Results 1 to 10 of about 242,574 (165)
Anticoagulation by factor Xa inhibitors [PDF]
Journal of Thrombosis and Haemostasis, 2010 Therapeutic agents that regulate blood coagulation are critical to the management of thrombotic disorders, with the selective targeting of factor (F) Xa emerging as a promising approach.To assess anticoagulant strategies targeting FXa.A deterministic computational model of tissue factor (Tf)-initiated thrombin generation and two empirical experimental ...
Thomas Orfeo +4 more
openaire +3 more sources
Establishment of prophylactic enoxaparin dosing recommendations to achieve targeted anti-factor Xa concentrations in children with CHD [PDF]
, 2018 Background Enoxaparin may be used to prevent central venous catheter-related thrombosis in patients with CHD. We aimed to determine whether current enoxaparin dosing regimens effectively achieve anti-factor Xa concentrations within prophylactic goal ...
Israel, Emily N. +2 more
core +1 more source
Factor Xa or thrombin: is factor Xa a better target? [PDF]
Journal of Thrombosis and Haemostasis, 2007 Existing vitamin K antagonists (VKAs) have drawbacks that limit their effectiveness, safety, and overall frequency of use. Oral anticoagulants in development with targeted action against individual coagulation factors, specifically direct factor (F) Xa and IIa inhibitors, appear to have pharmacokinetic and pharmacodynamic properties that overcome the ...
openaire +2 more sources
The spatial temporal regime of stream flow of the conterminous U.S. in connection with indices of global atmospheric circulation [PDF]
, 2007 Long-term stream flow records (1929-1988) from seventy one U.S. Geological Survey gauging stations with drainage area in range 1000-10000 sq mi were analyzed using multivariate statistics. Factor analysis of average annual flow revealed seven patterns of
Boris Shmagin +2 more
core +2 more sources
Multidimensional Analysis of Snow Cover Data in South Dakota Diversity of Landscapes [PDF]
, 2008 Snow distribution in SD was studied with Factor Analysis (FA) of monthly total snowfall [in]. The long-term data obtained from the High Plains Regional Climate Center were used for the territory of South Dakota.
Boris Shmagin, Carol Johnston
core +2 more sources
Roles of factor Xa beyond coagulation [PDF]
Journal of Thrombosis and Thrombolysis, 2021 AbstractOral anticoagulant therapy has changed by clinical evidence that coagulation factor Xa (FXa) can be safely and effectively targeted for thromboprophylaxis. Because thrombotic and thrombo-inflammatory diseases are frequently caused by excessive activation of the tissue factor (TF) pathway, activation of FX by the TF-FVIIa complex is of central ...
openaire +4 more sources
, 2016 Factor Xa represents an attractive target for antithrombotic drugs as blockade of factor Xa permits inhibition of both the extrinsic and intrinsic coagulation pathways. Several factor Xa inhibitors, such as rivaroxaban, apixaban and edoxaban, have been approved for certain conditions, and are also in clinical development for other indications.
Gregory Y.H. Lip, Eduard Shantsila
openaire +2 more sources
The eDAL Suite: Tools and Concepts for Primary Data Citation [PDF]
, 2010 Retrieval and citation of primary data is the important factor in the approaching age of “data science”. Digital data are easily shared, and just as easily wiped or lost.
Christian Colmsee +6 more
core +2 more sources
Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors [PDF]
, 2001 Background: A major current focus of pharmaceutical research is the development of selective inhibitors of the blood coagulation enzymes thrombin or factor Xa to be used as orally bioavailable anticoagulant drugs in thromboembolic disorders and in the ...
Bauer, Margit +8 more
core +1 more source
Thrombogenicity of small-diameter prosthetic grafts: Relative contributions of graft-associated thrombin and factor Xa [PDF]
, 1997 Purpose:We evaluated the contributions of coagulation factors IIa (thrombin) and Xa to small-diameter prosthetic graft thrombogenicity in vivo.Methods:Preclotted and nonpreclotted (collagen-coated) polyester grafts were studied before and 24 hours after ...
Abendschein, Dana R. +3 more
core +1 more source