Results 31 to 40 of about 3,812 (172)

Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo [PDF]

, 2014
Here, we exploit the spatial separation of temporal events of neural differentiation in the elongating chick body axis to provide the first analysis of transcriptome change in progressively more differentiated neural cell populations in vivo.
Abranches, Akai, Altschul, Amijee, Arbeitman, Aubert, Bel-Vialar, Benjamini, Bradford, Brown, Chitnis, Delfino-Machín, Deschamps, Deschenes, Diez del Corral, Diez del Corral, Dittmar, Eblaghie, Fior, Goodwin, Hamburger, Henrique, Irizarry, Jares, Kuhns, Landeira, Lessard, Li, Lobjois, Lunn, Martin, Miettinen, Minowada, Mitiku, Olivera-Martinez, Ozbudak, Ozsolak, Park, Patel, Perry, Rae, Rae, Schurch, Smyth, Smyth, Stavridis, Stern, Storey, Sultan, Tsakiridis, Tzouanacou, van der Vlag, Wilcock, Willnow, Wilson, Wu, Zhang, Zhao   +57 more
core   +16 more sources

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes. [PDF]

, 2017
Changes in gene expression that occur across the central nervous system (CNS) during neurological diseases do not address the heterogeneity of cell types from one CNS region to another and are complicated by alterations in cellular composition during ...
Ao, Yan, Burda, Josh, Farkhondeh, Vista, Itoh, Noriko, Itoh, Yuichiro, Johnsonbaugh, Hadley, Kaito, Max, Ohno, Ai, Ren, Emily, Sofroniew, Michael V, Tassoni, Alessia, Voskuhl, Rhonda R   +11 more
core   +2 more sources

EMC2 promotes triple negative breast cancer growth by protecting FDFT1 from endoplasmic reticulum associated degradation to impair ferroptosis susceptibility. [PDF]

Oncogene
Dong X, Dai H, Yao L, Lin Y, Wang Y, Li Y, Zhang X, Zhou L, Lu J, Yin W.   +9 more
europepmc   +3 more sources

Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes† [PDF]

, 2018
Preventing postpartum uterine disease depends on the ability of endometrial cells to tolerate the presence of the bacteria that invade the uterus after parturition.
Amos, Ayres, Bergstrom, Bergstrom, Bicalho, Billington, Bloch, Bonnett, Bustin, Christian, Cronin, Forman, Fukuchi, Gan, Gareth D Healey, Goldstein, Goldstein, Gonzalez, Griffin, Gurcel, Hardie, Healy, Hiyoshi, Huffman, I Martin Sheldon, Jost, Kalaany, Karstrup, Keller, Lange, LeBlanc, LeBlanc, Liao, Maxfield, McCusker, Mihaylova, Moore, Morgan, Mosmann, Park, Peraro, Preta, Preta, Read, Repa, Schneider, Sharpe, Sheldon, Sheldon, Sholeem Griffin, Statt, Turner, Turner, Tweten, Vander Heiden, Wang, Wathes, Westermann, Zoncu, Zwald   +59 more
core   +1 more source

Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival. [PDF]

, 2004
Background & aimsPathogenesis of gastric cancer is driven by an accumulation of genetic changes that to a large extent occur at the chromosomal level. In order to investigate the patterns of chromosomal aberrations in gastric carcinomas, we performed
Albertson, Donna, Kuipers, Ernst J, Meijer, Gerrit A, Meuwissen, Stefan GM, Pinkel, Daniel, Postma, Cindy, Snijders, Antoine M, Weiss, Marjan M   +7 more
core   +3 more sources

Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway

International Immunopharmacology, 2020
Non-alcoholic fatty liver disease (NAFLD) is a progressive and chronic liver disease. No effective drug is currently approved for the treatment of NAFLD. Traditionally it is thought that pathogenesis of NAFLD develops from some imbalance in lipid control, thereby leading to hepatotoxicity and disease development.
Xi, Dong, Yue, Zhu, Shan, Wang, Yun, Luo, Shan, Lu, Fengwei, Nan, Guibo, Sun, Xiaobo, Sun   +7 more
openaire   +2 more sources

Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis [PDF]

, 2015
Metabolic changes can influence inflammatory responses to bacteria. To examine whether localized manipulation of the mevalonate pathway impacts innate immunity, we exploited a unique mucosal disease model, endometritis, where inflammation is a ...
Bonnett, Christine Collier, David G. Smith, Gareth D. Healey, Hans-Joachim Schuberth, I. Martin Sheldon, Ireland, Isabelle Dieuzy-Labaye, Keller, Mital, Olivier Sandra, Petras, Sholeem Griffin, Sinensky, Suman Mahan   +14 more
core   +2 more sources

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation [PDF]

, 2016
Constitutive activation of Wnt/β-catenin inhibits oligodendrocyte myelination. Tcf7l2/Tcf4, a β-catenin transcriptional partner, is required for oligodendrocyte differentiation.
Clevers, Hans, Deng, Yaqi, Goldman, Steven A, He, Xuelian, Li, Jianrong, Liu, Lei, Lu, Changqing, Lu, Q. Richard, Mao, Meng, Parry, Lee, van Es, Johan H, Wang, Haibo, Wang, Jincheng, Weng, Qinjie, Wu, Laiman N, Xin, Mei, Yu, Kun, Zhang, Liguo, Zhao, Chuntao   +18 more
core   +4 more sources

Functional Polymorphisms of the Lss and Fdft1 Genes in Laboratory Rats

Experimental Animals, 2007
We previously identified mutant alleles of the lanosterol synthase (Lss) and farnesyl diphosphate farnesyl transferase 1 (Fdft1) genes, which function in the cholesterol biosynthesis pathway, as determinants for hereditary cataracts in the SCR rat strain. Lss(S) and Fdft1(S) were established as hypomorphic alleles with missense nucleotide substitutions,
Masayuki, Mori, Jinko, Sawashita, Keiichi, Higuchi   +2 more
openaire   +3 more sources

Transcriptome analysis reveals the effect of grafting on gossypol biosynthesis and gland formation in cotton

BMC Plant Biology, 2023
Background Gossypol is a unique secondary metabolite and sesquiterpene in cotton, which is mainly synthesized in the root system of cotton and exhibits many biological activities.
Kun Ye, Teng Teng, Teng Yang, Degang Zhao, Yichen Zhao   +4 more
doaj   +1 more source