Results 11 to 20 of about 11,223 (224)

Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte

Frontiers in Pharmacology, 2021
Edible bird’s nest (EBN) has been consumed as a Chinese delicacy for hundreds of years; the functions of which have been proposed to prevent lung disease, strengthen immune response, and restore skin youthfulness. To support the skin function of EBN, the
Queenie Wing Sze Lai, Queenie Wing Sze Lai, Maggie Sui Sui Guo, Maggie Sui Sui Guo, Kevin Qiyun Wu, Kevin Qiyun Wu, Zhitao Liao, Dongshi Guan, Tina Tingxia Dong, Tina Tingxia Dong, Penger Tong, Karl Wah Keung Tsim, Karl Wah Keung Tsim   +12 more
doaj   +1 more source

Filaggrin and Atopic Dermatitis: Clinical and Pathogenetic Parallels and Therapeutic Possibilities

Вопросы современной педиатрии, 2021
Atopic dermatitis (AtD) is multifactorial inflammatory skin disease, one of the aspects of its pathogenesis is epidermal barrier dysfunction. Early development of AtD is associated with filaggrin dysfunction.
Nikolay N. Murashkin, Roman A. Ivanov, Eduard T. Ambarchian, Roman V. Epishev, Alexander I. Materikin, Leonid A. Opryatin, Alena A. Savelova   +6 more
doaj   +1 more source

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Modern View on the Role of Epidermal Barrier in Atopic Phenotype Development in Children

Вопросы современной педиатрии, 2020
Epidermal barrier is one is one of the most important structures of the skin, it performs protective function, ensure internal environment constancy by selective ions and molecules transport and by transepidermal water loss regulation.
Nikolay N. Murashkin, Alena A. Savelova, Roman A. Ivanov, Dmitri V. Fedorov, Leonid A. Opryatin, Wasel Ahmad   +5 more
doaj   +1 more source

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

PLoS ONE, 2020
Skin aspartic acid protease (SASPase) is believed to be a key enzyme involved in filaggrin processing during epidermal terminal differentiation. Since little is known about the regulation of SASPase function, the aim of this study was to identify ...
Mark Donovan, Mélanie Salamito, Agnès Thomas-Collignon, Lucie Simonetti, Stephanie Desbouis, Jean-Christophe Rain, Etienne Formstecher, Dominique Bernard   +7 more
doaj   +1 more source

Expression of keratins, epidermal proteins and inflammatory cells in superficial pemphigus dogs [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
Superficial pemphigus in dogs is an autoimmune skin disorder. The disease is characterised by the binding of auto-antibodies to desmosomal molecules including desmocollin-1, a major auto-antigen in dogs.
S. Theerawatanasirikul, A. Rungsipipat, W. Banlunara , P. Pongket   +3 more
doaj   +1 more source

1-Iodohexadecane Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice: Possible Involvements of the Skin Barrier and Mast Cell SNARE Proteins

Molecules, 2022
Atopic dermatitis (AD) is a chronic inflammatory dermal disease with symptoms that include inflammation, itching, and dry skin. 1-Iodohexadecane is known as a component of Chrysanthemum boreale essential oil that has an inhibitory effect on AD-like ...
Do Yoon Kim, Kyung-Jong Won, Dae Il Hwang, Nan Young Kim, Bokyung Kim, Hwan Myung Lee   +5 more
doaj   +1 more source

Associations of filaggrin gene loss-of-function variants and human papillomavirus-related cancer and pre-cancer in Danish adults. [PDF]

PLoS ONE, 2014
Filaggrin proteins are expressed in the skin, oral cavity, oesophagus, and cervical mucose. Loss-of-function mutations in the filaggrin gene (FLG) reduce filaggrin expression and cause an impaired skin barrier function.
Tea Skaaby, Lise Lotte N Husemoen, Torben Jørgensen, Jeanne D Johansen, Torkil Menné, Pal B Szecsi, Steen Stender, Peter Bager, Jacob P Thyssen, Allan Linneberg   +9 more
doaj   +1 more source

Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies [PDF]

, 2016
OBJECTIVES: Autophagy may represent a functional processing event that creates a substrate for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since autophagy is a key cellular event involved in the generation of ...
Alessandra Nerviani, Antonella Capozzi, Cristiano Alessandri, Cristina Iannuccelli, Emanuela Lococo, Guido Valesini, Kato, Manuela Di Franco, Maurizio Sorice, Michele Bombardieri, Neumann, Pickl, Roberta Misasi, Tina Garofalo, Valeria Manganelli   +14 more
core   +1 more source

Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown [PDF]

Journal of Dermatological Science, 2017
Deimination (also known as citrullination), the conversion of arginine in a protein to citrulline, is catalyzed by a family of enzymes called peptidylarginine deiminases (PADs). Three PADs are expressed in the epidermis, one of their targets being filaggrin.
Cau, Laura, Pendaries, Valérie, Lhuillier, Emeline, Thompson, Paul, Serre, Guy, Takahara, Hidenari, Mechin, Marie-Claire, Simon, Michel   +7 more
openaire   +4 more sources