Results 11 to 20 of about 1,296,012 (206)
Animal Cells and Systems, 2023 Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely undefined.
Joon Bum Kim +9 more
doaj +1 more source
IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. [PDF]
, 2013 We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress.
Lane, Timothy F +6 more
core +8 more sources
Diversification and deleterious role of microbiome in gastric cancer
Cancer Reports, 2023 Gut microbiota dictates the fate of several diseases, including cancer. Most gastric cancers (GC) belong to gastric adenocarcinomas (GAC). Helicobacter pylori colonizes the gastric epithelium and is the causative agent of 75% of all stomach malignancies ...
Indranil Chattopadhyay +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Alzheimer’s disease (AD) is the most common neurodegenerative disease, characterized by progressive cognitive impairment and memory loss. So far, the pathogenesis of AD has not been fully understood.
Xun Gao, Yuanyuan Xu
doaj +1 more source
Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT
Biomedicines, 2020 The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).
Rohit Gundamaraju +4 more
doaj +1 more source
Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis. [PDF]
, 2015 Palmitic acid (PA) induces hepatocyte apoptosis and fuels de novo ceramide synthesis in the endoplasmic reticulum (ER). Myristic acid (MA), a free fatty acid highly abundant in copra/palmist oils, is a predictor of nonalcoholic steatohepatitis (NASH) and
Alarcón-Vila, C +9 more
core +5 more sources
Frontiers in Cellular and Infection Microbiology, 2022 The normal operation of the endoplasmic reticulum (ER) is critical for cells and organisms. However, ER stress, caused by imbalanced protein folding, occurs frequently, which perturbs the function of the ER and even results in cell apoptosis eventually ...
Peng Xu, Jing Tang, Zheng-Guo He
doaj +1 more source
Antioxidants, 2021 In different pathological states that cause endoplasmic reticulum (ER) calcium depletion, altered glycosylation, nutrient deprivation, oxidative stress, DNA damage or energy perturbation/fluctuations, the protein folding process is disrupted and the ER ...
Yan Zhou +4 more
doaj +1 more source
ER Stress and Effects of DHA as an ER Stress Inhibitor [PDF]
Translational Stroke Research, 2013 The endoplasmic reticulum (ER) functions in the synthesis, folding, modification, and transport of newly synthesized transmembrane and secretory proteins. The ER also has important roles in the storage of intracellular Ca(2+) and regulation of Ca(2+) homeostasis.
Gulnaz, Begum +3 more
openaire +2 more sources
Cell Death Signaling From Endoplasmic Reticulum Stress: Plant-Specific and Conserved Features
Frontiers in Plant Science, 2022 The endoplasmic reticulum (ER) stress response is triggered by any condition that disrupts protein folding and promotes the accumulation of unfolded proteins in the lumen of the organelle.
Eduardo B. Simoni +4 more
doaj +1 more source