion.
Junyoung Hong, Kwangchan Kim, Jong-Hee Kim, Yoonjung Park   +3 more
doaj   +1 more source

Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis

Molecular Medicine, 2020
Background Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mechanism of cerebral I/R injury ...
Xiaowei Sun, Hao Liu, Zhongren Sun, Beng Zhang, Xinyu Wang, Tingting Liu, Tingting Pan, Ying Gao, Xicheng Jiang, Hongtao Li   +9 more
doaj   +1 more source