Results 131 to 140 of about 16,055,310 (231)

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Glycosaminoglycan-protein interactions and human complement factor H [PDF]

, 2010
Glycosaminoglycans (GAGs) are linear polysaccharides expressed ubiquitously on animal cell surfaces and within extracellular matrices. GAGs usually occur as parts of proteoglycans and often accomplish their biological functions through their ...
Blaum, Bärbel
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Stretchable h‐BN/TPU Fibers for Passive‐Active Dual‐Mode Thermal Management and Wearable Haptic Interfaces

Advanced Science, EarlyView.
Optimized 30 wt.% h‐BN/TPU fibers create a thermal conductivity of 2.08 W·m−1·K−1 while retaining mechanical compliance (422% elongation at break). Woven fabrics reduce surface temperature by 5.7°C under simulated solar irradiation. Glove integration enables localized fingertip heating at 29.55°C·s−1 with a thermal relaxation time of approximately 20 s.
Yiwei Zhou, Shanshan Long, Bo Chen, Maohua Li, Linhong Li, Yue Qin, Rongjie Yang, Hanxi Chen, Cheng‐Te Lin, Yixiang Xu, Kean How Cheah, Nan Jiang, Jinhong Yu   +12 more
wiley   +1 more source

TGF-β specifies T_FH versus T_H17 cell fates in murine CD4⁺ T cells through c-Maf

T follicular helper (T-FH) cells are essential for effective antibody responses, but deciphering the intrinsic wiring of mouse T-FH cells has long been hampered by the lack of a reliable protocol for their generation in vitro. We report that transforming
Kallies, A., Jost, P., Meissner, F., Chang, Y., Paeschke, K., Abdullah, Z., Ohnmacht, C., Baumjohann, D., Gutierrez-Melo, N., Beyer, M., Alterauge, D., Hasenauer, J., Burton, O., Bach, L., van Uelft, M., Becker, M., Tsui, C., Reschke, S., Becker, J., Raj, T., Steffen, T., Heissmeyer, V., Heink, S., Kastl, M., Utzschneider, D., Wen, L., Symeonidis, K., Hasiuk, M., Neumann, C., Zeitraeg, J., Elmzzahi, T., Krebs, S., Blum, H., Korn, T., Liston, A., Cheng, J., Dahlstroem, F., Jeker, L.   +37 more
core   +1 more source

Improved Skills for Predicting Sub‐Seasonal to Seasonal Global Sea Surface Temperature

Advanced Science, EarlyView.
Addressing the critical Sub‐seasonal to Seasonal predictability gap, this study presents CAS‐Canglong, a novel deep learning framework. By leveraging 3D Swin‐Transformers to capture long‐range ocean interactions, the model demonstrates superior skill over traditional GCMs.
Longhao Wang, Xuanze Zhang, Ruby L. Leung, Francis H. S. Chiew, Amir AghaKouchak, Kairan Ying, Yongqiang Zhang   +6 more
wiley   +1 more source

Thioredoxin‐2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation

Advanced Science, EarlyView.
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Chi Zhan, Zhaocai Zhou, Yue Ding, Rong Lian, Xinyu Li, Xintong Zhang, Jie Cao, Zhonghui Tang, Zhengmei Lin, Zhi Song, Feng He   +10 more
wiley   +1 more source

Evaluierung offener Lernszenarien : Tagungsband zum 13. E-Learning-Tag der FH Joanneum am 17.9.2014

, 2014
ZML - Innovative Lernszenarien (FH Joanneum); Herausgeberin: Jutta PauschenweinErhältlich unter: jutta.pauschenwein@fh-joanneum.atEnthält LiteraturangabenBeiträge teilweise deutsch, teilweise ...
E-Learning Tag 13. 2014 Graz
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Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

HECTD1 Directs HIF‐1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis

Advanced Science, EarlyView.
HECTD1 emerges as an upstream amplifier of Th17 metabolic programming by promoting K63‐linked ubiquitination of IGF2BP3 and enhancing HIF‐1α translation. HIF‐1α reciprocally drives HECTD1 transcription, establishing a positive regulatory loop that sustains glycolysis and Th17 differentiation.
Shuiyu Xu, Qiaoqiao Han, Feixiang Wang, Yuerong Zhang, Haoran Feng, Kun Liu, Fang Xiu Luo, Fei Yuan, Xuesong Zhao, Xiaoyan Yu, Haiyan Huang, Qiang Zou, Ren Zhao   +12 more
wiley   +1 more source

Atypical hemolytic uremic syndrome and mutation analysis of factor H gene in two Tunisian families

, 2010
Imen Habibi1,Imen Sfar1,Walid Ben Alaya1, Jihen Methlouthi2, Abdelkrim Ayadi2, Mounira Brahim2, Jacques Blouin3, Raoudha Dhagbouj1, Thouraya Ben Rhomdhane1, Mouna Makhlouf1, Houda Aouadi1, Saloua Ayed-Jendoubi1, Véronique Fremeaux-bacchi3 ...
et al, Walid Ben Alaya, Imen Habibi, Imen Sfar   +3 more
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