Results 31 to 40 of about 13,969 (210)

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD in vitro

Reproduction and Fertility, 2021
Objective: To determine if models of human 'receptive' and 'non-receptive endometrium' differ in their responses to nitric oxide (NO) supplementation by measuring the levels of the enzymes of the endocannabinoid system (ECS) (fatty acid amide hydrolase ...
Sarah E Melford, Anthony H Taylor, Justin C Konje   +2 more
doaj   +1 more source

Expression and Function of the Endocannabinoid Modulating Enzymes Fatty Acid Amide Hydrolase and N-Acylphosphatidylethanolamine-Specific Phospholipase D in Endometrial Carcinoma

Frontiers in Oncology, 2019
Background: The concentrations of three N-acylethanolamines (NAEs), anandamide (AEA), N-oleoylethanolamide (OEA), and N-palmitylethanolamide (PEA) are increased in the endometria of women with endometrial cancer (EC).
Thangesweran Ayakannu, Thangesweran Ayakannu, Anthony H. Taylor, Anthony H. Taylor, Monica Bari, Nicoletta Mastrangelo, Mauro Maccarrone, Justin C. Konje, Justin C. Konje, Justin C. Konje   +9 more
doaj   +1 more source

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women [PDF]

, 2010
N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake.
Balvers, M.G.J., Hendriks, H.F.J., Joosten, M.M., Verhoeckx, K.C.M., Witkamp, R.F.   +4 more
core   +2 more sources

Polyunsaturated fatty acid-derived lipid mediators and T cell function [PDF]

, 2014
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open- access article distributed under the terms of the Creative Commons Attribution License (CC BY) .
Marelli-Berg, F, Mauro, C, Nicolaou, A, Urquhart, P   +3 more
core   +3 more sources

The influence of FAAH genetic variation on physiological, cognitive, and neural signatures of fear acquisition and extinction learning in women with PTSD

NeuroImage: Clinical, 2022
Background: Posttraumatic Stress Disorder (PTSD) is commonly treated with exposure-based cognitive therapies that are based on the principles of fear acquisition and extinction learning. Elevations in one of the major endocannabinoids (anandamide) either
Kevin M. Crombie, Anthony A. Privratsky, Chloe M. Schomaker, Mickela Heilicher, Marisa C. Ross, Anneliis Sartin-Tarm, Kyrie Sellnow, Elisabeth B. Binder, G. Andrew James, Josh M. Cisler   +9 more
doaj   +1 more source

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. [PDF]

, 2007
Recent studies have uncovered important cross talk between inflammation, generation of reactive oxygen and nitrogen species, and lipid metabolism in the pathogenesis of cardiovascular aging.
Bátkai, S., Cravatt, B.F., Csiszár, A., Haskó, G., Liaudet, L., Mukhopadhyay, P., Pacher, P., Rajesh, M., Ungvári, Z.   +8 more
core   +1 more source

Design of On-Target FAAH Inhibitors [PDF]

Chemistry & Biology, 2005
In this issue of Chemistry & Biology, Alexander and Cravatt propose a model for the binding of carbamate inhibitors to fatty acid amide hydrolase (FAAH), the enzyme that breaks down signaling lipids. Using competitive activity-based protein profiling and click chemistry, they designed potent and selective FAAH inhibitors and characterized their off ...
openaire   +2 more sources

The endocannabinoid hydrolase FAAH is an allosteric enzyme [PDF]

Scientific Reports, 2020
AbstractFatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that in vivo controls content and biological activity of N-arachidonoylethanolamine (AEA) and other relevant bioactive lipids termed endocannabinoids. Parallel orientation of FAAH monomers likely allows both subunits to simultaneously recruit and cleave substrates.
Dainese E., Oddi S., Simonetti M., Sabatucci A., Angelucci C. B., Ballone A., Dufrusine B., Fezza F., De Fabritiis G., Maccarrone M.   +9 more
openaire   +7 more sources

Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies. [PDF]

, 2013
Second-generation antipsychotic exposure, in both children and adults, carries significant risk for excessive weight gain that varies widely across individuals.
Aman, MG, Arnold, LE, Handen, B, Johnson, C, Lecavalier, L, McCracken, JT, McDougle, CJ, Nurmi, EL, Posey, DJ, Research Units on Pediatric Psychopharmacology Autism Network, Ritz, L, Scahill, LL, Spilman, SL, Stigler, KA, Sukhodolsky, DG, Tierney, E, Vitiello, B, Whelan, F   +17 more
core   +1 more source