Endocrine Regulations, 2023 Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y. +8 more
doaj +1 more source
RNA Sequencing in Hypoxia-Adapted T98G Glioblastoma Cells Provides Supportive Evidence for IRE1 as a Potential Therapeutic Target. [PDF]
, 2023 Glioblastoma (GBM) is an aggressive brain cancer with a median survival time of 14.6 months after diagnosis. GBM cells have altered metabolism and exhibit the Warburg effect, preferentially producing lactate under aerobic conditions.
Buono, Russell +3 more
core +2 more sources
IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress [PDF]
, 2020 IRE1β is an ER stress sensor uniquely expressed in epithelial cells lining mucosal surfaces. Here, we show that intestinal epithelial cells expressing IRE1β have an attenuated unfolded protein response to ER stress.
Acosta-Alvear +54 more
core +1 more source
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology [PDF]
, 2021 © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org ...
Alves da Costa, Cristine +13 more
core +1 more source
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
core +2 more sources
Endocrine Regulations, 2022 Objective. The aim of the present study was to investigate the expression of pyruvate dehydrogenase genes such as PDHA1, PDHB, DLAT, DLD, and PDHX in U87 glioma cells in response to glutamine and glucose deprivations in control glioma cells and ...
Shatokhina Hanna O. +8 more
doaj +1 more source
Auxin Response Factor 2 (ARF2), ARF3, and ARF4 Mediate Both Lateral Root and Nitrogen Fixing Nodule Development in Medicago truncatula [PDF]
, 2021 Auxin Response Factors (ARFs) constitute a large family of transcription factors that mediate auxin-regulated developmental programs in plants. ARF2, ARF3, and ARF4 are post-transcriptionally regulated by the microRNA390 (miR390)/trans-acting small ...
BLANCO, Flavio +8 more
core +3 more sources
Endocrine Regulations, 2023 Objective. Homeobox genes play a fundamental role in the embryogenesis, but some of them have been linked to oncogenesis. The present study is aimed to investigate the impact of glucose and glutamine deprivations on the expression of homeobox genes such ...
Krasnytska Dariia O. +8 more
doaj +1 more source
ERN1 modifies the effect of glutamine deprivation on tumor growth related factors expression in U87 glioma cells [PDF]
The Ukrainian Biochemical Journal, 2018 The expression of a subset of genes encoding important tumor growth related factors in U87 glioma cells with ERN1 (endoplasmic reticulum to nucleus signaling 1) loss of function as well as upon glutamine deprivation was studied.
O. H. Minchenko +5 more
doaj +1 more source
TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation [PDF]
, 2016 Summary - Significant insights into disease pathogenesis have been gleaned from population-level genetic studies; however, many loci associated with complex genetic disease contain numerous genes, and phenotypic associations cannot be assigned ...
Bhan, Atul K. +16 more
core +3 more sources