Results 41 to 50 of about 12,986,553 (373)
TH Open, 2018 Rivaroxaban and apixaban are both small molecules that reversibly inhibit factor Xa. Compared with rivaroxaban, apixaban has minimal effects on the prothrombin time and activated partial thromboplastin time.
Paul Y. Kim +7 more
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Heavy menstrual bleeding on direct factor Xa inhibitors: Rationale and design of the MEDEA study
Research and Practice in Thrombosis and Haemostasis, 2021 Background In premenopausal women, treatment with direct oral factor Xa inhibitors is associated with an increased risk of heavy menstrual bleeding (HMB) compared with vitamin K antagonists (VKA).
Eva N. Hamulyák +18 more
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Discovery and development of Factor Xa inhibitors (2015–2022)
Frontiers in Pharmacology, 2023 As a pathological coagulation process, thrombus can lead to many serious diseases, including ischemic stroke, acute myocardial infarction (AMI), acute coronary syndrome (ACS), and deep venous thrombosis (DVT).
Wei Zheng +5 more
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Anticoagulation by factor Xa inhibitors [PDF]
Journal of Thrombosis and Haemostasis, 2010 Therapeutic agents that regulate blood coagulation are critical to the management of thrombotic disorders, with the selective targeting of factor (F) Xa emerging as a promising approach.To assess anticoagulant strategies targeting FXa.A deterministic computational model of tissue factor (Tf)-initiated thrombin generation and two empirical experimental ...
T, Orfeo +4 more
openaire +2 more sources
Blood Advances, 2019 A targeted antidote for reversal of direct factor Xa (FXa) inhibitors is now available for clinical use in the United States, but it is costly and has limited availability.
Siavash Piran +8 more
semanticscholar +1 more source
Multidimensional Analysis of Snow Cover Data in South Dakota Diversity of Landscapes [PDF]
, 2008 Snow distribution in SD was studied with Factor Analysis (FA) of monthly total snowfall [in]. The long-term data obtained from the High Plains Regional Climate Center were used for the territory of South Dakota.
Boris Shmagin, Carol Johnston
core +2 more sources
eNeurologicalSci, 2022 Long-term anticoagulation in the treatment of Cerebral Venous Sinus Thrombosis (CVST) has revolved around the use of warfarin. The relatively recent introduction of Direct Oral Anticoagulants (DOACs), such as Factor Xa inhibitors, in treating CVSTs ...
Alexei Christodoulides +1 more
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Azadirachta indica induced suppression of Mycobacterium tuberculosis secreted proteins in human monocyte [PDF]
, 2008 The H37Rv strain of MTB was grown in modified Sauton’s medium till mid-log phase. Peripheral blood mononuclear cells (PBMC) were isolated by density gradient sedimentation on Ficoll-Paque separation medium.
Ajay Kumar, Jawed Iqbal, Najmul Islam
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Clinical and Applied Thrombosis/Hemostasis, 2020 Identifying the cause of a bleeding complication after cardiac surgery can be crucial. This study sought to clarify whether the application of unprocessed autologous pump blood influences anti-factor Xa activity after cardiac surgery and evaluated 2 ...
Saskia Wand MD +6 more
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Molecules, 2016 The geometries and energies of factor Xa inhibitors edoxaban, eribaxaban, fidexaban, darexaban, letaxaban, and the dual factor Xa and thrombin inhibitors tanogitran and SAR107375 in both the gas-phase and aqueous solution were studied using the Becke3LYP/
Milan Remko, Anna Remková, Ria Broer
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