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Molecular Cloning and Characterization of Mouse Ficolin-A
Biochemical and Biophysical Research Communications, 1998A novel ficolin-related gene was isolated from the mouse liver lambda ZAPII cDNA library. The protein encoded by this gene consists of both collagen- and fibrinogen-like domains, which are common features of the ficolin family, and was named mouse ficolin-A. The amino acid sequence of mouse ficolin-A is 60.2, 59.8, 59.8, and 59.6% identical to those of
Y, Fujimori +6 more
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Molecular organization of human Ficolin-2
Molecular Immunology, 2007Human Ficolin-2 (L-Ficolin) is an oligomeric serum protein consisting of a collagen-like stalk and fibrinogen-like recognition domains. The protein binds to arrays of sugars present on different microorganisms, enhances phagocytosis and promotes activation of the lectin complement pathway.
Tina, Hummelshoj +5 more
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Ficolins: Structure, Function and Associated Diseases
2008Innate immunity relies upon the ability of a few pattern recognition molecules to sense molecular markers. Ficolins are humoral molecules of the innate immune systems which recognize carbohydrate molecules on pathogens, apoptotic and necrotic cells. Three ficolins have been identified in humans: L-ficolin, H-ficolin and M-ficolin (also referred to as ...
Xiao-Lian, Zhang, Mohammed A M, Ali
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