Results 81 to 90 of about 7,998 (276)

Insufficient serum L-ficolin is associated with disease presence and extent of pulmonary Mycobacterium avium complex disease

Respiratory Research, 2019
Background The incidence of infectious disease caused by nontuberculous mycobacteria is increasing worldwide. Pulmonary Mycobacterium avium complex (MAC) disease is difficult to treat with chemotherapy, and its mechanism of infection, infection route ...
Tomofumi Kobayashi, Koji Kuronuma, Atsushi Saito, Kimiyuki Ikeda, Shigeru Ariki, Atsushi Saitou, Mitsuo Otsuka, Hirofumi Chiba, Satoshi Takahashi, Motoko Takahashi, Hiroki Takahashi   +10 more
doaj   +1 more source

Mouse mannose-binding lectin-A and ficolin-A inhibit lipopolysaccharide-mediated pro-inflammatory responses on mast cells [PDF]

BMB Reports, 2013
It is unknown how soluble pattern-recognition receptors inblood, such as mannose-binding lectin (MBL) and ficolins,modulate mast cell-mediated inflammatory responses. Weinvestigate how mouse MBL-A or ficolin-A regulate mouse bonemarrow-derived mast cells
Ying Jie Ma, Hee Jung Kang, Ji Yeon Kim, Peter Garred, Myung-Shik Lee, Bok Luel Lee   +5 more
doaj   +1 more source

Genetic Polymorphism of Ficolin-2 in Arctic Populations

Doctor Ru
Aim. To study the prevalence of polymorphisms rs17549193 and rs7851696 of the ficolin-2 gene FCN2 among the Nenets, Dolgan-Nganasan and Slavic populations using a molecular genetic study of single nucleotide polymorphisms. Design.
K. Afonicheva, E.V. Kasparov, I. Marchenko, M. Smolnikova   +3 more
semanticscholar   +1 more source

M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis

Archives of Disease in Childhood, 2021
Objective Distinction on clinical grounds between acute lymphoblastic leukaemia presenting with arthropathy (ALLarthropathy) and juvenile idiopathic arthritis (JIA) is difficult, as the clinical and paraclinical signs of leukaemia may be vague.
Ninna Brix, M. Glerup, S. Thiel, C. Mistegaard, R. G. Skals, L. Berntson, A. Fasth, S. Nielsen, E. Nordal, M. Rygg, H. Hasle, B. Albertsen, T. Herlin   +12 more
semanticscholar   +1 more source

Ficolin-1 and Ficolin-3 Plasma Levels Are Altered in HIV and HIV/HCV Coinfected Patients From Southern Brazil

Frontiers in Immunology, 2018
The complement system is a key component of the innate immune system, participating in the surveillance against infectious agents. Once activated by one of the three different pathways, complement mediates cell lysis, opsonization, signalizes pathogens ...
Maria Regina Tizzot, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Hellen Weinschutz Mendes, Marcia Holsbach Beltrame, Edna Reiche, Steffen Thiel, Jens C. Jensenius, Iara J. de Messias-Reason   +8 more
doaj   +1 more source

Local and Systemic Concentrations of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases

Frontiers in Immunology, 2020
BackgroundThe role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via ...
Severin Vogt, Severin Vogt, Marten Trendelenburg, Marten Trendelenburg, Marten Trendelenburg, Michael Tamm, Michael Tamm, Daiana Stolz, Daiana Stolz, Katrin Esther Hostettler, Katrin Esther Hostettler, Michael Osthoff, Michael Osthoff, Michael Osthoff   +13 more
doaj   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

Advanced Science, Volume 12, Issue 18, May 15, 2025.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi, Yanxia Wang, Huan Chen, Kaitian Wu, Pei Zhou, Yue Dou, Bingqi Xiong, Wei Zhou   +7 more
wiley   +1 more source

Engineering novel complement activity into a pulmonary surfactant protein [PDF]

, 2010
Complement neutralizes invading pathogens, stimulates inflammatory and adaptive immune responses, and targets non- or altered-self structures for clearance.
Anthony H. Keeble, Brodsky-Doyle, Chen, Chen, Christopher Furze, Daniel A. Mitchell, Doliana, Emsley, Fan, Feinberg, Girija, Haurum, Heise, Hohenester, Hoppe, Jensenius, Julia Toth, Kaufman, Kurata, Phillips, Porter, Reid, Reid, Reid, Russell Wallis, Scherer, Shoulders, Sim, Strang, Teillet, Uemura, Umakhanth Venkatraman Girija, Wallis, Wallis, Wallis, Wallis, Wallis, Wallis, Wilhelm J. Schwaeble   +38 more
core   +2 more sources

Association of mannose-binding lectin, ficolin-2 and immunoglobulin concentrations with future exacerbations in patients with chronic obstructive pulmonary disease: secondary analysis of the randomized controlled REDUCE trial

Respiratory Research, 2021
Background The innate and adaptive immune system is involved in the airway inflammation associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD).
S. Vogt, J. Leuppi, P. Schuetz, B. Mueller, C. Volken, Sarah Dräger, M. Trendelenburg, J. Rutishauser, M. Osthoff   +8 more
semanticscholar   +1 more source

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
EVs were isolated from plasma of ME/CFS patients and healthy controls at baseline, and 15 min and 24 h postexercise. Untargeted proteomics revealed dysregulation in energy metabolism, the complement system, and the endoplasmic reticulum stress response. Changes in EV protein levels postexercise are associated with post‐exertional malaise.
Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson   +3 more
wiley   +1 more source