Results 41 to 50 of about 1,604 (142)

Targeting mitochondrial stress with Szeto-Schiller 31 prevents experimental abdominal aortic aneurysm : Crosstalk with endoplasmic reticulum stress [PDF]

, 2023
Mitochondrial dysfunction and inflammation contribute to a myriad of cardiovascular diseases. Deleterious crosstalk of mitochondria and persistent endoplasmic reticulum (ER) stress triggers oxidative stress, which is involved in the development of ...
Navas Madroñal, Miquel, Almendra-Pegueros, Rafael, Puertas Umbert, Lídia, Jiménez Altayó, Francesc, Julve i Gil, Josep, Pérez, Belén, Consegal-Pérez, Marta, Kassan, M., Martínez-González, José, Rodriguez, Cristina, Galán, María   +10 more
core   +3 more sources

THE MULTIFACETED ROLE OF ENDOPLASMIC RETICULUM STRESS IN THE REGULATION OF GENE EXPRESSION IN NORMAL ASTROCYTES AND GLIOBLASTOMA CELLS [PDF]

Biotechnologia Acta
Aim. To determine the role of the endoplasmic reticulum (ER) in regulating gene expression in normal astrocytes and glioblastoma cells under the application of carbon nanoparticles as anti-tumor agents. Methods.
O.V. Rudnytska
doaj   +1 more source

The effects of graded levels of calorie restriction : XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome [PDF]

, 2017
We would like to acknowledge the BSU staff for their invaluable help with caring for the animals.Peer reviewedPublisher ...
Chen, Luonan, Derous, Davina, Douglas, Alex, Green, Cara L, Han, Jing-Dong J, Lusseau, David, Mitchell, Sharon E, Promislow, Daniel E L, Speakman, John R, Wang, Lu, Wang, Yingchun   +10 more
core   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source

New Visions on Natural Products and Cancer Therapy: Autophagy and Related Regulatory Pathways [PDF]

, 2022
Macroautophagy (autophagy) has been a highly conserved process throughout evolution and allows cells to degrade aggregated/misfolded proteins, dysfunctional or superfluous organelles and damaged macromolecules, in order to recycle them for biosynthetic ...
Brogi S., Calderone V., Citi V., da Silva Rosa S. C., Ghavami S., Grabarek B. O., Klionsky D. J., Lorzadeh S., Los M. J., Martelli A., Mehrbod P., Nabavi S. F., Nabavi S. M., Omrani M., Staszkiewicz R., Sureda A., Zarghooni M.   +16 more
core   +1 more source

Dynamic 3D chromatin organization and epigenetic regulation of gene expression in peanut nodules

Journal of Integrative Plant Biology, Volume 67, Issue 10, Page 2624-2642, October 2025.
A 3D genomic map of peanut nodules revealed that the nodules exhibit chromatin reorganization, with 2% of regions transitioning to active states, altered topologically associating domains and enhanced cis interactions. The identification of chromatin loops that regulate nodulation genes links 3D genome dynamics to symbiotic nitrogen fixation.
Lixiang Wang, Chunhai Mai, Suqin He, Bingjie Niu, Gaiya Jia, Tao Yang, Yiwei Xu, Meng Ren, Xiaorui Zhao, Xin Liu, Zhaosheng Kong   +10 more
wiley   +1 more source

Pro-Survival Factor EDEM3 Confers Therapy Resistance in Prostate Cancer [PDF]

, 2022
Prostate cancer is the most common cancer in men, and it is primarily driven by androgen steroid hormones. The glycosylation enzyme EDEM3 is controlled by androgen signalling and is important for prostate cancer viability.
Cheung, Kathleen, Duxfield, Adam, Elliott, David, Garnham, Rebecca, Munkley, Jennifer, Scott, Emma   +5 more
core   +3 more sources

Dopamine D1 Receptor Contributes to Glucocorticoid‐Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This work identifies a novel mechanism by which dopamine D1 receptor (DRD1) contributes to the pathogenesis of glucocorticoid (GC)‐associated osteonecrosis of the femoral head (ONFH) through the regulation of osteoblastic apoptosis, indicating that DRD1 serves as a critical mediator of the crosstalk between the nervous and skeletal systems.
Kai Zheng, Wenming Li, Tianhao Wang, Gaoran Ge, Wei Zhang, Yi Qin, Wenhao Li, Zebin Wu, Zhen Wang, Gang Rui, Yaozeng Xu, Dechun Geng   +11 more
wiley   +1 more source

Endoplasmic reticulum stress-dependent regulation of carboxypeptidase E expression in glioblastoma cells

Endocrine Regulations
Objective. Carboxypeptidase E (CPE) plays an important role in the biosynthesis of neurotransmitters and peptide hormones including insulin. It also promotes cell proliferation, survival, and invasion of tumor cells.
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khita Olena O., Sliusar Myroslava Y., Viletska Yuliia M., Minchenko Dmytro O.   +5 more
doaj   +1 more source

Reprogramming of root cells during nitrogen-fixing symbiosis involves dynamic polysome association of coding and noncoding RNAs [PDF]

, 2020
Translational control is a widespread mechanism that allows the cell to rapidly modulate gene expression in order to provide flexibility and adaptability to eukaryotic organisms.
Bailey Serres, Julia, Blanco, Flavio Antonio, Hobecker, Karen Vanesa, Hummel, Maureen, Lancia, Marcos, Reynoso, Mauricio Alberto, Rosen, Benjamin, Town, Christopher, Traubenik, Laura Soledad, Zanetti, María Eugenia   +9 more
core   +2 more sources