Results 21 to 30 of about 11,223 (224)

Barrier proteins and eosinophilic esophagitis in children: the role of E-cadherin and filaggrin

Allergologia et Immunopathologia, 2022
This study aimed to assess the protein expression of E-cadherin and filaggrin (FLG) in the oesophagus of paediatric and adolescent patients diagnosed with eosinophilic esophagitis (EoE). It is a cross-sectional study conducted with 24 patients with EoE and 17 control patients, from June 2015 to June 2018.
Erica Rezende, Mariza Faria, Ignez Candelori, Juliana S Daud, Flavia A Alves, Jair Cunha Junior, Gesmar Silva Segundo   +6 more
openaire   +2 more sources

Mechanism of improving skin barrier function in a mouse model of atopic dermatitis using Mahuang Lianqiao Chixiaodou decoction and its disassembled formula

Journal of Traditional Chinese Medical Sciences, 2021
Objective: To reveal the mechanism of Mahuang Lianqiao Chixiaodou decoction and its disassembled formula for improving the skin barrier function in a mouse model of atopic dermatitis (AD).
Jingang Liu, Yan Sun, Huimin Yuan, Yuda Li, Jing Feng, Yushan Gao, Yang Tang, Shujing Zhang, Hang Wang, Fengjie Zheng   +9 more
doaj   +1 more source

Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]

, 2013
The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
core   +2 more sources

Ni2+-Assisted Hydrolysis May Affect the Human Proteome; Filaggrin Degradation Ex Vivo as an Example of Possible Consequences

Frontiers in Molecular Biosciences, 2022
Deficiency in a principal epidermal barrier protein, filaggrin (FLG), is associated with multiple allergic manifestations, including atopic dermatitis and contact allergy to nickel.
Ewa Izabela Podobas, Ewa Izabela Podobas, Ewa Izabela Podobas, Danuta Gutowska-Owsiak, Danuta Gutowska-Owsiak, Sébastien Moretti, Jarosław Poznański, Mariusz Kulińczak, Marcin Grynberg, Aleksandra Gruca, Arkadiusz Bonna, Dawid Płonka, Tomasz Frączyk, Graham Ogg, Wojciech Bal   +14 more
doaj   +1 more source

Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21^WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]

, 2008
To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L., Chan, W-C., Greenhalgh, D.A., Quinn, J., Wu, H., Yao, D.   +5 more
core   +1 more source

Physicochemical study of a synthetic peptide belonging to human filaggrin protein [PDF]

Le Journal de Physique IV, 2001
In the present work the physicochemical characterization of the (306-324) synthetic peptide sequence from human fiiaggrin protein and its palmitoilated derivative was carried out. Monomolecular layers of dipalmitoilphosphatidilcholine (DPPC) were used to study lipidtpeptide interactions.
T. Pérez, M. Muñoz, Y. Jaouher, M. A. Alsina, I. Haro   +4 more
openaire   +1 more source

A possible association between a dysfunctional skin barrier (filaggrin null-mutation status) and diabetes: a cross-sectional study

BMJ Open, 2011
Background Filaggrin proteins are located in the skin and prevent epidermal water loss and impede the entry of micro-organisms, allergens and chemicals.
Allan Linneberg, Torben Hansen, Jacob P Thyssen, Steen Stender, Oluf Pedersen, Berit C Carlsen, Jeanne D Johansen, Kåre Engkilde, Flemming Pociot, Michael Meldgaard, Pal B Szecsi, Torkil Menné   +11 more
doaj   +1 more source

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. [PDF]

, 2015
Keratin intermediate filaments (KIFs) protect the epidermis against mechanical force, support strong adhesion, help barrier formation, and regulate growth.
Adams, Alam, Alvarado, Arin, Baris, Bianchi, Bligh, Bunick, Bär, Böttinger, Candi, Candi, Capetanaki, Chan, Chernoivanenko, Christina B. Brazel, Chung, Coulombe, Coulombe, Crowe, Dennis R. Roop, Duan, Egberts, Ellis, Epand, Fessing, Fontanesi, Fuchs, Fuchs, Gendronneau, Geng, Habtezion, Haines, Hamanaka, Hans Binder, Hardman, Helenius, Henry Löffler-Wirth, Herrmann, Hesse, Hoefs, Homberg, Homberg, Hornig-Do, Hoste, Hue-Tran Hornig-Do, Huebner, Jamal-Eddine Bouameur, Janina Bär, Jaquemar, Jarnik, Jayaprakash, Kalinin, Kato, Kawasaki, Kerns, Kim, Kim, Kloepper, Koch, Kröger, Kröger, Kuramoto, Kypriotou, Laatsch, Lane, Langbein, Lessard, Lim, Loschke, Macdiarmid, Magin, Matsui, Matsuki, McAleer, Mor-Vaknin, Nakamichi, Nestle, Nicole Schwarz, Nishizawa, Norlén, Oji, Owens, Palmer, Panjwani, Paradies, Peter Seibel, Preethi Vijayaraj, Quigley, Reichelt, Reichelt, Reichelt, Rice, Rice, Rice, Robert H. Rice, Roop, Rorke, Roth, Roth, Rowland, Rudolf E. Leube, Rudolf J. Wiesner, Sabharwal, Sakaguchi, Samuelov, Samuelov, Sandilands, Sandra Heller, Schmuth, Schweizer, Schäfer, Schäfer, Segre, Segre, Seltmann, Seltmann, Seltmann, Sevilla, Signorelli, Simpson, Singla, Smith, Susanne Brodesser, Szeverenyi, Sören Thiering, Takahashi, Tamai, Tao, Tasseva, Tatsuta, Thomas M. Magin, Vijayaraj, Vijayaraj, Vinod Kumar, Wallace, Watt, Yao, Yu, Zeeuwen, Özbalci   +140 more
core   +1 more source

Proteomic Analysis of Urine to Identify Breast Cancer Biomarker Candidates Using a Label-Free LC-MS/MS Approach. [PDF]

PLoS ONE, 2015
Breast cancer is a complex heterogeneous disease and is a leading cause of death in women. Early diagnosis and monitoring progression of breast cancer are important for improving prognosis.
Julia Beretov, Valerie C Wasinger, Ewan K A Millar, Peter Schwartz, Peter H Graham, Yong Li   +5 more
doaj   +1 more source

Differences in Behavior between Normal and Atopic Keratinocytes in Culture: Pilot Studies

Veterinary Sciences, 2022
Skin barrier dysfunction is important in atopic dermatitis and can be secondary to inflammation. Observation of keratinocytes in culture may show intrinsic differences. TransEpithelial Electrical Resistance (TEER) measures epithelial permeability.
Rosanna Marsella, Kim Ahrens, Rachel Wilkes   +2 more
doaj   +1 more source