Results 111 to 120 of about 22,623 (220)
Journal of Lipid Research, 2005 N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH ...
Sachin Patel +8 more
doaj +1 more source
Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014)
Expert Opinion on Therapeutic Patents, 2015 Fatty acid amide hydrolase (FAAH) is a key enzyme responsible for the degradation of the endocannabinoid anandamide. FAAH inactivation is emerging as a strategy to treat several CNS and peripheral diseases, including inflammation and pain. The search for effective FAAH inhibitors has thus become a key focus in present drug discovery.Patents and patent ...
LODOLA, Alessio +3 more
openaire +3 more sources
Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. [PDF]
, 2012 Facoltà di Farmacia Corso di laurea in Chimica e tecnologia farmaceutica; Relatore: prof.ssa C.Manera, dott.ssa F.Castelli; SSD: CHIM 08 Candidato: Gianfilippo Martello Titolo tesi: Design, synthesis and biological evaluation of heterocyclic derivatives ...
MARTELLO, GIANFILIPPO
core
Acta Pharmaceutica Sinica B, 2011 A predictive pharmacophore model has been generated from a series of diverse fatty acid amide hydrolase (FAAH) inhibitors and the optimal pharmacophore model applied in virtual screening.
Dong-sheng Zhao +4 more
doaj +1 more source
PLoS ONE, 2012 BackgroundWhile the etiology of depression is not clearly understood at the present time, this mental disorder is thought be a complex and multifactorial trait with important genetic and environmental contributing factors.Methodology/principal ...
K Yaragudri Vinod +5 more
doaj +1 more source
Targeting Fatty Acid Amide Hydrolase Counteracts the Epithelial-to-Mesenchymal Transition in Keratinocyte-Derived Tumors. [PDF]
Int J Mol Sci, 2023 Kovacs D +8 more
europepmc +1 more source
Endocannabinoid Involvement in Impulsivity and Decision-making [PDF]
, 2014 Problem gambling is a widespread phenomenon with a prevalence estimate of 2.3% globally (Williams, Volberg, & Stevens, 2012). Although little is known about the neurochemistry underlying this pathological behaviour, evidence suggests that dysregulation ...
Norris, Christopher P
core +1 more source
Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition. [PDF]
Sci Rep, 2023 Alegre-Zurano L +5 more
europepmc +1 more source