Results 31 to 40 of about 511,445 (325)
Optogenetic actuator – ERK biosensor circuits identify MAPK network nodes that shape ERK dynamics [PDF]
Molecular Systems Biology, 2021 AbstractCombining single-cell measurements of ERK activity dynamics with perturbations provides insights into the MAPK network topology. We built circuits consisting of an optogenetic actuator to activate MAPK signaling and an ERK biosensor to measure single-cell ERK dynamics.
Dessauges, Coralie +7 more
openaire +6 more sources
ERK Signals: Scaffolding Scaffolds? [PDF]
Frontiers in Cell and Developmental Biology, 2016 ERK1/2 MAP Kinases become activated in response to multiple intra- and extra-cellular stimuli through a signaling module composed of sequential tiers of cytoplasmic kinases. Scaffold proteins regulate ERK signals by connecting the different components of the module into a multi-enzymatic complex by which signal amplitude and duration are fine-tuned ...
Casar, Berta, Crespo, Piero
openaire +4 more sources
HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]
, 2010 Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan +54 more
core +1 more source
S-nitrosylation of ERK inhibits ERK phosphorylation and induces apoptosis [PDF]
Scientific Reports, 2013 Extracellular signal-regulated kinase (ERK) belongs to the mitogen-activated protein kinases (MAPK) superfamily. Aberrant upregulation and activation of ERK cascades may often lead to tumor cell development. However, how ERK is involved in tumor progression is yet to be defined.
Xiujing Feng +6 more
openaire +2 more sources
ERK-1 MAP kinase prevents TNF-induced apoptosis through bad phosphorylation and inhibition of bax translocation in HeLa cells [PDF]
, 2009 Extracellular signal-regulated kinase (ERK) 1/2 signaling is involved in tumor cell survival through the regulation of Bcl-2 family members. To explore this further and to demonstrate the central role of the mitochondria in the ERK1/2 pathway we used the
Aventaggiato, Michele +10 more
core +1 more source
The β-blocker Nebivolol Is a GRK/β-arrestin Biased Agonist [PDF]
, 2013 Nebivolol, a third generation β-adrenoceptor (β-AR) antagonist (β-blocker), causes vasodilation by inducing nitric oxide (NO) production. The mechanism via which nebivolol induces NO production remains unknown, resulting in the genesis of much of the ...
Andresen, Bradley T. +9 more
core +7 more sources
Pharmaceutical Biology, 2019 Context: Oxymatrine (OMT) has various pharmacological effects, including immune reaction regulation, anti-inflammation and anti-hypersensitive reaction.
Zhiqiang Zhang +4 more
doaj +1 more source
A sensitive ERK fluorescent probe reveals the significance of minimal EGF-induced transcription
Cell Structure and FunctionExtracellular signal-regulated kinase (ERK) regulates multiple cellular functions through distinct activation patterns. Genetically encoded fluorescent probes are instrumental in dissecting the ERK activity dynamics in living cells.
Zhang Weisheng +4 more
doaj +1 more source
Acta Pharmaceutica, 2023 This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively ...
Liu Rui +4 more
doaj +1 more source
Selective Desensitization of Growth Factor Signaling by Cell Adhesion to Fibronectin [PDF]
, 2007 Cell adhesion to the extracellular matrix is required to execute growth factor (GF)-mediated cell behaviors, such as proliferation. A major underlying mechanism is that cell adhesion enhances GF-mediated intracellular signals, such as extracellular ...
Asthagiri, Anand R. +3 more
core +1 more source