Results 11 to 20 of about 2,751,456 (226)

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

FADS Gene Cluster Polymorphisms: Important Modulators of Fatty Acid Levels and Their Impact on Atopic Diseases [PDF]

, 2009
Long-chain polyunsaturated fatty acids (LC-PUFAs) play an important role in several physiological processes and their concentration in phospholipids has been associated with several complex diseases, such as atopic disease.
Lattka, E., Lattka, Eva, Heinrich, Joachim, Illig, T., Koletzko, Berthold, Heinrich, J., Illig, Thomas, Koletzko, B.   +7 more
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Eicosapentaenoic acid and 3,10 dithia stearic acid inhibit the desaturation of trans-vaccenic acid into cis-9, trans-11-conjugated linoleic acid through different pathways in Caco-2 and T84 cells. [PDF]

, 2006
Stearoyl-CoA desaturase (SCD) is a key enzyme that determines the composition and metabolic fate of ingested fatty acids, in particular the conversion of trans-vaccenic acid (TVA) to conjugated linoleic acid (CLA).
Renaville, B, Mullen, Anne, Anne Mullen, Moloney, F, RENAVILLE, Benedicte France Ghislaine, MOLONEY F, LARONDELLE Y, Helen M. Roche, Molonay, Fiona, Roche, HM, Fiona Moloney, Yvan Larondelle, Mullen, A, Renaville Bénédicte, Moloney, Fiona, Larondelle, Yvan, Yves-Jacques Schneider, MULLEN A, SCHNEIDER YJ ROCHE HM, Roche, Hélèje M., Renaville, Bénédicte, Roche, Helen M, Larondelle, Y, Schneider, Yves-Jacques   +23 more
core   +1 more source

DES2 is a fatty acid Delta 11 desaturase capable of synthesizing palmitvaccenic acid in the arbuscular mycorrhizal fungus Rhizophagus irregularis [PDF]

, 2020
Arbuscular mycorrhizal (AM) fungi are oleaginous organisms, and the most abundant fatty acyl moiety usually found in their lipids is palmitvaccenic acid (16:1Δ11cis). However, it is not known how this uncommon fatty acid species is made.
Bhutada, G., Cheeld, H., Peter J. Eastmond, Frederic Beaudoin, Beaudoin, F., Henry Cheeld, Eastmond, P. J., Govindprasad Bhutada   +7 more
core   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Supplementation with n-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells [PDF]

, 2014
BACKGROUND: Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation ...
Burdge, Graham C., Mori, T.A., Karen A Lillycrop, Samuel P Hoile, Rebecca Clarke-Harris, Clarke-Harris, R., Graham C Burdge, Beilin, L.J., Philip C Calder, Lawrence J Beilin, Calder, P.C., Huang, R.C., Lillycrop, Karen A., Trevor A Mori, Hoile, Samuel P., Rae-Chi Huang   +15 more
core   +1 more source

Influence of FADS polymorphisms on tracking of serum glycerophospholipid fatty acid concentrations and percentage composition in children. [PDF]

, 2011
Tracking of fatty acid (FA) contribution to plasma or serum lipids over time was shown in children and adults. However, the potential role of FADS gene variants has not been investigated.
Demmelmair Hans, Berthold Koletzko, Rzehak, P., Claudia Glaser, Peter Rzehak, Joachim Heinrich, Heinrich, Joachim, Glaser, C., Glaser, Claudia, Heinrich, J., LISA study group, Klopp Norman, Demmelmair, Hans, Klopp, N., Rzehak, Peter, Demmelmair, H., Koletzko Berthold, Rzehak Peter, Glaser Claudia, LISAplus Study Group (Wichmann, H.-E. ; Heinrich, J. ; Bolte, G. ; Belcredi, P. ; Jacob, B. ; Schoetzau, A. ; Mosetter, M. ; Schindler, J. ; Höhnke, A.), Hans Demmelmair, null null, Norman Klopp, Heinrich Joachim, Koletzko, Berthold, Klopp, Norman, Koletzko, B., Glaser, C;Rzehak, P;Demmelmair, H;Klopp, N;Heinrich, J;Koletzko, B   +27 more
core   +1 more source

The Generation of Transgenic Mice with Fat1 and Fad2 Genes that have their own Polyunsaturated Fatty Acid Biosynthetic Pathway

Cellular Physiology and Biochemistry, 2013
Background: Microorganisms and higher plants possess their own omega-3 and omega-6 polyunsaturated fatty acid (PUFAs) biosynthetic pathways. The n-6 fatty acid desaturase gene fad-2 codes for the n-6 desaturase enzyme that coverts oleic acid (OA 18:1 n-9)
Yue Chen, Mei Mei, Peng Zhang, Kuiying Ma, Guangqi Song, Xin Ma, Tianchuang Zhao, Bo Tang, Hongsheng Ouyang, Guangpeng Li, Ziyi Li   +10 more
doaj   +1 more source