Results 1 to 10 of about 11,223 (224)

Proteomic analysis of a filaggrin-deficient skin organoid model shows evidence of increased transcriptional-translational activity, keratinocyte-immune crosstalk and disordered axon guidance [version 1; peer review: 2 approved, 1 approved with reservations] [PDF]

Wellcome Open Research, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads
Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown   +8 more
doaj   +4 more sources

Tuning the Cell-Free Protein Synthesis System for Biomanufacturing of Monomeric Human Filaggrin [PDF]

Frontiers in Bioengineering and Biotechnology, 2020
The modern cell-free protein synthesis (CFPS) system is expanding the opportunity of cell-free biomanufacturing as a versatile platform for synthesizing various therapeutic proteins.
Jeehye Kim, Caroline E. Copeland, Kosuke Seki, Kosuke Seki, Bastian Vögeli, Yong-Chan Kwon, Yong-Chan Kwon   +6 more
doaj   +3 more sources

Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions [PDF]

BMC Biology
Background Atopic dermatitis (AD) is a highly prevalent inflammatory skin disease, affecting up to 30% of children at some point in their life and frequently persisting into adulthood.
Adrian Kobiela, Mikołaj Klimczuk, Paweł Kamil Serafin, Kamila Kitowska, Anna Biernacka, Reza Abouali, Jorge Bernardino de la Serna, Xinwen Wang, Felicja Gajdowska, Aniela Kosobucka, Aleksandra Małgorzata Siedlar, Amandine Hauer, Lilit Hovhannisyan, Aleksandra Bogucka, Jos P. H. Smits, Ellen H. van den Bogaard, Rafał Sądej, Graham S. Ogg, Danuta Gutowska-Owsiak   +18 more
doaj   +2 more sources

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model [version 2; peer review: 3 approved] [PDF]

Wellcome Open Research, 2019
Background: Atopic eczema is an itchy inflammatory disorder characterised by skin barrier dysfunction. Loss-of-function mutations in the gene encoding filaggrin (FLG) are a major risk factor, but the mechanisms by which filaggrin haploinsufficiency leads
Martina S. Elias, Sheila C. Wright, William V. Nicholson, Kimberley D. Morrison, Alan R. Prescott, Sara Ten Have, Phillip D. Whitfield, Angus I. Lamond, Sara J. Brown   +8 more
doaj   +5 more sources

Modulation of Moisturizing and Barrier Related Molecular Markers by Extracellular Vesicles Derived from Leuconostoc mesenteroides DB-21 Isolated from Camellia japonica Flower [PDF]

Current Issues in Molecular Biology
Among the microorganisms present in the microbiome of Camellia japonica flowers, extracellular vesicles (EVs) derived from Leuconostoc mesenteroides were isolated to investigate their modulatory effects on moisturizing and barrier-related molecular ...
Junseok Baek, Seongguk Cho, Gibok Lee, Hosam Ki, Su Young Kim, Gyu-min Choi, Jae Hong Kim, Ji-Woong Kim, Chang-Min Park, Seung-Young Kim, Byeong-Min Choi, Yang Gyu Choi   +11 more
doaj   +2 more sources

Cannabidiol Mitigates Pollution-Induced Inflammatory, Oxidative, and Barrier Damage in Ex Vivo Human Skin [PDF]

Biomolecules
Airborne particulate matter (PM) is a major environmental pollutant that accelerates skin aging, inflammation, and barrier impairment. Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has shown anti-inflammatory and ...
Wannita Klinngam, Orathai Loruthai, Sornkanok Vimolmangkang   +2 more
doaj   +2 more sources

The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction [PDF]

World Allergy Organization Journal
Background: House dust mite (HDM) allergens can induce or exacerbate allergic inflammation, including atopic dermatitis (AD). Substances that damage the epithelial barrier can trigger or worsen AD.
Shan Liu, BSc, Ze-Lang Cai, MS, Jingcheng Liu, Si-Yi Que, BSc, Wan-Zhen Hu, MS, Liang Chen, MS, Jia-Jie Chen, PhD, Kunmei Ji, PhD   +7 more
doaj   +2 more sources

Protective Effect of Peony (Paeonia ostii) Flower Extract Against Tape Stripping-Induced Skin Barrier Impairment in Mice [PDF]

Molecules
Background: Skin barrier dysfunction leads to increased transepidermal water loss (TEWL), inflammation, and compromised skin protection. While Paeonia ostii (peony) flowers are recognized in traditional Chinese medicine for their reducing melanin ...
Ruiying Yang, Jicheng Yang, Gaiying He, Yusheng Zhang, Xue Jiang, Jiyong Wang, Hongjun Yang, Chengxiang Shang   +7 more
doaj   +2 more sources

Filaggrin silencing by shRNA directly impairs the skin barrier function of normal human epidermal keratinocytes and then induces an immune response [PDF]

Brazilian Journal of Medical and Biological Research, 2014
The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation.
N.N. Dang, S.G. Pang, H.Y. Song, L.G. An, X.L. Ma   +4 more
doaj   +3 more sources

Crossing Barriers; Restoring Barriers? Filaggrin Protein Replacement Takes a Bow [PDF]

Journal of Investigative Dermatology, 2014
In this issue of the Journal, Stout and colleagues report a novel and creative approach to replacement of genetically determined absence or deficiency of epidermal proteins. While these early data are certainly interesting, further validation work is required to determine the utility of this approach in genodermatoses.
Miajlovic, Helen, Fallon, Padraic G., Irvine, Alan D., Foster, Timothy J.   +3 more
openaire   +7 more sources