Results 11 to 20 of about 13,969 (210)

Role of FAAH-like anandamide transporter in anandamide inactivation.

PLoS ONE, 2013
The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase
Kwannok Leung, Matthew W Elmes, Sherrye T Glaser, Dale G Deutsch, Martin Kaczocha   +4 more
doaj   +4 more sources

FAAH selectively influences placebo effects [PDF]

Molecular Psychiatry, 2013
Endogenous opioid and cannabinoid systems are thought to act synergistically regulating antinociceptive and reward mechanisms. To further understand the human implications of the interaction between these two systems, we investigated the role of the common, functional missense variant Pro129Thr of the gene coding fatty acid amide hydrolase (FAAH), the ...
Peciña, M., Martínez-Jauand, M., Hodgkinson, C., Stohler, C.S., Goldman, D., Zubieta, J.K.   +5 more
openaire   +2 more sources

Analgesic Effects of Fatty Acid Amide Hydrolase Inhibition in a Rat Model of Neuropathic Pain [PDF]

, 2006
Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states.
Barrett, David, Chapman, Victoria, Jhaveri, Maulik, Kendall, David, Richardson, Denise   +4 more
core   +4 more sources

Palmitoylethanolamide (PEA) regulates cell cycle progression and promotes an anti-inflammatory transcriptomic signature in C2C12 skeletal muscle cells. [PDF]

Physiol Rep
Abstract Palmitoylethanolamide (PEA) is an endogenous lipid mediator with immunomodulatory actions, yet its effects in skeletal muscle remain poorly defined. We examined whether PEA influences myogenesis and profiled the acute transcriptomic response of differentiated C2C12 myotubes to 10 μM PEA. PEA decreased myotube number (90.3 ± 10.6 vs. 112.6 ± 10.
Cole PL, Gillham SH, Viggars MR, Close GL, Owens DJ.   +4 more
europepmc   +2 more sources

MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer

Cell Death and Disease, 2023
Glycerophospholipid signal and fatty acid metabolism are closely related to the occurrence and progression of tumours, and metabolic reprogramming caused by hydrolytic enzymes plays an important role in gastric cancer (GC).
Qian Yang, Shan Kong, Jiajia Yu, Yanhua Xu, Mei Tao, Shuo Ma, Chenxue Tang, Xianjuan Shen, Zhiyuan Tang, Shaoqing Ju   +9 more
doaj   +1 more source

Lower amygdala fatty acid amide hydrolase in violent offenders with antisocial personality disorder: an [11C]CURB positron emission tomography study

Translational Psychiatry, 2021
Antisocial personality disorder (ASPD) imposes a high societal burden given the repetitive reactive aggression that affected individuals perpetrate. Since the brain endocannabinoid system (ECS) has been implicated in ASPD and aggressive behavior, we ...
Nathan J. Kolla, Isabelle Boileau, Karolina Karas, Jeremy J. Watts, Pablo Rusjan, Sylvain Houle, Romina Mizrahi   +6 more
doaj   +1 more source

FAAH inhibitors in the limelight, but regrettably [PDF]

Int. Journal of Clinical Pharmacology and Therapeutics, 2016
This short review focuses on the recent drug development of FAAH inhibitors, as recent serious adverse events have been reported in a phase I study with a compound of this class. The authors overview the potential interest in targeting FAAH inhibition, the current programs, and the available information on the recent dramatic events.
Mallet, Christophe, Dubray, Claude, Dualé, Christian   +2 more
openaire   +3 more sources

Unraveling Endocannabinoid Signaling Pathways in Cisplatin-Induced Ototoxicity. [PDF]

FASEB J
We performed a comprehensive molecular profiling of the endocannabinoid (eCB) system (ECS) in an auditory Hair cell (HC)‐like cell line (1). Afterwards, we developed suitable in vitro and in vivo models of cisplatin‐induced ototoxicity where we identified distinct components of the ECS (CB2R, DAGLβ and ABHD6) as molecular targets of the drug (2 ...
Palaniappan S, Tisi A, Di Meo C, Urbano C, Fenton GE, Della Valle F, Fanti F, Compagnone D, Nazarè M, Versnel H, Aramini A, Allegretti M, Maccarrone M.   +12 more
europepmc   +2 more sources

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

Journal of Lipid Research, 2005
N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH ...
Sachin Patel, Erica J. Carrier, W-S. Vanessa Ho, David J. Rademacher, Sonya Cunningham, D. Sudarshan Reddy, J.R. Falck, Benjamin F. Cravatt, Cecilia J. Hillard   +8 more
doaj   +1 more source

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source