Results 81 to 90 of about 4,897,809 (228)

Integrating Genetic Modifier Genotype With Serum Proteomics in Duchenne Muscular Dystrophy Clinical Trials Links LTBP4 Genetic Modifier to IL‐23/CD93 Pathways in Muscle

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Genetic modifiers of Duchenne muscular dystrophy (DMD) that alter disease severity or response to therapy have been reported using natural history or registry data sets of older corticosteroid‐treated patients. We tested associations of genetic modifiers on motor function outcomes in young (4 to < 7 years) steroid naïve clinical trial ...
Utkarsh J. Dang, Yuan Fang, Daniele Sabbatini, Elena Pegoraro, Luca Bello, Paula R. Clemens, Michela Guglieri, John van den Anker, Jesse Damsker, Laura Hagerty, Yetrib Hathout, Michael Ziemba, Lauren Morgenroth, Surajit Bhattacharya, Kanneboyina Nagaraju, Jyoti K. Jaiswal, Eric P. Hoffman   +16 more
wiley   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Fibroblast activation protein is induced by inflammation and degrades type I collagen in thin-cap fibroatheromata [PDF]

, 2011
Aims Collagen degradation in atherosclerotic plaques with thin fibrous caps renders them more prone to rupture. Fibroblast activation protein (FAP) plays a role in arthritis and tumour formation through its collagenase activity. However, the significance
Stephan Winnik, Elena Aikawa, Christine Lohmann, Christoph Renner, Chad E. Brokopp, Peter Richards, Weber, B, Maximilian Y. Emmert, Thomas F. Lüscher, Aikawa, E, Roman Schoenauer, Emmert, M Y, Renner, C, Bauer, S, Schoenauer, R, Richards, P, Kirk Graves, Michele Genoni, Hoerstrup, S P, Winnik, S, Stefan Bauer, Christian M. Matter, Lohmann, C, Graves, K, Vogt, P, Genoni, M, Lüscher, Thomas F; https://orcid.org/, Simon P. Hoerstrup, Matter, C M, Brokopp, C E, Benedikt Weber, Peter Vogt, Richards P, Emmert MY, Schoenauer R, Lüscher TF, Renner C, Bauer S, Lohmann C, Matter CM, Genoni M, Winnik S, Weber B, Brokopp CE, Aikawa E, Graves K, Vogt P, Hoerstrup SP   +47 more
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Cancer-Associated Fibroblasts: Clinical Applications in Imaging and Therapy

Tomography
Cancer-associated fibroblasts (CAFs) are an abundant and diverse cell population within tumor microenvironments of solid tumors. Multiple subtypes of CAFs, defined by molecular and functional markers, have been described in the literature.
Neda Nilforoushan, Ashkan Khavaran, Maierdan Palihati, Yashvi Patel, Anna O. Giarratana, Jeeban Paul Das, Kathleen M. Capaccione   +6 more
doaj   +1 more source

Inhibitor-conjugated harmonic nanoparticles targeting fibroblast activation protein [PDF]

, 2019
The recent progress in the engineering of nanosized inorganic materials presenting tailored physical properties and reactive surface for post-functionalization has opened promising avenues for the use of nanoparticles (NPs) in diagnosis and therapeutic ...
De Matos, Raphaël, Staedler, D., Constant, Samuel, Gerber-Lemaire, S., Staedler, Davide, Gerber-Lemaire, Sandrine, De Matos, R., Mas, C., Constant, S., Gerber, Sandrine, Vuilleumier, Jérémy, Vuilleumier, J., Mas, Christophe   +12 more
core   +1 more source

Next‐Generation CAR‐T Cell Therapy: From Modular Design to Clinical Expansion

Exploration, EarlyView.
Over the past decades, chimeric antigen receptor (CAR)‐T cell therapy has evolved from a linear engineering concept into a powerful yet constrained immunotherapy, limited by tumour microenvironment barriers, immune evasion, and manufacturing complexity.
Yuesong Bai, Jintao Qin, Zongjun Dai, Ran Yan, Yong Yang, Wenguang Wang   +5 more
wiley   +1 more source

Druglike, \ub9\u2078F-labeled PET tracers targeting fibroblast activation protein (FAP)

: Fibroblast activation protein (FAP) is a very reliable biomarker for tissue remodeling. FAP has so far mainly been studied in oncology, but there is growing interest for the enzyme in other diseases like fibrosis. Recently FAP-targeting diagnostics and
De Loose, Joni, De Meester, Ingrid, van der Veken, Pieter, Verhulst, Emile, Moon, Euy Sung, Roesch, Frank, Elvas, Filipe, Cianni, Lorenzo, Tanc, Muhammet, Stroobants, Sigrid, Pintelon, Isabel, Van Rymenant, Yentl, Grintsevich, Sergei, Verschuuren, Marlies, Augustyns, Koen, Filippi, Nicol\uf2   +15 more
core   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Targeting fibroblast activation protein in rheumatoid arthritis: from molecular imaging to precision therapeutics

Frontiers in Immunology
Rheumatoid arthritis (RA), a chronic inflammatory disorder characterized by synovitis and joint destruction, remains a global health challenge. Activated fibroblast-like synoviocytes (FLS), which play a crucial role in the progression of RA, demonstrate ...
Yupeng Huang, Yang Wu, Huan Liu, Yuehong Chen, Qibing Xie, Geng Yin   +5 more
doaj   +1 more source