Results 81 to 90 of about 1,408,273 (290)

Heat shock proteins in tendinopathy: novel molecular regulators [PDF]

, 2012
Tendon disorders-tendinopathies-are the primary reason for musculoskeletal consultation in primary care and account for up to 30% of rheumatological consultations.
Neal L. Millar, George A. C. Murrell, Millar, N.L., Murrell, G.A.C.   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Complement Factor H: solution structures and interactions with ligands [PDF]

, 2009
Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core  

Complement factor H family proteins in their non-canonical role as modulators of cellular functions [PDF]

, 2019
Complement factor H is a major regulator of the alternative pathway of the complement system. The factor H-related proteins are less characterized, but recent data indicate that they rather promote complement activation.
Noémi Sándor, Éva Kárpáti, Kárpáti, Éva, Józsi, Mihály, Sándor, Noémi, Schneider, Andrea E., Mihály Józsi, Andrea E. Schneider   +7 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A role for sigma factor ?(E) in Corynebacterium pseudotuberculosis resistance to nitric oxide/peroxide stress [PDF]

, 2012
Pathogenic intracellular bacteria can respond to antimicrobial mechanisms of the host cell through transient activation of stress-responsive genes by alternative sigma (?) factors of the RNA polymerase.
Scrivens, James H., Sergio C. Oliveira, Vasco Azevedo, Scrivens, James, Carvalho, Natália B., Feelisch, Martin, Rodrigo D. Carvalho, Miyoshi, Anderson, Martin Feelisch, Meyer, Roberto, Thiago L. P. Castro, James H. Scrivens, Anderson Miyoshi, Luis G. C. Pacheco, Anderson eMiyoshi, Roberto eMeyer, Dorella, Fernanda A., Moraes, Pablo M., Pablo M. Moraes, Pacheco, Luis G.C., Castro, Thiago L.P., Carvalho, Rodrigo D., Azevedo, Vasco, Vasco A. C. Azevedo, Dowson, Christopher G., Natalia B. Carvalho, Martin eFeelisch, Oliveira, Sergio C., Carvalho, Rodrigo D. O., Christopher G. Dowson, Slade, Susan E., Castro, Thiago L. P., Fernanda A. Dorella, Pacheco, Luis G. C., James H Scrivens, Roberto Meyer, Susan E. Slade, Dowson, Christopher G   +37 more
core   +1 more source

Quantitative Proteomics Analysis of Ischemia/Reperfusion Injury-Modulated Proteins in Cardiac Microvascular Endothelial Cells and the Protective Role of Tongxinluo

Cellular Physiology and Biochemistry, 2017
Background: The protection of endothelial cells (ECs) against reperfusion injury has received little attention. In this study, we used Tandem Mass Tag (TMT) labeling proteomics to investigate the modulated proteins in an in vitro model of cardiac ...
Qing Li, He-He Cui, Yue-Jin Yang, Xiang-Dong Li, Gui-Hao Chen, Xia-Qiu Tian, Chen Jin, Qiu-Ting Dong, Pei-Sen Huang, Jun Xu   +9 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human

BMC Research Notes, 2009
Background Borreliae employ multiple immune evasive strategies such as binding to complement regulatory proteins [factor H (fH) and factor H like-1 (FHL1)], differential regulation of surface membrane proteins, antigenic variation, and binding of ...
Gil Horacio, Camafeita Emilio, Escudero Raquel, Bhide Mangesh R, Jado Isabel, Anda Pedro   +5 more
doaj   +1 more source