Results 81 to 90 of about 81,192 (267)

Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

eLife
Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF.
Joanna Kosinska, Julian C Assmann, Julica Inderhees, Helge Müller-Fielitz, Kristian Händler, Sven Geisler, Axel Künstner, Hauke Busch, Anna Worthmann, Joerg Heeren, Christian D Sadik, Matthias Gunzer, Vincent Prévot, Ruben Nogueiras, Misa Hirose, Malte Spielmann, Stefan Offermanns, Nina Wettschureck, Markus Schwaninger   +18 more
doaj   +1 more source

Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2018
Th17-lymphocytes are well known for their deleterious role in autoimmunity. But does the notoriety of this repertoire extend beyond autoimmunity? In the present study we employed experimental autoimmune encephalomyelitis as model system to study the role
Ravi Kant, Ravi Kant, Shweta Pasi, Shweta Pasi, Avadhesha Surolia, Avadhesha Surolia   +5 more
doaj   +1 more source

Review: ‘Gimme five’: future challenges in multiple sclerosis. ECTRIMS Lecture 2009 [PDF]

, 2010
This article is based on the ECTRIMS lecture given at the 25th ECTRIMS meeting which was held in Düsseldorf, Germany, from 9 to 12 September 2009. Five challenges have been identified: (1) safeguarding the principles of medical ethics; (2) optimizing the
Bartholomaus I., Ben-Nun A., Bennett JL, Bielekova B., Bradl M., Chabas D., De Jager PL, De Jager PL, Dornmair K., Ferguson B., Flügel A., Frischer JM, Gold R., Gregersen JW, Han MH, Hohlfeld R., Hohlfeld R., Junker A., Kerschensteiner M., Kerschensteiner M., Kinoshita M., Korn T., Krishnamoorthy G., Kuhlmann T., Kümpfel T., Kümpfel T., Kümpfel T., Lennon VA, Linington C., Lock C., Mathey EK, Misgeld T., Platten M., Pollinger B., Polman CH, Reinhard Hohlfeld, Schluesener HJ, Seitz S., Sobottka B., Stadelmann C., Trapp BD, Trapp BD, Wiendl H., Wiendl H., Zipp F.   +44 more
core   +1 more source

Comparative Cytokine and Histology Studies on HPV and Other Viral Vaccinations: No Pathogenicity of HPV Vaccine Adjuvants

Cancer Science, EarlyView.
Anti‐HPV vaccine activists claimed that aluminum (Al) adjuvants in HPV vaccines could cause immune abnormalities, leading to neurological diseases. We evaluated the cytokine and histology profiles following administrations of HPV vaccines and other viral vaccines containing adjuvants.
Reona Shiro, Fumitaka Sato, Seiichi Omura, Ah‐Mee Park, Cong Thanh Nguyen, Ijaz Ahmad, Sandesh Rimal, Koji Kinoshita, Noriomi Matsumura, Ikuo Tsunoda   +9 more
wiley   +1 more source

Organ-specific features of natural killer cells. [PDF]

, 2011
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical.
La Cava, Antonio, Ljunggren, Hans-Gustaf, Shi, Fu-Dong, Van Kaer, Luc   +3 more
core   +1 more source

Effect of time to initiation and dose of methylprednisolone on outcome in multiple sclerosis‐related optic neuritis

Clinical and Experimental Neuroimmunology, EarlyView.
Abstract Objectives It is known that the benefit of intravenous methylprednisolone (IVMP) in multiple sclerosis‐related optic neuritis (MS‐ON) is limited to an accelerated recovery. We aimed to evaluate the impact of time from symptoms onset to IVMP initiation and of IVMP dose on visual recovery among people with MS‐ON.
Hadar Gilad, Josepha Horowitz, Sivan Bloch, Daniel Golan   +3 more
wiley   +1 more source

Targeting ROCK1/YAP1 Axis Ameliorates Inflammation‐Induced Prostatic Hyperplasia via Stabilising SIRT1‐Dependent Mitochondrial Dynamics

Cell Proliferation, EarlyView.
Prostate‐specific YAP1 overexpression induces pathological BPH phenogenesis. Targeting ROCK1/YAP1 with fasudil and verteporfin alleviates inflammatory BPH lesions. YAP1 orchestrates mitochondrial dysfunction and oxidative stress via suppressing SIRT1 function.
Dongxu Lin, Pengyu Wei, Mengyang Zhang, Kang Li, Lina Li, Zhipeng Li, Changcheng Luo, Wenbo Kuang, Kai Cui, Zhong Chen   +9 more
wiley   +1 more source

Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. [PDF]

, 2007
Peroxisome proliferator-activated receptor (PPAR)alpha is a nuclear receptor that mediates gender differences in lipid metabolism. PPARalpha also functions to control inflammatory responses by repressing the activity of nuclear factor kappaB (NF-kappaB ...
Baranzini, Sergio E, Crowell, Andrea, Dunn, Shannon E, Loh, John, Oksenberg, Jorge, Ousman, Shalina S, Sobel, Raymond A, Steinman, Lawrence, Youssef, Sawsan, Zuniga, Luis   +9 more
core  

Neural precursor cells derived from induced pluripotent stem cells exhibit reduced susceptibility to infection with a neurotropic coronavirus. [PDF]

, 2017
The present study examines the susceptibility of mouse induced pluripotent stem cell-derived neural precursor cells (iPSC-NPCs) to infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV).
Lane, Thomas E, Mangale, Vrushali, Marro, Brett S, Plaisted, Warren C, Walsh, Craig M   +4 more
core   +1 more source

Type I interferon signalling and interferon‐responsive microglia in health and disease

The FEBS Journal, EarlyView.
Recent insights reveal that type I interferon (IFN‐I) signalling plays critical roles in the nervous system beyond antiviral defence. Dysregulated IFN‐I activity is increasingly linked to neurological dysfunction and neurodegeneration, with microglia as central mediators. This review explores the broader impact of IFN‐I signalling on the nervous system
Jose P. Lopez‐Atalaya, Aysha M. Bhojwani‐Cabrera   +1 more
wiley   +1 more source