Results 161 to 170 of about 5,605 (194)

Thiol isomerase ERp57 targets and modulates the lectin pathway of complement activation [PDF]

, 2019
Atkinson, John P., Chiu, Joyce, Eriksson, Oskar, Flaumenhaft, Robert, Furie, Bruce, Hogg, Philip J., Liszewski, M. Kathryn   +6 more
core   +1 more source

Complement system dysfunction in autism spectrum disorder: evidence for altered C1q and C3 levels (complement system dysfunction in ASD). [PDF]

Acta Neuropsychiatr
Gunaydin M, Dogan O, Gunay F, Cikili-Uytun M, Celik-Buyukceran Ö, Oztop DB.   +5 more
europepmc   +1 more source

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Ficolin-2 recognizes DNA and participates in the clearance of dying host cells

Molecular Immunology, 2007
Ficolin-2 is a serum opsonin, which has been shown to be a pattern recognition molecule in the lectin complement activation pathway. Because innate immune mechanisms are involved in maintaining tissue homeostasis we hypothesized that Ficolin-2 also participate in the clearance of dying host cells.
Christian Honoré, Tina Hummelshøj, Hans Ole Madsen   +2 more
exaly   +3 more sources

Molecular organization of human Ficolin-2

Molecular Immunology, 2007
Human Ficolin-2 (L-Ficolin) is an oligomeric serum protein consisting of a collagen-like stalk and fibrinogen-like recognition domains. The protein binds to arrays of sugars present on different microorganisms, enhances phagocytosis and promotes activation of the lectin complement pathway.
Tina, Hummelshoj, Nicole M, Thielens, Hans O, Madsen, Gérard J, Arlaud, Robert B, Sim, Peter, Garred   +5 more
openaire   +2 more sources

Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria

Human Immunology, 2011
Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis. Here, we investigate the clinical significance of FCN2 in African children with either mild or severe malaria (n = 130 and n = 108, respectively) from Gabon by analyzing three promoter SNPs (-986G>A, -602G>A, and -4A>G)
Imad, Faik, Segun I, Oyedeji, Zulkarnain, Idris, Iara J, de Messias-Reason, Bertrand, Lell, Peter G, Kremsner, Jürgen F J, Kun   +6 more
openaire   +2 more sources

Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease

Journal of Dermatological Science, 2006
Genetic susceptibility to Behçet's disease (BD) is well documented for HLA-B51 positivity. However, BD is not a simple hereditary disease and it is exaggerated by exogenous stimuli such as microorganisms' infections. Ficolin 2 is a lectin that binds to the surface of microbial cells and kills microbial cells through the activation of complement system.
Xixue, Chen, Yasunobu, Katoh, Koichiro, Nakamura, Noritaka, Oyama, Fumio, Kaneko, Yuichi, Endo, Teizo, Fujita, Tomomi, Nishida, Nobuhisa, Mizuki   +8 more
openaire   +2 more sources

Serum Ficolin-2 in Hospitalised Patients with Community-Acquired Pneumonia

Inflammation, 2014
Mannose binding lectin (MBL) and ficolins contribute to host defence through activation of the lectin pathway of complement. In this study, serum levels of ficolin-2 and MBL were determined in 276 patients with community-acquired pneumonia (CAP). MBL deficiency and ficolin-2 insufficiency were defined using previously validated cut-offs. No differences
Chalmers, James D., Fleming, Gilly B., Rutherford, Julia, Matsushita, Misao, Kilpatrick, David C., Hill, Adam T.   +5 more
openaire   +3 more sources

Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells

Clinical Immunology, 2017
Ficolin-2 is an important serum complement lectin. Here, we describe novel findings indicating that serum ficolin-2 concentrations in multiple tumor patients are significantly lower than those in healthy donors. Administration of exogenous ficolin-2 or ficolin-A (a ficolin-2-like molecule in mouse), with only once, could remarkably inhibit the tumor ...
Yanying Shen, Dongqing Li, Zhinan Yin
exaly   +3 more sources

Hemodialysis leads to plasma depletion of lectin complement pathway initiator molecule ficolin‐2

Hemodialysis International, 2021
AbstractIntroductionThis study aimed to investigate changes in complement system‐related molecules in patients undergoing hemodialysis.MethodsPatients >18 years of age on maintenance hemodialysis were included. Using enzyme‐linked immunosorbent assays (ELISA) methods complement related molecules ficolin‐1, ficolin‐2, ficolin‐3 mannose‐binding lectin,
Ture Lange Nielsen, Katrine Pilely, Kit P. Lund, Peder Emil Warming, Louis Lind Plesner, Kasper Karmark Iversen, Peter Garred   +6 more
openaire   +3 more sources

ApoE3 blocks HCV entry inhibitor ficolin-2 (INM8P.437)

The Journal of Immunology, 2014
Abstract Human ficolin-2 is a lectin-complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during chronic Hepatitis C Virus (HCV) infection.
Xiao-Lian Zhang, Yushan Yushan Ren, Yinglan Zhao   +2 more
openaire   +1 more source