Results 51 to 60 of about 1,604 (142)

The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma

The Journal of Pathology, Volume 266, Issue 3, Page 247-257, July 2025.
Abstract The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were associated with chordomas and with the variant rs2305089 A‐allele with enrichment of the AA ...
Inga Usher, Paul O'Donnell, Lorena Ligammari, Dorothee Harder, Wendy Brown, David Choi, Paul Cool, Lucia Cottone, Adrienne M Flanagan   +8 more
wiley   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, Volume 19, Issue 6, Page 1687-1706, June 2025.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Orchestrating Neural Development Through mRNA Translation Regulation

Journal of Neurochemistry, Volume 169, Issue 6, June 2025.
This review provides an overview of mRNA translation mechanisms that control prenatal brain development, including cortical lamination, progenitor differentiation, and axon guidance, and identifies significant knowledge gaps. Specifically, we focus on mRNA translation regulation through signaling cascades such as the mammalian/mechanistic target of ...
Brandon Rodrigue, Mathew Sajish, Natalina Salmaso, Argel Aguilar‐Valles   +3 more
wiley   +1 more source

Endoplasmic reticulum stress-dependent regulation of the expression of serine hydroxymethyltransferase 2 in glioblastoma cells

Endocrine Regulations
Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis).
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O.   +6 more
doaj   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

Cytoprotective role of the fatty acid binding protein 4 against oxidative and endoplasmic reticulum stress in 3T3-L1 adipocytes

FEBS Open Bio, 2014
The fatty acid binding protein 4 (FABP4), one of the most abundant proteins in adipocytes, has been reported to have a proinflammatory function in macrophages. However, the physiological role of FABP4, which is constitutively expressed in adipocytes, has
Kazuaki Kajimoto, Yoshitaka Minami, Hideyoshi Harashima   +2 more
doaj   +1 more source

Mesenchymal Stem Cell‐Derived Exosomes: A Promising Therapeutic Strategy for Age‐Related Diseases

Cell Proliferation, Volume 58, Issue 5, May 2025.
Mechanisms of MSC‐Exos in the treatment of age‐related diseases. A Immunomodulatory and anti‐inflammatory, MSC‐Exos mediate immunomodulatory and anti‐inflammatory effects by regulating the polarisation of T cells and macrophages, promoting an anti‐inflammatory state while inhibiting pro‐inflammatory responses; B Suppression of oxidative stress, MSC ...
Bohua Wei, Mengting Wei, Haonan Huang, Ting Fan, Zhichang Zhang, Xiaoyu Song   +5 more
wiley   +1 more source

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis [PDF]

, 2021
Summary DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown.
Asby, R, Barrans, S, Beer, P, Blain, AE, Bornelov, S, Burke, GAA, Burton, C, Campbell, P, Cucco, F, De Los Mozos, IR, Du, M-Q, Forde, S, Gao, J, Giotopoulos, G, Gong, C, Grigoropoulos, NF, Haupl, B, Hodson, DJ, Huntly, BJ, Krupka, JA, Matthews, J, Meng, W, Oellerich, T, Painter, D, Rand, V, Roman, E, Samarajiwa, SA, Screen, M, Sze, SK, Tan, MGK, Tooze, R, Turner, M, Turner, SD, Ule, J, Usheva, Z, Zaini, NBM, Zhou, P   +36 more
core  

Multi Layered Omics Approaches Reveal Glia Specific Alterations in Alzheimer's Disease: A Systematic Review and Future Prospects

Glia, Volume 73, Issue 3, Page 539-573, March 2025.
Main Point Graphical overview of the literature summarized in this review, spanning glia cells and levels of omics analysis present on Alzheimer's disease. ABSTRACT Alzheimer's disease (AD) is the most common neurodegenerative dementia with multi‐layered complexity in its molecular etiology.
Özkan İş, Yuhao Min, Xue Wang, Stephanie R. Oatman, Ann Abraham Daniel, Nilüfer Ertekin‐Taner   +5 more
wiley   +1 more source

Exploring precision treatments in immune‐mediated inflammatory diseases: Harnessing the infinite potential of nucleic acid delivery

Exploration, Volume 5, Issue 1, February 2025.
Within this review, an in‐depth exploration of therapeutic nucleic acids and their delivery mechanisms in immune‐mediated inflammatory diseases (IMIDs) is presented. The review encapsulates key elements such as different types of nucleic acid molecules, delivery systems for nucleic acids, and the therapeutic use of nucleic acid delivery for IMIDs ...
Lingxiao Xu, Zhenxuan Shao, Xia Fang, Zengfeng Xin, Shenzhi Zhao, Hongbo Zhang, Yu Zhang, Wenbiao Zheng, Xiaohua Yu, Zengjie Zhang, Lingling Sun   +10 more
wiley   +1 more source