Results 51 to 60 of about 39,692 (272)

A more desirable balanced polyunsaturated fatty acid composition achieved by heterologous expression of Δ15/Δ4 desaturases in mammalian cells.

PLoS ONE, 2013
Arachidonic (ARA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids are the most biologically active polyunsaturated fatty acids, but their biosyntheses in mammals are very limited.
Guiming Zhu, Qin Ou, Tao Zhang, Xudong Jiang, Guozhi Sun, Ning Zhang, Kunfu Wang, Heng Fang, Mingfu Wang, Jie Sun, Tangdong Ge   +10 more
doaj   +1 more source

Fatty Acid Profile and Desaturase Activity in Obesity: Roles, Mechanisms, and Clinical Relevance

Metabolites
Background: Obesity is a complex metabolic disease associated with several health complications, including insulin resistance, hypertension, and type 2 diabetes mellitus.
Michalina Banaszak, Ilona Górna, Sławomira Drzymała-Czyż   +2 more
doaj   +1 more source

Red Blood Cell Fatty Acids and Incident Diabetes Mellitus in the Women's Health Initiative Memory Study. [PDF]

PLoS ONE, 2016
CONTEXT:The relations between dietary and/or circulating levels of fatty acids and the development of type 2 diabetes is unclear. Protective associations with the marine omega-3 fatty acids and linoleic acid, and with a marker of fatty acid desaturase ...
William S Harris, Juhua Luo, James V Pottala, Karen L Margolis, Mark A Espeland, Jennifer G Robinson   +5 more
doaj   +1 more source

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid

, 2007
A number of studies have investigated the effects of fish oil on the production of pro-inflammatory cytokines using peripheral blood mononuclear cell models.
Mullen, Anne C, Loscher, Christine E, Weldon, Sinéad M, Roche, Helen M, Hurley, Lisa A   +4 more
core   +1 more source

Essential fatty acids and their long-chain polyunsaturated metabolites in maternal and cord plasma triglycerides during late gestation [PDF]

, 2000
The fatty acid composition of plasma lipids was determined in 41 pairs of mothers and their term infants at time of birth (38-42 postmenstrual weeks) by high-resolution capillary gas-liquid chromatography, Linoleic and alpha-linolenic acids were found at
Koletzko, Berthold, Berghaus, Thomas M., Demmelmair, Hans   +2 more
core   +1 more source

The Evolution of Fatty Acid Desaturases and Cytochrome b5 in Eukaryotes

Journal of Membrane Biology, 2010
Desaturases that introduce double bonds into the fatty acids are involved in the adaptation of membrane fluidity to changes in the environment. Besides, polyunsaturated fatty acids (PUFAs) are increasingly recognized as important pharmaceutical and nutraceutical compounds.
Gostinčar, Cene, Turk, Martina, Gunde-Cimerman, Nina   +2 more
openaire   +3 more sources

Light-induced expression of fatty acid desaturase genes [PDF]

Proceedings of the National Academy of Sciences, 1998
In cyanobacterial cells, fatty acid desaturation is one of the crucial steps in the acclimation processes to low-temperature conditions. The expression of all the four acyl lipid desaturase genes of Synechocystis PCC 6803 was studied as a function of temperature and separately as a function of light.
Kis, M, Zsiros, O, Farkas, T, Wada, H, Nagy, F, Gombos, Z   +5 more
openaire   +3 more sources

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease [PDF]

Nutrients, 2020
Polyunsaturated fatty acids (PUFAs) are considered one of the most important components of cells that influence normal development and function of many organisms, both eukaryotes and prokaryotes. Unsaturated fatty acid desaturases play a crucial role in the synthesis of PUFAs, inserting additional unsaturated bonds into the acyl chain.
Aleksandra Czumaj, Tomasz Śledziński
openaire   +2 more sources

Supplementation with n-3 long-chain polyunsaturated fatty acids or olive oil in men and women with renal disease induces differential changes in the DNA methylation of FADS2 and ELOVL5 in peripheral blood mononuclear cells

, 2014
BACKGROUND: Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation ...
Burdge, Graham C., Mori, T.A., Karen A Lillycrop, Samuel P Hoile, Rebecca Clarke-Harris, Clarke-Harris, R., Graham C Burdge, Beilin, L.J., Philip C Calder, Lawrence J Beilin, Calder, P.C., Huang, R.C., Lillycrop, Karen A., Trevor A Mori, Hoile, Samuel P., Rae-Chi Huang   +15 more
core   +1 more source

An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Δ8-desaturates 20:2n-6 and 20:3n-3

Journal of Lipid Research, 2009
The mammalian Δ6-desaturase coded by fatty acid desaturase 2 (FADS2; HSA11q12-q13.1) catalyzes the first and rate-limiting step for the biosynthesis of long-chain polyunsaturated fatty acids.
Woo Jung Park, Kumar S.D. Kothapalli, Peter Lawrence, Cynthia Tyburczy, J. Thomas Brenna   +4 more
doaj   +1 more source