Results 91 to 100 of about 16,055,310 (231)

Interpretable Machine Learning Framework for Nb─Si Based Alloy Design with Enhanced Fracture Toughness

Advanced Science, EarlyView.
An interpretable machine learning framework integrating SHAP and PDP analysis identifies critical design descriptors from 139 physicochemical features for Nb─Si alloys. The framework achieves <7% prediction error and guides the discovery of Nb38.5Ti38.5Si3Zr18V2 alloy with 22.791 MPa·m1/2 fracture toughness, breaking the 20 MPa·m1/2 barrier.
Dezhi Chen, Chao Xu, Jingyue Yu, Qi Wang, Hongze Fang, Shuo Yin, Turab Lookman, Ruirun Chen   +7 more
wiley   +1 more source

COMPLEMENT REGULATOR FHR-3 IS ELEVATED EITHER LOCALLY OR SYSTEMICALLY IN A SELECTION OF AUTOIMMUNE DISEASES

Frontiers in Immunology, 2016
The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of hemolytic uremic syndrome (aHUS), whilst also found to be protective ...
Nicole Schäfer, Antje Grosche, Joerg Reinders, Stefanie Hauck, Richard B. Pouw, Taco W. Kuijpers, Taco W. Kuijpers, Diana Wouters, Boris Ehrenstein, Volker Enzmann, Peter Zipfel, Peter Zipfel, Christine Skerka, Diana Pauly   +13 more
doaj   +1 more source

P. pneumotropica binds to Factor H and regulates the alternative complement pathway.

, 2014
(A) P. pneumotropica suspensions (108 bacteria/tube) were incubated with 1 µg of human Factor H (FH) for 2 h or normal human serum (NHS) for 30 min.
Tatiana Rodrigues Fraga (649486), Alfredo Sahagún-Ruiz (649483), Angela Silva Barbosa (649488), Lourdes Isaac (373116), Leandro Carvalho Dantas Breda (649485), Mónica Marcela Castiblanco Valencia (649487), Adriana Patricia Granados Martinez (649484)   +6 more
core   +1 more source

An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy. [PDF]

, 2015
Abnormal regulation of the complement alternative pathway is associated with C3 glomerulopathy. Complement factor H is the main plasma regulator of the alternative pathway and consists of 20 short consensus repeat (SCR) domains. Although recombinant full-
Thomas D. Barbour, Edwin K.S. Wong, Jeremy M. Palmer, Wong, EK, Pickering, MC, Palmer, JM, Pappworth, IY, Isabel Y. Pappworth, Barbour, TD, Kevin J. Marchbank, Eva-Maria Nichols, Sheerin, NS, Marchbank, KJ, Nichols, EM, Matthew C. Pickering, Neil S. Sheerin   +15 more
core   +1 more source

Strategy of Triple‐Gradient in Binary Pixels for Flexible Pressure Sensing with High Sensitivity and Wide‐Range Linearity

Advanced Science, EarlyView.
A flexible pressure sensor with triple‐gradient design of conductivity, modulus, and dimension in binary micro‐dome pixels is proposed. Based on precisely‐designed CNT/PDMS matrix, the device exhibits a linear sensitivity of 974.1 kPa−1 across range up to 1.8 MPa (R2 > 0.99), offering an effective strategy for potential applications in healthcare ...
Yifan Liu, Xiao Xu, Fengming Hu, Yuanzhe Liang, Zidong Yin, Biao Qi, Ruolin Liu, Ziyi Dai, Jianyi Luo, Bingpu Zhou   +9 more
wiley   +1 more source

The specific contributions of factor H and factor I in controlling fluid phase activation of the alternative complement pathway

Scientific Reports
The immediate defense provided by the alternative complement pathway (AP) is under constant control by fluid phase regulators, factor H (FH) and factor I (FI), to prevent nonessential activation.
Nancy A. Turner, Joel L. Moake
doaj   +1 more source

Complement regulator factor H in multiple sclerosis

, 2011
A recent proteomic study published in this journal demonstrated lower cerebrospinal fluid (CSF) expression of factor H (fH), an important complement regulator, along with two other complement proteins, in active multiple sclerosis (MS) patients.
Morgan, Bryan Paul, Samantha Loveless, Robertson, Neil, B. Paul Morgan, Ingram, Gillian, Loveless, Samantha, Neil Robertson, Svetlana Hakobyan, Hakobyan, Svetlana, Gillian Ingram   +9 more
core   +1 more source

Voltage‐Reconfigurable Magneto‐Ionic Nanolayers in Dot Arrays for Probabilistic, Materials‐Engineered Security Primitives

Advanced Science, EarlyView.
A magneto‐ionic security‐by‐materials‐design strategy exploits voltage‐driven N3– migration in selectively contacted FeCoN dots, creating reconfigurable sub‐15 nm ferromagnetic sublayers with deterministic and/or probabilistic (single‐domain↔vortex) states, voltage‐tunable probabilities and fully stochastic orientation/chirality.
Irena Spasojevic, Federica Celegato, Alessandro Magni, Paola Tiberto, Jordi Sort   +4 more
wiley   +1 more source

Toward High‐Resolution Polymeric Neural Interfaces: A Practical Guide for Electron Beam Lithography

Advanced Science, EarlyView.
Electron beam lithography (EBL) enables sub‐micron patterning of polymer‐based neural implants, overcoming the resolution limits of optical lithography. By addressing challenges such as charging, non‐planarity, and substrate heating, it supports higher channel density, improved miniaturization, and better long‐term tissue integration.
Hanna Karlsson‐Fernberg, Maria Asplund
wiley   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source