Results 11 to 20 of about 83,143 (262)

Peptide immunotherapy in experimental autoimmune encephalomyelitis [PDF]

Biomedical Journal, 2015
We now have potent drugs available to treat the inflammatory component of multiple sclerosis (MS). However, not all patients respond, the drugs are not curative, and the associated risks to beneficial immune surveillance are considerable.
Stephen M Anderton
doaj   +3 more sources

Experimental autoimmune encephalomyelitis

Biomedical Journal, 2015
Jean Kanellopoulos
doaj   +3 more sources

Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. [PDF]

Glia
Acute intermittent hypoxia is a novel, noninvasive therapy that shows promising and similar beneficial repair and remyelination following demyelination in male experimental autoimmune encephalomyelitis, as was previously shown in female mice. ABSTRACT Multiple sclerosis (MS) affects women more frequently than men, but the disease progresses more ...
Tokarska N, Roberts J, Koralage SR, Naniong JMA, Johnston JM, Wei Z, Verge VMK.   +6 more
europepmc   +2 more sources

Experimental Autoimmune Encephalomyelitis (EAE) [PDF]

Current Protocols in Neuroscience, 2001
AbstractThe procedures described in this unit utilize murine models exclusively since murine EAE often results in a relapsing/remitting disease, similar to the early phase of most MS patients. EAE in the Lewis rat is a monophasic illness in which animals experience a single episode of paralysis from which most recover completely. This unit presents two
openaire   +3 more sources

Amelioration of experimental autoimmune encephalomyelitis by anatabine. [PDF]

PLoS ONE, 2013
Anatabine, a naturally occurring alkaloid, is becoming a commonly used human food supplement, taken for its claimed anti-inflammatory properties although this has not yet been reported in human clinical trials.
Daniel Paris, David Beaulieu-Abdelahad, Myles Mullan, Ghania Ait-Ghezala, Venkat Mathura, Corbin Bachmeier, Fiona Crawford, Michael J Mullan   +7 more
doaj   +1 more source

Contribution of pannexin1 to experimental autoimmune encephalomyelitis. [PDF]

PLoS ONE, 2013
Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that
Sarah E Lutz, Estibaliz González-Fernández, Juan Carlos Chara Ventura, Alberto Pérez-Samartín, Leonid Tarassishin, Hiromitsu Negoro, Naman K Patel, Sylvia O Suadicani, Sunhee C Lee, Carlos Matute, Eliana Scemes   +10 more
doaj   +1 more source

Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]

, 2016
Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai, Liu, Yan-Qun, Xie, Chong, Zhang, Guang-Xian   +3 more
core   +2 more sources

In Vivo and In Vitro Evidence for an Interplay between the Glucocorticoid Receptor and the Vitamin D Receptor Signaling

Cells, 2023
Our previous work demonstrated that vitamin D (VitD) reduces experimental autoimmune encephalomyelitis (EAE) disease severity in wild-type (WT) but not in T cell-specific glucocorticoid (GC) receptor (GR)-deficient (GRlck) mice.
Maud Bagnoud, Jana Remlinger, Marine Massy, Dmitri Lodygin, Anke Salmen, Andrew Chan, Fred Lühder, Robert Hoepner   +7 more
doaj   +1 more source

Emerging immunopharmacological targets in multiple sclerosis. [PDF]

, 2015
Inflammatory demyelination of the central nervous system (CNS) is the hallmark of multiple sclerosis (MS), a chronic debilitating disease that affects more than 2.5 million individuals worldwide. It has been widely accepted, although not proven, that the
Abdolmohamad Rostami, Abrams, Abrams, Achiron, Adelman, Allen, Bachmann, Bai, Bai, Baker, Balcer, Bar-Or, Bar-Or, Bar-Or, Bar-Or, Ben-Nun, Biasi, Bielekova, Bielekova, Bielekova, Bielekova, Bielekova, Bitar, Bluestone, Bogoljub Ciric, Bour-Jordan, Bourdette, Bourquin, Brambilla, Brocke, Burman, Burns, Burrows, Chaudhuri, Chitnis, Coles, Constantinescu, Constantinescu, Correale, Correale, Cox, Cragg, Crowe, Darlington, Darlington, Disanto, Duddy, Emery, Espinoza-Delgado, Faria, Faria, Farjam, Feinstein, Fissolo, Fletcher, Freedman, Garren, Garren, Garren, Garren, Giovannoni, Giovannoni, Girvin, Girvin, Goodin, Gosselin, Goverman, Goverman, Guang-Xian Zhang, Hale, Hartmann, Hauser, Havrdova, Hawker, He, Hedegaard, Higgins, Hill-Cawthorne, Hilliard, Hilliard, Ho, Hoffmann, Hofman, Jankovic, Jennum, Kappos, Kappos, Karussis, Karussis, Kearney, Kerbrat, Le Page, Li, Liblau, Lider, Lider, Lindsey, Lindsey, Lisak, Liu, Lobell, Lobell, Lohse, Lund, Lyons, Marrie, Marta, Martin, Mease, Medaer, Mestecky, Mikulkova, Miller, Milo, Mirshafiey, Mojtaba Farjam, Moreau, Mowat, Nicoletti, Nightingale, O'Brien, Offner, Offner, Oh, Oksenberg, Pender, Pettitt, Phillips, Phillips, Podojil, Poli, Pozzilli, Pryce, Quintana, Racioppi, Rasouli, Robinson, Rose, Rose, Rostami, Sandrini, Schaub, Sclerosis, Selmaj, Selmaj, Sinha, Smith, Spuler, Stuve, Taoufik, Tsunoda, Turley, Turley, Turner, van Boxel-Dezaire, van den Hoogen, Van der Walt, van Oosten, van Oosten, van Oosten, Vandenbark, Vandenbark, Viglietta, Viglietta, Vollmer, Walczak, Waldmann, Wang, Weber, Wefer, Weiner, Weiner, Weissert, Willis, Wucherpfennig, Wynn, Xing, Yadav, Zang, Zhang, Zhang, Zhang, Zhang   +182 more
core   +2 more sources

Silencing miR-150 Ameliorates Experimental Autoimmune Encephalomyelitis

Frontiers in Neuroscience, 2018
MiR-150 regulates maturation and differentiation of T cells but how it functions in multiple sclerosis (MS) is unclear. In miR-150 knockout (KO) mice, we examined the effect of miR-150 deletion on disease severity of experimental autoimmune ...
Zhaolan Hu, Yanhui Cui, Xiaoqing Qiao, Xinwen He, Fang Li, Cong Luo, Shuang Wang, Changqi Li, Ruping Dai   +8 more
doaj   +1 more source