Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics [PDF]
Molecular Systems Biology, 2021 AbstractCombining single-cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an ERK biosensor to measure single-cell ERK dynamics.
Dessauges, Coralie +7 more
openaire +6 more sources
Overexpression of RASAL1 indicates poor prognosis and promotes invasion of ovarian cancer
Open Life Sciences, 2019 RAS protein activator like-1 (RASAL1) exists in numerous human tissues and has been commonly demonstrated to act as a tumor suppressor in several cancers. This study aimed to identify the functional characteristics of RASAL1 in ovarian adenocarcinoma and
Chang Rui-Xia +5 more
doaj +1 more source
ERK Signals: Scaffolding Scaffolds? [PDF]
Frontiers in Cell and Developmental Biology, 2016 ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of the module into a multi-enzymatic complex by which signal amplitude and duration are fine-tuned ...
Casar, Berta, Crespo, Piero
openaire +4 more sources
Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line [PDF]
, 2013 Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated
A Breit +73 more
core +7 more sources
Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression. [PDF]
, 2016 BackgroundNovel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models ...
Liu, Yin +4 more
core +2 more sources
S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis [PDF]
Scientific Reports, 2013 Extracellular signal-regulated kinase (ERK) belongs to the mitogen-activated protein kinases (MAPK) superfamily. Aberrant upregulation and activation of ERK cascades may often lead to tumor cell development. However, how ERK is involved in tumor progression is yet to be defined.
Xiujing Feng +6 more
openaire +2 more sources
p38 Mitogen-activated Protein Kinase Regulates Oscillation of Chick Pineal Circadian Clock [PDF]
, 2003 Extracellular signal-regulated kinase (ERK) and p38 are members of the mitogen-activated protein kinase (MAPK) family, and in some cases these kinases serve for closely related cellular functions within a cell. In a wide range of animal clock structures,
Fukada, Yoshitaka +4 more
core +1 more source
A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription
Cell Structure and FunctionExtracellular signal-regulated kinase (ERK) regulates multiple cellular functions through distinct activation patterns. Genetically encoded fluorescent probes are instrumental in dissecting the ERK activity dynamics in living cells.
Zhang Weisheng +4 more
doaj +1 more source
Pharmaceutical Biology, 2019 Context: Oxymatrine (OMT) has various pharmacological effects, including immune reaction regulation, anti-inflammation and anti-hypersensitive reaction.
Zhiqiang Zhang +4 more
doaj +1 more source
Acta Pharmaceutica, 2023 This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively ...
Liu Rui +4 more
doaj +1 more source