Results 71 to 80 of about 2,920,145 (314)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Faculty Members’ Promotion: Challenges and Solutions [PDF]

open access: yesStrides in Development of Medical Education, 2021
Sara Shafian, Mahla Salajegheh
doaj   +1 more source

Docência no ensino médico: por que é tão difícil mudar?

open access: yesRevista Brasileira de Educação Médica
Apesar do reconhecimento da necessidade de mudanças no ensino médico, a prática docente tem-se mostrado resistente a modificações. Este trabalho de revisão identifica os fatores que limitam mudanças na prática docente em Medicina.
Nilce Maria da Silva Campos Costa
doaj   +1 more source

Discussing the Undiscussed: What Ingredients are Missing in Faculty Development Programs? [PDF]

open access: yesResearch and Development in Medical Education, 2018
Background: Faculty development programs are essential for the advancement of faculty competence and organizational vitality. This is a multidimensional, daunting task because it involves transforming early career faculty with newer professional ...
Dinesh Kumar
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Faculty Development Interventions in Medical Education During the COVID-19 Pandemic: A Systematic Review

open access: yesEducation Sciences
The onset of the COVID-19 pandemic in March 2020 began a series of disruptions that rapidly impacted medical education across the globe. This review collates current literature that relates to medical education faculties’ development interventions as a ...
Hengameh Karimi, Sarwar Khawaja
doaj   +1 more source

A model for faculty engagement in distributed medical education: Crafting a paddle

open access: yesCanadian Medical Education Journal, 2018
Distributed medical education initiatives are now a key component of all Canadian medical schools.  The success of these initiatives requires engaged community-based faculty who are able to successfully balance both their clinical and educational ...
Barbara Zelek, James Goertzen
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Home - About - Disclaimer - Privacy