Results 131 to 140 of about 14,499 (192)
European Journal of Neurology, Volume 33, Issue 2, February 2026.Salivary Extracellular vesicles (SEVs) isolated from PD patients exhibit increased levels of both total (α‐SynTot) and oligomeric alpha‐synuclein (α‐SynOlig). In PD patients, SEVS‐α‐SynOlig levels correlate with cognitive decline (MMSE) and motor fluctuations (MDS‐UPDRS IV) and remain stable after 1 year follow‐up.
Antonia Gurgone +9 more
wiley +1 more source
Regulation of ligand-independent notch signal through intracellular trafficking [PDF]
, 2012 Notch signaling is an evolutionarily conserved mechanism that defines a key cell fate control mechanism in metazoans. Notch signaling relies on the surface interaction between the Notch receptor and membrane bound ligands in an apposing cell.
Artavanis-Tsakonas, Spyros +3 more
core +1 more source
Exosomes in Hypertrophic Scars and Keloids: Mechanisms and Therapeutic Potentials—A Narrative Review
Journal of Cosmetic Dermatology, Volume 25, Issue 2, February 2026.ABSTRACT Background Hypertrophic scars and keloids, types of pathological scars, arise from dysregulated wound healing, marked by abnormal fibroblast activation and excessive extracellular matrix (ECM) deposition. Current treatments have high recurrence rates and side effects, necessitating targeted therapies. Exosomes, extracellular vesicles mediating
Mengke Wu +6 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 2, 31 January 2026.Schematic workflow of plasma‐ and serum‐derived extracellular vesicle (EV) analysis in horses, including sample preparation, EV isolation using size‐exclusion chromatography (SEC) and ultracentrifugation (UC), vesicle characterization by nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM), and comparative proteomic profiling
Dominika Milczek‐Haduch +5 more
wiley +1 more source
Membrane remodelling by dynamic ESCRT-III polymers
, 2021 Multi-subunit ESCRT-III polymers together with the ATPase Vps4 have the unique ability to fission membrane necks from their luminal side, a process that is required for essential cellular functions like cell division and nuclear envelop maintenance.
openaire +2 more sources
ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity
Nature Communications, 2018 The endosomal sorting complex required for transport-III (ESCRT-III) has been implicated in the packaging of HIV and HSV-1 viruses in the cytoplasm. Here the authors show that ESCRT-III proteins are required for the transport of HSV-1 nucleocapsids from ...
Jun Arii +9 more
doaj +1 more source
Aspergillus nidulans ambient pH signaling does not require endocytosis
, 2015 9 p.-6 fig.-1 tab.Aspergillus nidulans (Pal) ambient pH signaling takes place in cortical structures containing components of the ESCRT pathway, which are hijacked by the alkaline pH-activated, ubiquitin-modified version of the arrestin-like protein PalF
Arst, HN +3 more
core +1 more source
Journal of VirologyThe endosomal sorting complex required for transport (ESCRT) is a protein machine mediating membrane scission. In intraluminal vesicle (ILV) formation, ESCRT-0 targets cargoes and recruits ESCRT-I/-II to create membrane invagination, whereas ESCRT-III ...
Xiaorong Yue +5 more
doaj +1 more source
Continuum Electromechanical Modeling of Protein-Membrane Interaction
, 2010 A continuum electromechanical model is proposed to describe the membrane curvature induced by electrostatic interactions in a solvated protein-membrane system.
Alemayehu A. Gorfe +4 more
core +1 more source
The Conserved ESCRT-III Machinery Participates in the Phagocytosis of Entamoeba histolytica
Frontiers in Cellular and Infection Microbiology, 2018 The endosomal sorting complex required for transport (ESCRT) orchestrates cell membrane-remodeling mechanisms in eukaryotes, including endocytosis. However, ESCRT functions in phagocytosis (ingestion of ≥250 nm particles), has been poorly studied.
Yunuen Avalos-Padilla +7 more
doaj +1 more source