British Journal of Pharmacology, EarlyView.The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli +6 more
wiley +1 more source
Efficacy of omega-3 fatty acids supplementation as an adjunct to nonsurgical periodontal therapy in periodontitis: a systematic review and meta-analysis of randomized controlled trials. [PDF]
Rev Cient Odontol (Lima)Irmawati A +4 more
europepmc +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
Association between omega-6 fatty acids and diabetic retinopathy risk: a systematic review and meta-analysis. [PDF]
Nutr DiabetesChen KY, Chan HC, Chan CM.
europepmc +1 more source
Ocular Manifestations of Metabolic Syndrome: A Systemic Vascular Phenotype
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Context Metabolic syndrome (MetS) is defined by central obesity, insulin resistance, hypertension and dyslipidemia. MetS affects over one‐third of US adults. Beyond its cardiovascular burden, MetS has clinically relevant associations with ocular health and may contribute to a systemic vascular and neuro‐metabolic phenotype involving the retina,
Ron T. Varghese, Ansu A. John
wiley +1 more source
Palmitoleic acid content and composition-based nutritional quality of commercial omega-7 oils and supplements. [PDF]
Front NutrCorrea M +15 more
europepmc +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest +3 more
wiley +1 more source
Alpha-linolenic acid in cancer: a predictive fate-switch framework for tumor lipid reprogramming. [PDF]
Front OncolZheng J +8 more
europepmc +1 more source
Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic (CKLM) syndrome.
Virginia Anagnostopoulou +5 more
wiley +1 more source
Association between omega-6 and omega-3 fatty acids intake, body mass index and depression in young Iranian adults: a cross sectional study. [PDF]
J Health Popul NutrNaderlou H +5 more
europepmc +1 more source