Results 41 to 50 of about 81,192 (267)

Effect of oral genistein administration in early and late phases of allergic encephalomyelitis [PDF]

, 2014
Objective(s): Experimental allergic encephalomyelitis (EAE) is an autoimmune disease validated as animal model of multiple sclerosis (MS). Administration of genistein, a phytoestrogenic component of soy, to mice at the onset of EAE is known to attenuate ...
Alizadeh, A., Arrefhosseini, S.R., Ghaemi, A., Razeghi Jahromi, S., Sabetghadam, F., Togha, M.   +5 more
core   +1 more source

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

Expression of components involved in cholesterol homeostasis maintenance during experimental autoimmune encephalomyelitis in rat spinal cord

Folia Neuropathologica
Dysregulations in cholesterol homeostasis contribute to the pathogenesis of multiple sclerosis (MS) and its best described animal model, experimental autoimmune encephalomyelitis (EAE).
Smilja Todorovic, Katarina Milosevic, Ana Milosevic, Marija M. Janjic, Srdjan J. Sokanovic, Danijela Savic, Irena Lavrnja   +6 more
doaj   +1 more source

Analysis of Soluble Interleukin‐2 Receptor as a Prognostic Biomarker in NMOSD and MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Soluble interleukin‐2 receptor (sIL‐2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) pathogenesis. However, sIL‐2R has so far not been evaluated in these conditions.
Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann‐Strobl, Friedemann Paul, Patrick Schindler   +8 more
wiley   +1 more source

Studies in the Modulation of Experimental Autoimmune Encephalomyelitis [PDF]

Journal of Neuroimmune Pharmacology, 2010
Experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, can be induced through inoculation with several different central nervous system (CNS) proteins or peptides. Modulation of EAE, resulting in either protection from EAE or enhancement of EAE, can also be accomplished through either vaccination or DNA ...
Robert S. Fujinami, Jane E. Libbey, Ikuo Tsunoda   +2 more
openaire   +3 more sources

Behavioral investigation of mice with experimental autoimmune encephalomyelitis

Arquivos de Neuro-Psiquiatria, 2011
Multiple sclerosis is a neuroinflammatory disease that results in serious neurological disability. Besides physical impairment, behavioral symptoms are also common in patients with multiple sclerosis.
David Henrique Rodrigues, Márcia de Carvalho Vilela, Norinne Lacerda-Queiroz, Aline Silva de Miranda, Larissa Fonseca da Cunha Sousa, Helton José dos Reis, Antônio Lúcio Teixeira   +6 more
doaj   +1 more source

Emodin attenuates inflammation and demyelination in experimental autoimmune encephalomyelitis

Neural Regeneration Research, 2023
Emodin, a substance extracted from herbs such as rhubarb, has a protective effect on the central nervous system. However, the potential therapeutic effect of emodin in the context of multiple sclerosis remains unknown.
Yue-Ran Cui, Zhong-Qi Bu, Hai-Yang Yu, Li-Li Yan, Juan Feng   +4 more
doaj   +1 more source

Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]

, 2018
There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa, Kaufman, Daniel L, Olsen, Richard, Tian, Jide, Wallner, Martin   +4 more
core   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source