Results 1 to 10 of about 118,174 (261)

Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis [PDF]

Frontiers in Immunology
Macrophages are the predominant immune cell type found in active multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) lesions, where they contribute to demyelination and axonal damage. Depending on the lesion stage, these cells can
Alexander Muselman, Lewis W. Yu, Khoa D. Nguyen, Mohammed Inayathullah, Qiang Liu, Kyle D. Brewer, Andrey V. Malkovskiy, Jayakumar Rajadas, Jayakumar Rajadas, Edgar G. Engleman, Edgar G. Engleman   +10 more
doaj   +2 more sources

Liraglutide Attenuates Disease Severity in Experimental Autoimmune Encephalomyelitis by Modulating Splenic T Helper Cell Subsets [PDF]

Brain and Behavior
Objective To investigate the therapeutic effects of liraglutide, a glucagon‐like peptide‐1 receptor agonist, on clinical progression and splenic T‐cell subsets in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis ...
Shuang Song, Bin Li, Ruoyi Guo, Yi Zhou, Yumei Xue, Li Guo   +5 more
doaj   +2 more sources

B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis [PDF]

Cellular and Molecular Life Sciences
N6-methyladenosine (m6A), the most prevalent RNA modification, plays a pivotal role in regulating mRNA metabolism and cellular processes such as immune responses.
Xuzhong Pei, Xiying Wang, Jie Ding, Haojun Yu, Chunran Xue, Chong Xie, Yi Chen, Xinyu Lin, Hong Yang, Yangtai Guan   +9 more
doaj   +2 more sources

Role of nuclear factor κB in multiple sclerosis and experimental autoimmune encephalomyelitis

Neural Regeneration Research, 2018
The transcription factor nuclear factor κB (NF-κB) plays major roles in inflammatory diseases through regulation of inflammation and cell viability. Multiple sclerosis (MS) is a chronic inflammatory demyelinating and neurodegenerative disease of the ...
Yuan Yue, Sarrabeth Stone, Wensheng Lin
doaj   +2 more sources

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

EMBO Molecular Medicine, 2014
Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler, Sarah Mundt, Tony Muchamuel, Carlo Moll, Jing Jiang, Marcus Groettrup, Christopher J. Kirk   +6 more
doaj   +2 more sources

Activity-attenuated serum albumin-fused interleukin-33 suppresses experimental autoimmune encephalomyelitis [PDF]

Cell Reports Medicine
Summary: Interleukin-33 (IL-33) is an immunoregulatory cytokine that moderately suppresses experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS).
Erica Budina, Joseph W. Reda, Shijie Cao, Elyse A. Watkins, Ani Solanki, Mindy Nguyen, Phillip S. Ang, J. Emiliano Gómez Medellín, Hye-Rin Chun, Colleen R. Foley, Brendan T.K. Berg, Ha-Na Shim, Kevin Hultgren, Zahra Khosravi, Arjun Dhar, Suzana Gomes, Andrew C. Tremain, Ako Ishihara, Jun Ishihara, Jeffrey A. Hubbell   +19 more
doaj   +2 more sources

Evaluation of methods of modeling and formation of experimental allergic encephalomyelitis [PDF]

Research Results in Pharmacology, 2022
Introduction: Experimental autoimmune (allergic) encephalomyelitis (EAE) induced by intradermal injection of homogenate of the brain, spinal cord and peripheral nerve with Freund’s stimulator, refers to a true autoimmune disease of the nervous system.
Oleksandr O. Nefodov, Igor F. Belenichev, Mykola P. Fedchenko, Olena O. Popazova, Victor P. Ryzhenko, Oksana V. Morozova   +5 more
doaj   +3 more sources

AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

Journal of Experimental Medicine, 2021
In this study, Ma et al. demonstrate that AIM2 negatively regulates the DNA-PK–AKT3 in microglia to control neuroinflammation synergistically induced by cGAS and DNA-PK, thereby preventing the pathogenesis of EAE independent of inflammasome activation.
Chunmei Ma, Sheng Li, Yingchao Hu, Yan Ma, Yuqing Wu, Chunyan Wu, Xue Liu, Bingwei Wang, G. Hu, Jia-wei Zhou, Shuo Yang   +10 more
semanticscholar   +1 more source

Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis [PDF]

, 2013
PMCID ...
A Compston, A Shetty, A Zimmer, AC Howlett, AE Bygrave, C Bolton, C Delarasse, C Delarasse, C Teuscher, Carolyn Tanner, CS Wu, CS Wu, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D McHugh, David Baker, David L. Selwood, DL Smith-Bouvier, E de Lago, E Kozela, E Montero, E Zurita, F Docagne, F Wu, G Disanto, G Musumeci, G Paltser, G Pryce, G Pryce, G Wotherspoon, Gareth Pryce, Gavin Giovannoni, Gregory J. Michael, H Kataoka, HM Vesterinen, I Mendel, J Corey-Bloom, J Karlsson, J Palazuelos, JA Encinas, JB Davis, JH Slingsby, JK O'Neill, JL Croxford, JL Croxford, JM Coquet, JP Zajicek, K Li, K Maresz, KM Spach, L Cristino, LM Olsson, LS Whyte, M Sundvall, M Webb, MF Festing, NA Balenga, NE Buckley, O Ofek, PC Staton, PD Fillmore, PM Hoi, RA Ross, RA Ross, RC Axtell, RG Pertwee, RG Pertwee, RJ Butterfield, Roberto Furlan, RS Graves, Ruth A. Ross, S Al-Izki, S Al-Izki, S Amor, S Amor, S Amor, S Katona, S Levine, S Levine, S Rossi, S Saadoun, Samuel J. Jackson, SC Landis, SJ Allen, Sofia Sisay, V Devonshire, Y Okuda, ZY Lou   +92 more
core   +12 more sources

MicroRNAs as disease progression biomarkers and therapeutic targets in experimental autoimmune encephalomyelitis model of multiple sclerosis

Neural Regeneration Research, 2020
Multiple sclerosis is an autoimmune neurodegenerative disease of the central nervous system characterized by pronounced inflammatory infiltrates entering the brain, spinal cord and optic nerve leading to demyelination.
Bridget Martinez, Philip V Peplow
doaj   +1 more source