Results 61 to 70 of about 242,673 (264)

Synthesis of Nucleoside Derivatives by Biomimetic Ester Migration

ChemBioChem, Accepted Article.
Modified nucleosides play important roles as agents in medicinal chemistry due to their anti‐inflammatory, antiviral and anti‐proliferative properties, as well as in biochemical processes like protein biosynthesis. Aminoacylated nucleosides in tRNA represent the central transfer unit of amino acids in the biosynthesis of peptides.
Oliver Trapp, Nathalie J. Kurrle, Christoph J. B. Seifert, Nathalie Hampel, Tamara Rauch, Michael Thoma, Luca V. Parziale, Marian S. R. Ebeling, Dino Berthold   +8 more
wiley   +1 more source

Epidemiological landscape of Batrachochytrium dendrobatidis and its impact on amphibian diversity at global scale

Wildlife Biology, EarlyView., 2023
Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), is a major driver of amphibian decline worldwide. The global presence of Bd is driven by a synergy of factors, such as climate, species life history, and amphibian host susceptibility.
M. Delia Basanta, Julián A. Velasco, Constantino González‐Salazar   +2 more
wiley   +1 more source

Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian [PDF]

, 2009
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China.
Fuhou Chang, Guang Wang, Jia Ma, Jun QI, Min-jie Wang, Qin Yin, Zhi-Xie Zhang   +6 more
core   +1 more source

Increased Thrombogenicity is Associated With Coronary Microvascular Dysfunction in Patients With STEMI—A Proof‐of‐Concept Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Up to 50% of patients with ST‐segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) develop coronary microvascular dysfunction (CMD). Aims This study aims to assess whether a prothrombotic state of coronary blood, defined by thromboelastography (TEG), is associated with post ...
Roberto Scarsini, Denis Leonardi, Andrea Bottardi, Concetta Mammone, Leonardo Portolan, Caterina Butturini, Verdiana Galli, Francesco Della Mora, Alessandro Ruzzarin, Sara Pazzi, Anna Piccoli, Simone Fezzi, Domenico Tavella, Gabriele Pesarini, Leonardo Gottin, Flavio Ribichini   +15 more
wiley   +1 more source

Role of Factor Xa Inhibitors in Cancer-Associated Thrombosis: Any New Data? [PDF]

, 2011
The association between cancer and venous thromboembolism (VTE) has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative.
Afshar-Kharghan, Vahid, Escalante, Carmen, Kroll, Michael H., Yusuf, Syed Wamique, Zalpour, Ali   +4 more
core   +3 more sources

Enhancing B/N‐H Fuel Cell Durability: Insights from Degradation Mechanisms and Optimization

ChemElectroChem, EarlyView.
This study investigates durability challenges in direct liquid fuel cells using B/N‐H fuels (decaborane and hydrazine borane). Initial tests revealed rapid degradation (81.6% and 46.4% losses) due to electrode instability and product buildup. Optimizations (gas diffusion layer, ionomer/carbon ratio, and ion exchange membrane) significantly enhanced ...
Peng Qiu, Yang Zhang, Qiqi Wan, Endao Zhang, Wenxing Jiang, Zhenying Chen, Xiaodong Zhuang, Lijun Zhang, Changchun Ke   +8 more
wiley   +1 more source

Recycling spent synthesis liquor for enhanced production of ZIF‐67: Characterization and morphological insights

ChemNanoMat, Accepted Article.
This study reports the preparation and characterization of ZIF‐67 through the recycling of spent synthesis liquor containing unreacted 2‐methylimidazole. Materials were characterized using XRD, SEM, N2 physisorption, and SAXS. The recycling enhanced the yield of ZIF‐67 while maintaining the dodecahedral rhombic morphology of the particles. In the first
Lucas Leocadio Battiston, Barbara Gerbelli, Fabiano Yokaichiya, Ivan Ricardo Barros, Kátia Dionísio Oliveira, Cícero Naves Ávila-Neto   +5 more
wiley   +1 more source

XANTUS: rationale and design of a noninterventional study of rivaroxaban for the prevention of stroke in patients with atrial fibrillation. [PDF]

, 2014
Atrial fibrillation (AF) is associated with a fivefold increase in the risk of stroke. The Phase III ROCKET AF (Rivaroxaban Once-Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in ...
Amarenco, P, Camm, AJ, Haas, S, Hess, S, Kirchhof, P, Turpie, AG, van Eickels, M   +6 more
core   +2 more sources

Modeling and Simulation to Inform Apixaban Dosing in Pediatrics With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma Treated With Asparaginase

Clinical Pharmacology &Therapeutics, EarlyView.
Apixaban could be a potential treatment option for the prevention of venous thromboembolism (VTE) in children with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma (LL). This analysis describes an updated two‐compartment population pharmacokinetic (PPK) model that characterizes the PK variability of apixaban in pediatric patients with ALL ...
Praneeth Jarugula, Toni Ajavon‐Hartmann, Obinna Obianom, Elizabeth Ludwig, Christina Crevar, David Marchisin, Zhaoqing Wang, Weidong Chen, Bing He, Lesley G. Mitchell, Vilmarie Rodriguez, Glen Lew, Vidya Perera, Bindu Murthy, Samira Merali   +14 more
wiley   +1 more source

Impact of Age and Factor Xa Inhibitor Concentrations on Bleeding Risk in Patients with Atrial Fibrillation

Clinical Pharmacology &Therapeutics, EarlyView.
This study aimed to analyze differences in the exposure‐response relationship for factor Xa inhibitors (FXaI) between patients aged ≥ 80 and < 80 years. Patients with atrial fibrillation (AF) taking rivaroxaban, apixaban, or edoxaban were enrolled, and a single steady‐state trough concentration was measured.
Shin‐Yi Lin, Yen‐Bing Liu, Li‐Ting Ho, Ching‐Hua Kuo, Yu‐Fong Peng, Chih‐Fen Huang, Sung‐Chun Tang, Jiann‐Shing Jeng   +7 more
wiley   +1 more source