Results 41 to 50 of about 13,969 (210)
PLoS ONE, 2015 BackgroundCombined fatty acid amide hydrolase (FAAH) and cyclooxygenase (COX) inhibition is a promising approach for pain-relief. The Flu-AM1 and Ibu-AM5 derivatives of flurbiprofen and ibuprofen retain similar COX-inhibitory properties and are more ...
Jessica Karlsson +11 more
doaj +1 more source
Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia. [PDF]
FASEB JTDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Mir HD +9 more
europepmc +2 more sources
Genetically reduced FAAH activity may be a risk for the development of anxiety and depression in persons with repetitive childhood trauma [PDF]
, 2016 Fatty acid amide hydrolase (FAAH) inhibitors are addressed for promising anxiolytics, but human studies on genetically reduced FAAH activity, stress and affective phenotypes are scarce.
Bagdy, György +3 more
core +1 more source
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S]
Journal of Lipid Research, 2011 Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs).
Jonathan Z. Long +3 more
doaj +1 more source
Neurobiology of Stress, 2021 The endocannabinoid system is involved in the regulation of the stress response, but the relative contribution of N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG) and their mechanisms have to be elucidated.
Francisco Javier Pavón +8 more
doaj +1 more source
2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals [PDF]
, 2017 Alzheimer´s disease (AD) is the most prevalent disorder of senile dementia mainly characterized by amyloid-beta peptide (Aβ) deposits in the brain. Cannabinoids are relevant to AD as they exert several beneficial effects in many models of this disease ...
Gaveglio, Virginia Lucía +3 more
core +1 more source
Crystals, 2019 Fatty acid amide hydrolase (FAAH) is a well-characterized member of the amidase signature (AS) family of serine hydrolases. The membrane-bound FAAH protein is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and ...
Cho-Ah Min +6 more
doaj +1 more source
Plant Direct, 2022 Fatty acid amide hydrolase (FAAH) is a conserved amidase that is known to modulate the levels of endogenous N‐acylethanolamines (NAEs) in both plants and animals.
Omar Arias‐Gaguancela +3 more
doaj +1 more source
Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. [PDF]
, 2016 Premutation carriers have a 55-200 CGG expansion in the fragile X mental retardation 1 (FMR1) gene. Currently, 1.5 million individuals are affected in the United States, and carriers are at risk of developing the late-onset neurodegenerative disorder ...
Giulivi, Cecilia +4 more
core +2 more sources
Role of cannabinoids in gastrointestinal mucosal defense and inflammation. [PDF]
, 2016 Modulating the activity of the endocannabinoid system influences various gastrointestinal physiological and pathophysiological processes, and cannabinoid receptors as well as regulatory enzymes responsible for the synthesis or degradation of ...
Gyires Klára, Zádori Zoltán Sándor
core +2 more sources