Results 71 to 80 of about 3,812 (172)

Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture [PDF]

, 2013
Halloysite is aluminosilicate clay with a hollow tubular structure with nanoscale internal and external diameters. Assessment of halloysite biocompatibility has gained importance in view of its potential application in oral drug delivery.
Agarwal, Mangilal, Lai, Xianyin, Lvov, Yuri M., Pachpande, Chetan, Varahramyan, Kody, Witzmann, Frank A.   +5 more
core   +1 more source

Cholesterol de novo Biosynthesis in Paired Samples of Breast Cancer and Adjacent Histologically Normal Tissue: Association with Proliferation Index, Tumor Grade, and Recurrence-Free Survival [PDF]

, 2023
Background: Cholesterol is an essential component of cell membranes whose local de novo biosynthesis may occur in response to additional cellular requirements, especially cell proliferation.
Danila Coradini, Federico Ambrogi, Gabriele Infante   +2 more
core   +1 more source

Unilateral mastication‐induced memory deficits linked to disrupted hippocampal cholesterol metabolism in rats

VIEW, EarlyView.
Unilateral mastication, a common oral habit, induces cognitive decline in rats by disrupting hippocampal cholesterol metabolism. It triggers astrocyte hyperplasia, enhances cholesterol synthesis, impairs transport/degradation, and reduces 24‐hydroxycholesterol (24‐OHC), ultimately damaging synaptic function.
Xiaoting Zhai, Yifan Hu, Rongchen Xu, Xinyu Xu, Bowen Ma, Dongzong Huang, Hongchen Liu, Hongbo Li, Yuan Hu, Hua Jiang   +9 more
wiley   +1 more source

Transcriptome profiling of granulosa cells of bovine ovarian follicles during growth from small to large antral sizes [PDF]

, 2014
Background: At later stages of folliculogenesis, the mammalian ovarian follicle contains layers of epithelial granulosa cells surrounding an antral cavity.
Harland, M., Hatzirodos, N., Hummitzsch, K., Irving-Rodgers, H., Morris, S., Rodgers, R.   +5 more
core   +2 more sources

Gene Expression in Embryos From Norwegian Red Bulls With High or Low Non Return Rate: An RNA-Seq Study of in vivo-Produced Single Embryos [PDF]

, 2022
publishedVersio
Diaz-Lundahl, Anna Sofia, Gilfillan, Gregor, Gillund, Per, Krogenæs, Anette Kristine, Olsaker, Ingrid, Sundaram, Arvind Y.M.   +5 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma

BMC Cancer, 2021
Background and aim Lipid metabolic reprogramming is considered to be a new hallmark of malignant tumors. The purpose of this study was to explore the expression profiles of lipid metabolism-related genes (LMRG) in colorectal cancer (CRC).
Chao Yang, Shuoyang Huang, Fengyu Cao, Yongbin Zheng   +3 more
doaj   +1 more source

Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context

Biomedicines, 2021
A global protein interactome ensures the maintenance of regulatory, signaling and structural processes in cells, but at the same time, aberrations in the repertoire of protein–protein interactions usually cause a disease onset.
Pavel Ershov, Leonid Kaluzhskiy, Yuri Mezentsev, Evgeniy Yablokov, Oksana Gnedenko, Alexis Ivanov   +5 more
doaj   +1 more source

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell, Joshua A. Kulas, William E. Carter, June Javens‐Wolfe, Raven Dance Hinkel, Mustapha Moussaif, Jacob S. Smiley, Olivia Lazaro, Sylvia Robertson, Alan D. Palkowitz, Bruce T. Lamb, Timothy I. Richardson, Jeffrey L. Dage, Shaoyou Chu, Travis Johnson, Louis F. Stancato, Abdul Qadir Syed   +16 more
wiley   +1 more source

Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington's disease mice [PDF]

, 2015
Brain cholesterol biosynthesis and cholesterol levels are reduced in mouse models of Huntington's disease (HD), suggesting that locally synthesized, newly formed cholesterol is less available to neurons.
Alessandro Vercelli, Barbara Ruozi, Carlos Cepeda, Claudio Caccia, Costanza Ferrari Bardile, Daniela Belletti, Elena Cattaneo, Eleonora Di Paolo, Elisa Brilli, Flavio Forni, Giovanni Tosi, HDCRG, Jane Y Chen, Maria A Vandelli, Marina M Boido, Marta Valenza, Marullo M, Michael S Levine, Paxinos G, Sethi A, Stefano Di Donato, Trager U, Valerio Leoni   +22 more
core   +4 more sources