Results 91 to 100 of about 1,296,012 (206)

Heme Oxygenase-1 Reduces Sepsis-Induced Endoplasmic Reticulum Stress and Acute Lung Injury

Mediators of Inflammation, 2018
Background. Sepsis leads to severe acute lung injury/acute respiratory distress syndrome (ALI/ARDS) that is associated with enhanced endoplasmic reticulum (ER) stress.
Xiaozhen Chen, Yinglin Wang, Xiang Xie, Hongfei Chen, Qiqi Zhu, Zhidong Ge, Hua Wei, Jingshong Deng, Zhengyuan Xia, Qingquan Lian   +9 more
doaj   +1 more source

LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes

Cell Reports, 2019
Summary: LACC1 genetic variants are associated with multiple immune-mediated diseases. However, laccase domain containing-1 (LACC1) functions are incompletely defined.
Chen Huang, Matija Hedl, Kishu Ranjan, Clara Abraham   +3 more
doaj   +1 more source

Messenger RNA targeting to endoplasmic reticulum stress signalling sites. [PDF]

, 2009
Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic cells lead to ER stress and trigger the unfolded protein response (UPR).
Aragón, Tomás, Korennykh, Alexei V, Pincus, David, Rubio, Claudia A, Serafimova, Iana M, van Anken, Eelco, Walter, Peter   +6 more
core  

Understanding the Role of Phosphoinositide 3-Kinase and its Function as a Driving Force behind the ER Stress Response in Fibrostenotic Crohn’s Disease-affected Ileal Smooth Muscle Cells [PDF]

, 2018
Crohn’s disease (CD) affects about 780,000 people in the United States alone, and it is estimated that 6-15 per 100,000 persons will receive a diagnosis of this disease each year.
Yadav, Prashant
core   +1 more source

Evidence of Endoplasmic Reticulum Stress Mediating Cell Death in Transplanted Human Islets

Cell Transplantation, 2012
A key limitation to the success of islet transplantation is islet cell exhaustion and cell death during islet isolation and following transplantation. Endoplasmic reticulum (ER) stress has been identified as an important mechanism in the development of β-
Sarita Negi, Soon Hyang Park, Arif Jetha, Reid Aikin, Michel Tremblay, Steven Paraskevas M.D., Ph.D.   +5 more
doaj   +1 more source

神経系小胞体ストレスと誘導型アポトーシスのニコチンとニューロトロフィンによる防御機構 [PDF]

, 2007
Neuronal degenerative diseases including Alzheimer\u27s, Parkinson\u27s and polyglutamine diseases are considered to involve endoplasmic reticulum (ER) stress, which leads to ER stress-mediated apoptosis of some neurons. In the process of these diseases,
Ikeuchi Toshihiko, Shimoke Koji, 下家 浩二, 池内 俊彦   +3 more
core   +1 more source

Endoplasmic reticulum stress and oxidative imbalance is the missing link in fibromyalgia pathophysiology

Scientific Reports
Fibromyalgia syndrome (FMS) is a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, and cognitive dysfunction. Although its exact pathophysiology remains unclear, emerging evidence suggests that endoplasmic reticulum (ER ...
Önder Otlu, Tuğba Raika Kıran, Rabia Aydoğan Baykara, Mehmet Erdem, Feyza İnceoğlu   +4 more
doaj   +1 more source

Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion Injury.

PLoS ONE, 2015
We examined whether endoplasmic reticulum (ER) stress-induced autophagy provides cytoprotection from renal tubular epithelial cell injury due to oxidants and chemical hypoxia in vitro, as well as from ischemia-reperfusion (IR) injury in vivo.
Bhavya B Chandrika, Cheng Yang, Yang Ou, Xiaoke Feng, Djamali Muhoza, Alexandrea F Holmes, Sue Theus, Sarika Deshmukh, Randy S Haun, Gur P Kaushal   +9 more
doaj   +1 more source

ER stress and cancer [PDF]

Cancer Biology & Therapy, 2006
Amy S, Lee, Linda M, Hendershot
openaire   +2 more sources

Novel roles of ER stress in repressing neural activity and seizures through Mdm2- and p53-dependent protein translation.

PLoS Genetics, 2019
Seizures can induce endoplasmic reticulum (ER) stress, and sustained ER stress contributes to neuronal death after epileptic seizures. Despite the recent debate on whether inhibiting ER stress can reduce neuronal death after seizures, whether and how ER ...
Dai-Chi Liu, Daphne E Eagleman, Nien-Pei Tsai   +2 more
doaj   +1 more source