Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis
EMBO Molecular Medicine, 2014 Multiple sclerosis (MS) is a chronic demyelinating immune mediated disease of the central nervous system. The immunoproteasome is a distinct class of proteasomes found predominantly in monocytes and lymphocytes. Recently, we demonstrated a novel function
Michael Basler +6 more
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In Vitro Effects of Phytohemagglutinin and Brain Antigen on Cell Transfer of Experimental Autoimmune Encephalomyelitis in Lewis Rats [PDF]
, 1968 Hans-Dieter Flad +2 more
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Glia, Volume 73, Issue 11, Page 2273-2288, November 2025.Main Points ER stress amplifies TNF‐α, OSM, and IL‐1β responses in astrocytes. PERK and JAK1 signaling are required for the synergistic interaction between ER stress and inflammatory cytokines. Translational suppression attenuates the synthesis of the negative feedback regulators IκBα and SOCS3.
Anirudhya Lahiri +8 more
wiley +1 more source
Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. [PDF]
, 1992 Samia J. Khoury +2 more
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Probiotics as a Complementary Medicine in Neurologic Disorders
Health Science Reports, Volume 8, Issue 11, November 2025.ABSTRACT Background and Aims Today, neurological and neuropsychiatric disorders, including depression, anxiety, Parkinson's disease (PD), Alzheimer's disease (AS), autism spectrum disorder (ASD), and multiple sclerosis (MS), contribute significantly to global disability and healthcare burden.
Mahla Jafari +5 more
wiley +1 more source
Translational utility of experimental autoimmune encephalomyelitis: recent developments
Journal of Inflammation Research, 2015 Andre Ortlieb Guerreiro-Cacais, Hannes Laaksonen, Sevasti Flytzani, Marie N'diaye, Tomas Olsson, Maja Jagodic Neuroimmunology Unit, Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden Abstract:
Guerreiro-Cacais AO +5 more
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Inhibition of experimental autoimmune encephalomyelitis by a nonimmunogenic non-self peptide that binds to I-Au. [PDF]
, 1992 Anand M. Gautam +5 more
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Aryl Hydrocarbon Receptor in Health and Disease
MedComm, Volume 6, Issue 11, November 2025.Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li +11 more
wiley +1 more source
Reducing suffering in experimental autoimmune encephalomyelitis (EAE)
Journal of Pharmacological and Toxicological Methods, 2013 This report is based on discussions and submissions from an expert working group consisting of veterinarians, animal care staff and scientists with expert knowledge relevant to the field. It aims to facilitate the implementation of the Three Rs (replacement, reduction and refinement) in the use of animal models or procedures involving experimental ...
Wolfensohn, SE +8 more
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Cell Reports, 2019 Summary: Noradrenaline (NE), the main neurotransmitter released by sympathetic nerve terminals, is known to modulate the immune response. However, the role of the sympathetic nervous system (SNS) on the development of autoimmune diseases is still unclear.
Leandro Pires Araujo +8 more
doaj +1 more source