Results 11 to 20 of about 39,692 (272)

Membrane fatty acid desaturase: biosynthesis, mechanism, and architecture

Applied Microbiology and Biotechnology, 2022
Fatty acid desaturase catalyzes the desaturation reactions by inserting double bonds into the fatty acyl chain, producing unsaturated fatty acids, which play a vital part in the synthesis of polyunsaturated fatty acids.
Raja Abd Rahman, Raja Noor Zaliha, Thean, Adam Chor Leow, Abd Halim, Nur Farah Anis, Mohamad Ali, Mohd Shukuri   +3 more
core   +3 more sources

Fatty acid desaturases from the microalga Thalassiosira pseudonana [PDF]

The FEBS Journal, 2005
Analysis of a draft nuclear genome sequence of the diatom Thalassiosira pseudonana revealed the presence of 11 open reading frames showing significant similarity to functionally characterized fatty acid front-end desaturases.
Qing, R., Sayanova, O. V., Larson, T. R., Michaelson, L. V., Li, Y., Napier, J.A., Tonon, T., Graham, I. A., Sayanova, O., Michaelson, L.V., Graham, I.A., Napier, J. A., Larson, T.R., Harvey, D.   +13 more
core   +4 more sources

Chimeras of delta6-fatty acid and delta8-sphingolipid desaturases

Biochemical and biophysical research communications, 2000
The Borago officinalis Delta6 fatty acid desaturase (Boofd6) shares 58% identity in its amino acid sequence with Boofd8, a Delta8 sphingolipid desaturase from the same plant species.
Michaelson, L. V., Lewis, M. J., Libisch, B., Napier, J. A., Shewry, P. R.   +4 more
core   +3 more sources

Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances [PDF]

Nutrients, 2016
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human health and development, and numerous fatty acid desaturases play key roles in synthesizing PUFAs. Given the lack of delta-12 and -15 desaturases and the low levels of conversion to PUFAs, humans must consume some omega-3 and omega-6 fatty acids in their diet ...
Je Lee, Hyungjae Lee, SeokBeom Kang, Woo Park   +3 more
openaire   +2 more sources

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Hepatology, EarlyView., 2022
Abstract Background and Aims There is an ongoing debate on whether NAFLD is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers   +4 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The role of fatty acid desaturases in epidermal metabolism [PDF]

Dermato-Endocrinology, 2011
The lipid composition of skin is important to a variety of functions served by this organ. Therefore, skin expresses multiple enzymes that synthesize and metabolize lipids. An important class of lipid metabolism enzymes expressed in skin is the lipid desaturases.
Sampath, Harini, Ntambi, James M
openaire   +2 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study

Lipids in Health and Disease, 2017
Background Visceral fat accumulation in overweight status has been resulted in changes of fatty acid profiles. The fatty acids profiles can be altered by fatty acid desaturase; the activity of which is highly associated with obesity and other metabolic ...
Miso Kang, Ayoung Lee, Hye Jin Yoo, Minjoo Kim, Minkyung Kim, Dong Yeob Shin, Jong Ho Lee   +6 more
doaj   +1 more source