Results 41 to 50 of about 3,812 (172)

Inhibiting mevalonate pathway enzymes increases stromal cell resilience to a cholesterol-dependent cytolysin [PDF]

, 2017
Animal health depends on the ability of immune cells to kill invading pathogens, and on the resilience of tissues to tolerate the presence of pathogens.
A Baxter, A Bellier, A Das, AE Christian, AF Read, B Page, BH Jost, BN Bonnett, CY Kao, DL Huffman, DO Ballard, DS Schneider, EP Kilsdonk, G Krikun, G Preta, GD Healey, IM Sheldon, IM Sheldon, JD Bergstrom, JG Cronin, JL Goldstein, JL Goldstein, JM Park, JW Rosch, K Bloch, KS Giddings, L Gurcel, L Pokrajac, L Raberg, LJ Bischof, LJ Sharpe, MD Peraro, MJ Rogers, ML Turner, MLS Bicalho, MR Amos, MR Gonzalez, R Medzhitov, RK Tweten, S Statt, S Westermann, SA Bustin, SJ Billington, SJ Billington, SJ Billington, T Mosmann, Y Lange   +46 more
core   +2 more sources

Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment [PDF]

, 2016
AIMS: The main objective of the study is molecular and biological characterization of the human-yeast hybrid squalene synthase (SQS), as a promising target for treatment of hypercholesterolaemia.
Burzynska, Beata, Danikiewicz, Witold, Gora, Monika, Kapur, S., Komaszylo, Joanna, Leszczynska, Agata, Maciejak, Agata, Plochocka, Danuta, Sojka, M., Swiezewska, Ewa, Tułacz, Dorota, Warchol, I., Wysocka-Kapcinska, Monika   +12 more
core   +1 more source

Herbal Diet and the Impact of Nutrition on Lipogenic Activity, a System Biology Study [PDF]

Research Journal of Pharmacognosy, 2023
Background and objectives: Human diet is branded with higher caloric and protein content and cooking processes in comparison with the diet of the primate species. The aim of this study was to explore the differences between human diet and chimpanzee diet
Mostafa Rezaei Tavirani, Reza Mohamoud Robati*, Alireza Ahmadzadeh, Mohammad Rostami Nejad   +3 more
doaj   +1 more source

MicroRNA-483 amelioration of experimental pulmonary hypertension. [PDF]

, 2020
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit.
Bai, Liang, Chen, Shanshan, Chou, Chih-Hung, Cui, Xiaopei, Fan, Fenling, Gongol, Brendan, Gu, Mingxia, He, Ming, He, Yangyang, Huang, Hsien-Da, Jing, Zhi-Cheng, Lei, Yuyang, Li, Zhao, Malhotra, Atul, Miao, Yifei, Rabinovitch, Marlene, Shen, Yuan, Shyy, John Y-J, Wang, Xiaojian, Yan, Xiaosong, Zhang, Jiao, Zhang, Jin, Zhang, Yixin   +22 more
core   +1 more source

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages. [PDF]

, 2018
Activation of liver X receptors (LXRs) with synthetic agonists promotes reverse cholesterol transport and protects against atherosclerosis in mouse models.
Bahadorani, John, Edillor, Chantle R, Glass, Christopher K, Grossman, Tamar R, Henke, Adam, McDonald, Jeffrey G, Muse, Evan D, Ozeki, Katherine A, Roland, Jason T, Seidman, Jason S, Spann, Nathanael J, Tao, Jenhan, Thompson, Bonne M, Tremblay, Matthew S, Troutman, Ty D, Tsimikas, Sotirios, Yu, Shan   +16 more
core   +1 more source

Localization of the Squalene Synthase Gene (FDFT1) to Human Chromosome 8p22-p23.1

Genomics, 1994
Recently, we reported the isolation of a cDNA encoding the human enzyme squalene synthase, the first step of sterol biosynthesis uniquely committed to synthesis of cholesterol (6). As such, it is likely that this enzyme occupies a critical regulatory position in the synthesis of cholesterol.
I, Shechter, D G, Conrad, I, Hart, R C, Berger, T L, McKenzie, J, Bleskan, D, Patterson   +6 more
openaire   +2 more sources

STAT3-mediated allelic imbalance of novel genetic variant Rs1047643 and B-cell-specific super-enhancer in association with systemic lupus erythematosus

eLife, 2022
Mapping of allelic imbalance (AI) at heterozygous loci has the potential to establish links between genetic risk for disease and biological function. Leveraging multi-omics data for AI analysis and functional annotation, we discovered a novel functional ...
Yanfeng Zhang, Kenneth Day, Devin M Absher   +2 more
doaj   +1 more source

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Communications Biology, 2023
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun, Diming Liu, Weiwei Cui, Huimin Cheng, Lixia Huang, Ruihao Zhang, Junlian Gu, Shuo Liu, Xiao Zhuang, Yi Lu, Bo Chu, Jian Li   +11 more
doaj   +1 more source

Comparative Analysis of Muscle Transcriptome between Pig Genotypes Identifies Genes and Regulatory Mechanisms Associated to Growth, Fatness and Metabolism. [PDF]

, 2015
Iberian ham production includes both purebred (IB) and Duroc-crossbred (IBxDU) Iberian pigs, which show important differences in meat quality and production traits, such as muscle growth and fatness.
Ayuso, Miriam, Barragán, Carmen, Benítez, Rita, Cánovas, Ángela, Fernández, Almudena, Fernández, Ana Isabel, González-Bulnes, Antonio, Isabel, Beatriz, López-Bote, Clemente, Medrano, Juan F, Núñez, Yolanda, Ovilo, Cristina, Rey, Ana Isabel   +12 more
core   +4 more sources

Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer

International Journal of Genomics, 2018
Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors.
Mehdi Dehghani, Zahra Samani, Hassan Abidi, Leila Manzouri, Reza Mahmoudi, Saeed Hosseini Teshnizi, Mohsen Nikseresht   +6 more
doaj   +1 more source